Search Results - "Colucci, Marie A."

Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target by Yan, Chao, Shieh, Biehuoy, Reigan, Philip, Zhang, Zhiyong, Colucci, Marie A, Chilloux, Aurélie, Newsome, Jeffery J, Siegel, David, Chan, Dan, Moody, Christopher J, Ross, David

“…The indolequinone ES936 {5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione} was previously developed in our lab as an antitumor agent against…”
Get more information

Synthesis and Evaluation of 3-Aryloxymethyl-1,2-dimethylindole-4,7-diones as Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Activity by Colucci, Marie A, Reigan, Philip, Siegel, David, Chilloux, Aurélie, Ross, David, Moody, Christopher J

“…NAD(P)H:quinone oxidoreductase 1 is a proposed target in pancreatic cancer. We describe the synthesis of a series of indolequinones, based on the 5- and…”
Get full text

Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition by Dufour, Marine, Yan, Chao, Siegel, David, Colucci, Marie A., Jenner, Matthew, Oldham, Neil J., Gomez, Joe, Reigan, Philip, Li, Yazhuo, De Matteis, Cristina I., Ross, David, Moody, Christopher J.

“…A role for the flavoprotein NRH:quinone oxidoreductase 2 (NQO2, QR2) in human diseases such as malaria, leukemia and neurodegeneration has been proposed. In…”
Get full text

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential by Colucci, Marie A, Moody, Christopher J, Couch, Gavin D

“…The quinone reductase enzyme NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the two-electron reduction of quinones. This…”
Get more information

Development of Indolequinone Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1):  NQO1 Inhibition and Growth Inhibitory Activity in Human Pancreatic MIA PaCa-2 Cancer Cells by Reigan, Philip, Colucci, Marie A, Siegel, David, Chilloux, Aurélie, Moody, Christopher J, Ross, David

“…NAD(P)H:quinone oxidoreductase 1 (NQO1) is currently an emerging target in pancreatic cancer. In this report, we describe a series of indolequinones, based on…”
Get full text

Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles by Maskell, Lesley, Blanche, Emilie A., Colucci, Marie A., Whatmore, Jacqueline L., Moody, Christopher J.

“…Potential prodrugs of inhibitors of VEGF-induced angiogenesis have been investigated. The prodrug systems studied were the 4-nitrobenzyl, 2-nitrophenylacetyl…”
Get full text

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1 by Newsome, Jeffery J, Colucci, Marie A, Hassani, Mary, Beall, Howard D, Moody, Christopher J

“…A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant…”
Get more information

Synthesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles by Blanche, Emilie A., Maskell, Lesley, Colucci, Marie A., Whatmore, Jacqueline L., Moody, Christopher J.

“…A number of potential prodrug systems for reductive activation have been investigated. The prodrug systems chosen for the study were the 2-nitrophenylacetyl,…”
Get full text

New functionalised silicas for highly selective cation exchange SPE purification in medicinal chemistry by Brown, Jane, Chighine, Alessandra, Colucci, Marie A., Galaffu, Nicola, Hirst, Simon C., Seymour, Helen M., Shiers, Jason J., Wilkes, Robin D., Williams, Jonathan G., Wilson, John R.H.

“…Functionalised silicas 2 and 3 are effective for cation exchange purifications of basic molecules containing acid-sensitive functionalities, selective…”
Get full text

The use of hexamethyldisilathiane for the synthesis of transition metal sulfides by Carmalt, Claire J., Dinnage, Christopher W., Parkin, Ivan P., Peters, Emily S., Molloy, Kieran, Colucci, Marie A.

“…The reaction of TiCl 4 with hexamethyldisilathiane in diethyl ether at room temperature affords black precipitates which upon annealing under H 2S at 800 °C…”
Get full text