Search Results - "Colton, C D"

Chemical Synthesis and Enzymatic Activity of a 99-Residue Peptide with a Sequence Proposed for the Human Immunodeficiency Virus Protease by Nutt, Ruth F., Brady, Stephen F., Darke, Paul L., Ciccarone, Terrence M., Colton, C. Dylion, Nutt, Elka M., Rodkey, John A., Bennett, Carl D., Waxman, Lloyd H., Sigal, Irving S., Anderson, Paul S., Veber, Daniel F.

“…Retroviral proteins, including those from the human immunodeficiency virus (HIV), are synthesized as polyprotein precursors that require proteolytic cleavage…”
Get full text

Identification of high affinity endothelin-1 receptor subtypes in human tissues by Williams, Jr, D L, Jones, K L, Colton, C D, Nutt, R F

“…Two subtypes of the high affinity endothelin-1 (ET-1) receptor were identified in human tissue, and were distinguished by their differential affinities for…”
Get more information

NMR and molecular modeling characterization of RGD containing peptides by Bogusky, M J, Naylor, A M, Pitzenberger, S M, Nutt, R F, Brady, S F, Colton, C D, Sisko, J T, Anderson, P S, Veber, D F

“…The tripeptide sequence arginine-glycine-aspartic acid (RGD) has been shown to be the key recognition segment in numerous cell adhesion proteins. The solution…”
Get more information

Conformationally constrained tachykinin analogs which are selective ligands for the eledoisin binding site by Cascieri, M A, Chicchi, G G, Freidinger, R M, Colton, C D, Perlow, D S, Williams, B, Curtis, N R, McKnight, A T, Maguire, J J, Veber, D F

“…We have prepared a series of conformationally constrained hexapeptide analogs of substance P which are 500-1500-fold more potent as inhibitors of 125I-labeled…”
Get more information

Clearance and early hydrolysis of atrial natriuretic factor in vivo: structural analysis of cleavage sites and design of an analogue that inhibits hormone cleavage by CONDRA, C. L, LEIDY, E. A, BUNTING, P, COLTON, C. D, NUTT, R. F, ROSENBLATT, M, JACOBS, J. W

“…This study examines the clearance and early hydrolysis of atrial natriuretic factor (ANF) in vivo. Radiolabeled ANF was cleared from the circulation of the rat…”
Get full text

A super active cyclic hexapeptide analog of somatostatin by Veber, D F, Saperstein, R, Nutt, R F, Freidinger, R M, Brady, S F, Curley, P, Perlow, D S, Paleveda, W J, Colton, C D, Zacchei, A G

“…The cyclic hexapeptide, cyclo (Pro-Phe-D-Trp-Lys-Thr-Phe), I, has been shown to have the biological properties of somatostatin. We now report…”
Get more information

The solution conformation of Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist by Bogusky, M J, Naylor, A M, Mertzman, M E, Pitzenberger, S M, Nutt, R F, Brady, S F, Colton, C D, Veber, D F

“…The solution conformation of Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist, was characterized in DMSO-d6 by the combination of nmr and…”
Get more information

A useful synthesis of 3-oxodihydroisoindoles by Anderson, P. S, Christy, M. E, Colton, C. D, Shepard, K. L

Get full text

Amino Acid Sequence of Homologous Rat Atrial Peptides: Natriuretic Activity of Native and Synthetic Forms by Seidah, N. G., Lazure, C., Chrétien, M., Thibault, G., Garcia, R., Cantin, M., Genest, J., Nutt, R. F., Brady, S. F., Lyle, T. A., Paleveda, W. J., Colton, C. D., Ciccarone, T. M., Veber, D. F.

“…A substance called atrial natriuretic factor (ANF), localized in secretory granules of atrial cardiocytes, was isolated as four homologous natriuretic peptides…”
Get full text

Amide and α-keto carbonyl inhibitors of thrombin based on arginine and lysine: Synthesis, stability and biological characterization by Brady, Stephen F., Sisko, John T., Stauffer, Kenneth J., Colton, Christiana D., Qiu, Howard, Lewis, Sidney D., Ng, Assunta S., Shafer, Jules A., Bogusky, Michael J., Veber, Daniel F., Nutt, Ruth F.

“…We report structure-activity investigations in a series of tripeptide amide inhibitors of thrombin, and the development of a series of highly potent active…”
Get full text

Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists by Thompson, Wayne J, Anderson, Paul S, Britcher, Susan F, Lyle, Terry A, Thies, J. Eric, Magill, Catherine A, Varga, Sandor L, Schwering, John E, Lyle, Paulette A

“…A series of 73 dibenzo[a,d]cycloalkenimines were synthesized and evaluated for their ability to displace…”
Get full text

Somatostatin analogs with improved oral bioavailability by Nutt, R F, Colton, C D, Veber, D F, Slater, E L, Saperstein, R

“…Cyclic hexapeptide analogs of somatostatin with insulin, glucagon, and growth hormone (GH) release inhibitory potencies of 50-200 times those of somatostatin…”
Get more information

Large-scale synthesis of a cyclic hexapeptide analog of somatostatin by Brady, Stephen F, Freidinger, Roger M, Paleveda, William J, Colton, Christiane D, Homnick, Carl F, Whitter, Willie L, Curley, Paul, Nutt, Ruth F, Veber, Daniel F

Get full text

Chemical synthesis of rat atrial natriuretic factor by fragment assembly on a solid support by Lyle, Terry A, Brady, Stephen F, Ciccarone, Terry M, Colton, Christiane D, Paleveda, William J, Veber, Daniel F, Nutt, Ruth F

Get full text

Synthesis of new peptides based on models of receptor-bound conformation by Freidinger, R M, Brady, S F, Paleveda, W J, Perlow, D S, Colton, C D, Whitter, W L, Saperstein, R, Brady, E J, Cascieri, M A, Veber, D F

Get more information

Hyperactivity versus explosive motor behavior induced by opioids in the rat. Mechanisms elucidated with enkephalin-tyrosine-o-sulfate and morphine congeners by LaBella, F S, Pinsky, C, Christy, M E, Colton, C D

“…A relatively mild hyperactive state (HAS), characterized by agitation and hypermotility, is induced by opiate drugs and opioid peptides in general and is…”
Get more information

Structure-Activity Relationships in the Cyproheptadine Series by Engelhardt, Edward L, Zell, Howard C, Saari, Walfred S, Christy, Marcia E, Colton, C. Dylion, Stone, Clement A, Stavorski, John M, Wenger, Herbert C, Ludden, Carl T

Get full text

Antidepressants. Tetrabenazine-antagonizing activity in a series of 5H-dibenzo[cycloheptene-5-propylamines by Engelhardt, Edward L, Christy, Marcia E, Colton, C. Dylion, Freedman, Mark B, Boland, Carole C, Halpern, Lawrence M, Vernier, Vernon G, Stone, Clement Addison

Get full text

Chemical synthesis and enzymatic activity of a 99-residue peptide with a sequence proposed for the human immunodeficiency virus protease by Nutt, R F, Brady, S F, Darke, P L, Ciccarone, T M, Colton, C D, Nutt, E M, Rodkey, J A, Bennett, C D, Waxman, L H, Sigal, I S

“…Retroviral proteins, including those from the human immunodeficiency virus (HIV), are synthesized as polyprotein precursors that require proteolytic cleavage…”
Get full text

2-, 3-, and 4-(.alpha.,.alpha.,.beta.,.beta.-Tetrafluorophenethyl)benzylamines. A new class of antiarrhythmic agents by Christy, Marcia E, Colton, C. Dylion, Mackay, Mary, Staas, William H, Wong, Julia B, Engelhardt, Edward L, Torchiana, Mary L, Stone, Clement A

Get full text