Search Results - "Colunga, Maria Ledesma"

Transferrin receptor 2 mitigates periodontitis‐driven alveolar bone loss by Lösser, Lennart, Ledesma‐Colunga, Maria G., Sastre, Enrique Andrés, Scholtysek, Carina, Hofbauer, Lorenz C., Noack, Barbara, Baschant, Ulrike, Rauner, Martina

“…Periodontitis is associated with significant alveolar bone loss. Patients with iron overload suffer more frequently from periodontitis, however, the underlying…”
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Prolactin Inhibits or Stimulates the Inflammatory Response of Joint Tissues in a Cytokine-dependent Manner by García-Rodrigo, Jose Fernando, Ortiz, Georgina, Martínez-Díaz, Oscar Fernando, Furuzawa-Carballeda, Janette, Ruíz-Herrera, Xarubet, Macias, Fernando, Ledesma-Colunga, María G, Martínez de la Escalera, Gonzalo, Clapp, Carmen

“…Abstract The close association between rheumatoid arthritis (RA), sex, reproductive state, and stress has long linked prolactin (PRL) to disease progression…”
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Vasoinhibin is Generated and Promotes Inflammation in Mild Antigen-induced Arthritis by Ortiz, Georgina, Ledesma-Colunga, Maria G, Wu, Zhijian, García-Rodrigo, Jose F, Adan, Norma, Martinez-Diaz, Oscar F, De Los Ríos, Ericka A, López-Barrera, Fernando, Martínez de la Escalera, Gonzalo, Clapp, Carmen

“…Inflammatory arthritis defines a family of diseases influenced by reproductive hormones. Vasoinhibin, a fragment of the hormone prolactin (PRL), has…”
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Dual Roles of Prolactin and Vasoinhibin in Inflammatory Arthritis by Clapp, Carmen, Ortiz, Georgina, García-Rodrigo, Jose F., Ledesma-Colunga, María G., Martínez-Díaz, Oscar F., Adán, Norma, Martínez de la Escalera, Gonzalo

“…The term inflammatory arthritis defines a family of diseases, including rheumatoid arthritis (RA), caused by an overactive immune system, and influenced by…”
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Comparison of the effects of high dietary iron levels on bone microarchitecture responses in the mouse strains 129/Sv and C57BL/6J by Ledesma-Colunga, Maria G., Passin, Vanessa, Vujic Spasic, Maja, Hofbauer, Lorenz C., Baschant, Ulrike, Rauner, Martina

“…Iron is an essential nutrient for all living organisms. Both iron deficiency and excess can be harmful. Bone, a highly metabolic active organ, is particularly…”
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Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis by Ledesma-Colunga, Maria G, Adán, Norma, Ortiz, Georgina, Solís-Gutiérrez, Mariana, López-Barrera, Fernando, Martínez de la Escalera, Gonzalo, Clapp, Carmen

“…Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we…”
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Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis by Ledesma-Colunga, Maria G., Baschant, Ulrike, Weidner, Heike, Alves, Tiago C., Mirtschink, Peter, Hofbauer, Lorenz C., Rauner, Martina

“…Rheumatoid arthritis is an inflammatory joint disease in which synovial iron deposition has been described. Transferrin receptor 2 (Tfr2) represents a critical…”
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Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes by Weidner, Heike, Baschant, Ulrike, Lademann, Franziska, Ledesma Colunga, Maria G, Balaian, Ekaterina, Hofbauer, Christine, Misof, Barbara M, Roschger, Paul, Blouin, Stéphane, Richards, William G, Platzbecker, Uwe, Hofbauer, Lorenz C, Rauner, Martina

“…Myelodysplastic syndromes (MDS) are clonal malignant hematopoietic disorders in the elderly characterized by ineffective hematopoiesis. This is accompanied by…”
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Depletion of macrophages and osteoclast precursors mitigates iron overload‐mediated bone loss by Passin, Vanessa, Ledesma‐Colunga, Maria G., Altamura, Sandro, Muckenthaler, Martina U., Baschant, Ulrike, Hofbauer, Lorenz C., Rauner, Martina

“…Iron is an essential element for physiological cellular processes, but is toxic in excess. Iron overload diseases are commonly associated with low bone mass…”
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Shaping the bone through iron and iron-related proteins by Ledesma-Colunga, Maria G., Weidner, Heike, Vujic Spasic, Maja, Hofbauer, Lorenz C., Baschant, Ulrike, Rauner, Martina

“…Well-controlled iron levels are indispensable for health. Iron deficiency is the most common cause of anemia, whereas iron overload, either hereditary or…”
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Bone marrow transplantation reduces FGF-23 levels and restores bone formation in myelodysplastic neoplasms by Weidner, Heike, Baschant, Ulrike, Ledesma-Colunga, Maria G., Basiak, Karolina, Tsourdi, Elena, Sockel, Katja, Götze, Katharina S., Rivière, Jennifer, Platzbecker, Uwe, Hofbauer, Lorenz C., Rauner, Martina

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Novel Insights into Osteoclast Energy Metabolism by Ledesma-Colunga, Maria G., Passin, Vanessa, Lademann, Franziska, Hofbauer, Lorenz C., Rauner, Martina

“…Purpose of Review Osteoclasts are crucial for the dynamic remodeling of bone as they resorb old and damaged bone, making space for new bone. Metabolic…”
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Disruption of the hepcidin/ferroportin regulatory circuitry causes low axial bone mass in mice by Ledesma-Colunga, Maria G., Baschant, Ulrike, Fiedler, Imke A.K., Busse, Björn, Hofbauer, Lorenz C., Muckenthaler, Martina U., Altamura, Sandro, Rauner, Martina

“…Ferroportin (FPN) is the only known iron exporter. Mutations conferring resistance of FPN to hepcidin-mediated degradation cause the iron overload disorder…”
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Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis by Ortiz, Georgina, Ledesma-Colunga, Maria G., Wu, Zhijian, García-Rodrigo, Jose F., Adan, Norma, Martínez de la Escalera, Gonzalo, Clapp, Carmen

“…Increased permeability and growth (angiogenesis) of blood vessels play a key role in joint swelling and pannus formation in inflammatory arthritis, a family of…”
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Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis by Adán, Norma, Guzmán-Morales, Jessica, Ledesma-Colunga, Maria G, Perales-Canales, Sonia I, Quintanar-Stéphano, Andrés, López-Barrera, Fernando, Méndez, Isabel, Moreno-Carranza, Bibiana, Triebel, Jakob, Binart, Nadine, Martínez de la Escalera, Gonzalo, Thebault, Stéphanie, Clapp, Carmen

“…Chondrocytes are the only cells in cartilage, and their death by apoptosis contributes to cartilage loss in inflammatory joint diseases, such as rheumatoid…”
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The role of the prolactin/vasoinhibin axis in rheumatoid arthritis: an integrative overview by Clapp, Carmen, Adán, Norma, Ledesma-Colunga, María G., Solís-Gutiérrez, Mariana, Triebel, Jakob, Martínez de la Escalera, Gonzalo

“…Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease destroying articular cartilage and bone. The female preponderance and the influence of…”
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Prolactin regulates liver growth during postnatal development in mice by Moreno-Carranza, Bibiana, Bravo-Manríquez, Marco, Baez, Arelí, Ledesma-Colunga, Maria G, Ruiz-Herrera, Xarubet, Reyes-Ortega, Pamela, de Los Ríos, Ericka A, Macotela, Yazmín, Martínez de la Escalera, Gonzalo, Clapp, Carmen

“…The liver grows during the early postnatal period first at slower and then at faster rates than the body to achieve the adult liver-to-body weight ratio (LBW),…”
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Diabetes enhances the efficacy of AAV2 vectors in the retina: therapeutic effect of AAV2 encoding vasoinhibin and soluble VEGF receptor 1 by Díaz-Lezama, Nundehui, Wu, Zhijian, Adán-Castro, Elva, Arnold, Edith, Vázquez-Membrillo, Miguel, Arredondo-Zamarripa, David, Ledesma-Colunga, Maria G, Moreno-Carranza, Bibiana, Martinez de la Escalera, Gonzalo, Colosi, Peter, Clapp, Carmen

“…Adeno-associated virus (AAV) vector-mediated delivery of inhibitors of blood–retinal barrier breakdown (BRBB) offers promise for the treatment of diabetic…”
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Prolactin-derived vasoinhibins increase anxiety- and depression-related behaviors by Zamorano, Miriam, Ledesma-Colunga, Maria G, Adán, Norma, Vera-Massieu, Camila, Lemini, Maria, Méndez, Isabel, Moreno-Carranza, Bibiana, Neumann, Inga D, Thebault, Stéphanie, Martínez de la Escalera, Gonzalo, Torner, Luz, Clapp, Carmen

“…Summary The hormone prolactin (PRL) regulates neuroendocrine and emotional stress responses. It is found in the hypothalamus, where the protein is partially…”
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Dickkopf1 fuels inflammatory cytokine responses by Jaschke, Nikolai P., Pählig, Sophie, Sinha, Anupam, Adolph, Timon E., Colunga, Maria Ledesma, Hofmann, Maura, Wang, Andrew, Thiele, Sylvia, Schwärzler, Julian, Kleymann, Alexander, Gentzel, Marc, Tilg, Herbert, Wielockx, Ben, Hofbauer, Lorenz C., Rauner, Martina, Göbel, Andy, Rachner, Tilman D.

“…Many human diseases, including cancer, share an inflammatory component but the molecular underpinnings remain incompletely understood. We report that…”
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