Search Results - "Colquhoun, Jennifer"

Insights Into Mechanisms of Biofilm Formation in Acinetobacter baumannii and Implications for Uropathogenesis by Colquhoun, Jennifer M, Rather, Philip N

“…Multidrug resistant is a serious healthcare threat. In fact, the Center for Disease Control recently reported that carbapenem-resistant is responsible for more…”
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Transcription and translation of the sigG gene is tuned for proper execution of the switch from early to late gene expression in the developing Bacillus subtilis spore by Mearls, Elizabeth B, Jackter, Jacquelin, Colquhoun, Jennifer M, Farmer, Veronica, Matthews, Allison J, Murphy, Laura S, Fenton, Colleen, Camp, Amy H

“…A cascade of alternative sigma factors directs developmental gene expression during spore formation by the bacterium Bacillus subtilis. As the spore develops,…”
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OXA-23 β-Lactamase Overexpression in Acinetobacter baumannii Drives Physiological Changes Resulting in New Genetic Vulnerabilities by Colquhoun, Jennifer M, Farokhyfar, Marjan, Hutcheson, Anna R, Anderson, Alexander, Bethel, Christopher R, Bonomo, Robert A, Clarke, Anthony J, Rather, Philip N

“…β-Lactamase expression is the major mechanism of resistance to penicillins, cephalosporins, and carbapenems in the multidrug-resistant (MDR) bacterium…”
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Evidence for Rho-dependent control of a virulence switch in Acinetobacter baumannii by Pérez-Varela, María, Singh, Raja, Colquhoun, Jennifer M, Starich, Olivia G, Tierney, Aimee R P, Tipton, Kyle A, Rather, Philip N

“…is a significant cause of infections in the healthcare setting. More recently, has been a leading cause of secondary bacterial pneumonia in patients infected…”
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Collateral Changes in Cell Physiology Associated with ADC-7 β-Lactamase Expression in Acinetobacter baumannii by Colquhoun, Jennifer M, Farokhyfar, Marjan, Anderson, Alexander C, Bethel, Christopher R, Bonomo, Robert A, Clarke, Anthony J, Rather, Philip N

“…The ADC (AmpC) β-lactamase is universally present in the Acinetobacter baumannii chromosome, suggesting it may have a yet-to-be-identified cellular function…”
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Cohesinopathies of a feather flock together by Skibbens, Robert V, Colquhoun, Jennifer M, Green, Megan J, Molnar, Cody A, Sin, Danielle N, Sullivan, Brian J, Tanzosh, Eden E

“…Roberts Syndrome (RBS) and Cornelia de Lange Syndrome (CdLS) are severe developmental maladies that present with nearly an identical suite of multi-spectrum…”
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Clinically Relevant Growth Conditions Alter Acinetobacter baumannii Antibiotic Susceptibility and Promote Identification of Novel Antibacterial Agents by Colquhoun, Jennifer M, Wozniak, Rachel A F, Dunman, Paul M

“…Biological processes that govern bacterial proliferation and survival in the host-environment(s) are likely to be vastly different from those that are required…”
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Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus by Perlmutter, Jessamyn I, Forbes, Lauren T, Krysan, Damian J, Ebsworth-Mojica, Katherine, Colquhoun, Jennifer M, Wang, Jenna L, Dunman, Paul M, Flaherty, Daniel P

“…Staphylococcus aureus is a rapidly growing health threat in the U.S., with resistance to several commonly prescribed treatments. A high-throughput screen…”
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Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus by Budnick, James A, Sheehan, Lauren M, Colquhoun, Jennifer M, Dunman, Paul M, Walker, Graham C, Roop, 2nd, R Martin, Caswell, Clayton C

“…The YbeY endoribonuclease is one of the best-conserved proteins across the kingdoms of life. In the present study, we demonstrated that YbeY in is linked to a…”
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Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii by Introvigne, Maria Luisa, Beardsley, Trevor J, Fernando, Micah C, Leonard, David A, Wallar, Bradley J, Rudin, Susan D, Taracila, Magdalena A, Rather, Philip N, Colquhoun, Jennifer M, Song, Shaina, Fini, Francesco, Hujer, Kristine M, Hujer, Andrea M, Prati, Fabio, Powers, Rachel A, Bonomo, Robert A, Caselli, Emilia

“…is a Gram-negative organism listed as an urgent threat pathogen by the World Health Organization (WHO). Carbapenem-resistant (CRAB), especially, present…”
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Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA by Colquhoun, Jennifer M, Ha, Lisha, Beckley, Andrew, Meyers, Brinkley, Flaherty, Daniel P, Dunman, Paul M

“…RnpA is thought to be a unique dual functional antimicrobial target that is required for two essential cellular processes, precursor tRNA processing and…”
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Functional interplay between ribosomal protein paralogues in the eRpL22 family in Drosophila melanogaster by Mageeney, Catherine M., Kearse, Michael G., Gershman, Brett W., Pritchard, Caroline E., Colquhoun, Jennifer M., Ware, Vassie C.

“…Duplicated ribosomal protein (RP) genes in the Drosophila melanogaster eRpL22 family encode structurally-divergent and differentially-expressed rRNA-binding…”
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Complete Genome of Bacillus subtilis Myophage CampHawk by Ritz, Morgan P, Perl, Abbey L, Colquhoun, Jennifer M, Chamakura, Karthik R, Kuty Everett, Gabriel F

“…The study of bacteriophages infecting the model organism Bacillus subtilis has provided an abundance of general knowledge and a platform for advances in…”
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Complete Genome of Bacillus subtilis Myophage Grass by Miller, Stanton Y, Colquhoun, Jennifer M, Perl, Abbey L, Chamakura, Karthik R, Kuty Everett, Gabriel F

“…Bacillus subtilis is a ubiquitous Gram-positive model organism. Here, we describe the complete genome of B. subtilus myophage Grass. Aside from genes encoding…”
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Intestinal organoids for modelling intestinal development and disease by Fair, Kathryn L., Colquhoun, Jennifer, Hannan, Nicholas R. F.

“…Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited…”
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Intestinal organoids for modelling intestinal development and disease by Fair, Kathryn L., Colquhoun, Jennifer, Hannan, Nicholas R. F.

“…Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited…”
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Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments by Blanchard, Catlyn, Brooks, Lauren, Beckley, Andrew, Colquhoun, Jennifer, Dewhurst, Stephen, Dunman, Paul M

“…In the midst of the current antimicrobial pipeline void, alternative approaches are needed to reduce the incidence of infection and decrease reliance on…”
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Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin by Lounsbury, Nicole, Eidem, Tess, Colquhoun, Jennifer, Mateo, George, Abou-Gharbia, Magid, Dunman, Paul M., Childers, Wayne E.

“…We recently discovered RnpA as a promising new drug discovery target for methicillin-resistant S. aureus (MRSA). RnpA is an essential protein that is thought…”
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Crystal structure of the ribonuclease‐P‐protein subunit from Staphylococcus aureus by Ha, Lisha, Colquhoun, Jennifer, Noinaj, Nicholas, Das, Chittaranjan, Dunman, Paul M., Flaherty, Daniel P.

“…Staphylococcus aureus ribonuclease‐P‐protein subunit (RnpA) is a promising antimicrobial target that is a key protein component for two essential cellular…”
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Characterization of Staphylococccus aureus RnpA and Approaches for Antibacterial Discovery by Colquhoun, Jennifer Marie

“…Staphylococcus aureus is a predominant cause of nosocomial and community acquired bacterial infections and has developed resistance to front-line antibiotics…”
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