Search Results - "Colosimo, Dominic A."

Accessing Bioactive Natural Products from the Human Microbiome by Milshteyn, Aleksandr, Colosimo, Dominic A., Brady, Sean F.

“…Natural products have long played a pivotal role in the development of therapeutics for a variety of diseases. Traditionally, soil and marine environments have…”
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Nonenzymatic Reactions in Natural Product Formation by Bouthillette, Leah M., Aniebok, Victor, Colosimo, Dominic A., Brumley, David, MacMillan, John B.

“…Biosynthetic mechanisms of natural products primarily depend on systems of protein catalysts. However, within the field of biosynthesis, there are cases in…”
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Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors by Colosimo, Dominic A., Kohn, Jeffrey A., Luo, Peter M., Piscotta, Frank J., Han, Sun M., Pickard, Amanda J., Rao, Arka, Cross, Justin R., Cohen, Louis J., Brady, Sean F.

“…Despite evidence linking the human microbiome to health and disease, how the microbiota affects human physiology remains largely unknown. Microbiota-encoded…”
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Synthetic-Bioinformatic Natural Product Antibiotics with Diverse Modes of Action by Chu, John, Koirala, Bimal, Forelli, Nicholas, Vila-Farres, Xavier, Ternei, Melinda A, Ali, Thahmina, Colosimo, Dominic A, Brady, Sean F

“…Bacterial natural products have inspired the development of numerous antibiotics in use today. As resistance to existing antibiotics has become more prevalent,…”
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Detailed Mechanistic Study of the Non-enzymatic Formation of the Discoipyrrole Family of Natural Products by Colosimo, Dominic A, MacMillan, John B

“…Discoipyrroles A–D (DPA–DPD) are recently discovered natural products produced by the marine bacterium Bacillus hunanensis that exhibit anticancer properties…”
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Generation of Highly Cytotoxic Natural Killer Cells for Treatment of Acute Myelogenous Leukemia Using a Feeder-Free, Particle-Based Approach by Oyer, Jeremiah L, Igarashi, Robert Y, Kulikowski, Alexander R, Colosimo, Dominic A, Solh, Melhem M, Zakari, Ahmed, Khaled, Yasser A, Altomare, Deborah A, Copik, Alicja J

“…Abstract Natural killer (NK) cell immunotherapy as a cancer treatment shows promise, but expanding NK cells consistently from a small fraction (∼5%) of…”
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In Vivo Expansion of NK Cells Stimulated with PM21 Particles Under Ultralow IL-2 by Oyer, Jeremiah L, Pandey, Veethika, Colosimo, Dominic A, Igarashi, Robert Y., PhD, Zakari, Ahmed, MD, Solh, Melhem, MD, Altomare, Deborah A., PhD, Copik, Alicja J., PhD

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In Vitro Preactivation of PBMCs with PM-mb21-41BBL Particles Stimulates in Vivo Expansion of NK Cells Under Low IL-2 in NSG Mice by Oyer, Jeremiah L, Pandey, Veethika, Igarashi, Robert Y, Colosimo, Dominic A, Solh, Melhem M., Altomare, Deborah A, Copik, Alicja J

“…NK cell immunotherapy as a cancer treatment shows promise, but methods for consistent expansion of NK cells from a small fraction (~5%) of peripheral blood…”
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