Search Results - "Colon, SM"

Influence of hurricane winds on Caribbean dry forest structure and nutrient pools by Van Bloem, S.J, Murphy, P.G, Lugo, A.E, Ostertag, R, Rivera Costa, M, Ruiz Bernard, I, Molina Colon, S, Canals Mora, S

“…In 1998, we measured the effects of Hurricane Georges after it passed over long-term research sites in Puerto Rican dry forest. Our primary objectives were to…”
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Therapeutic levels of factor IX expression using a muscle-specific promoter and adeno-associated virus serotype 1 vector by Liu, Yi-Lin, Mingozzi, Federico, Rodriguéz-Colôn, Sol M, Joseph, Sasha, Dobrzynski, Eric, Suzuki, Takashi, High, Katherine A, Herzog, Roland W

“…Extensive studies in animal models of the X-linked bleeding disorder hemophilia B (deficiency in functional coagulation factor IX, F.IX) have shown that…”
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On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs by O'Sullivan, D, Arrhenius, T, Sidney, J, Del Guercio, MF, Albertson, M, Wall, M, Oseroff, C, Southwood, S, Colon, SM, Gaeta, FC

“…We have investigated the interaction between DR1 molecules and the two antigenic peptides, tetanus toxoid 830-843 and hemagglutinin 307-319, previously known…”
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The Relation between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides by Buus, Soren, Sette, Alessandro, Colon, Sonia M., Miles, Craig, Grey, Howard M.

“…The capacity of purified I-A$^{\text{d}}$, I-E$^{\text{d}}$, I-A$^{\text{k}}$, and I-E$^{\text{k}}$ to bind to protein derived peptides that have been…”
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Isolation and characterization of antigen-Ia complexes involved in T cell recognition by Buus, S, Sette, A, Colon, S M, Jenis, D M, Grey, H M

“…Using equilibrium dialysis, it has been previously demonstrated that immunogenic peptides bind specifically to the Ia molecules serving as restriction elements…”
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HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions by Sette, A, Sidney, J, Oseroff, C, del Guercio, MF, Southwood, S, Arrhenius, T, Powell, MF, Colon, SM, Gaeta, FC, Grey, HM

“…In the present study, we describe the definition of a DRB1*0401 (DR4w4)-specific motif. The strategy used entailed a three-step process: 1) screening a large…”
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Recovery of a Subtropical Dry Forest After Abandonment of Different Land Uses by Colón, Sandra Molina, Lugo, Ariel E

“…We studied the ecological characteristics of 45-50-yr-old subtropical dry forest stands in Puerto Rico that were growing on sites that had been deforested and…”
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Prediction of Major Histocompatibility Complex Binding Regions of Protein Antigens by Sequence Pattern Analysis by Sette, Alessandro, Buus, Soren, Appella, Ettore, Smith, John A., Chesnut, Robert, Miles, Craig, Colon, Sonia M., Grey, Howard M.

“…We have previously experimentally analyzed the structural requirements for interaction between peptide antigens and mouse major histocompatibility complex…”
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Functional consequences of engagement of the T cell receptor by low affinity ligands by Alexander, J, Snoke, K, Ruppert, J, Sidney, J, Wall, M, Southwood, S, Oseroff, C, Arrhenius, T, Gaeta, FC, Colon, SM

“…The mechanisms involved in TCR antagonism by Ag analog/MHC have been analyzed. A detailed structure-activity relationship study indicated that modification of…”
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Characterization of the specificity of peptide binding to four DR haplotypes by O'Sullivan, D, Sidney, J, Appella, E, Walker, L, Phillips, L, Colon, SM, Miles, C, Chesnut, RW, Sette, A

“…This study describes the establishment of a peptide-binding assay for purified, detergent-solubilized DR molecules. For each of the DR specificities and…”
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Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for IAs molecules by Lamont, AG, Sette, A, Fujinami, R, Colon, SM, Miles, C, Grey, HM

“…Blocking of the Ag presenting function of MHC by peptides capable of high affinity binding to this molecule has been proposed as a potential immunotherapeutic…”
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Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition by Krieger, JI, Karr, RW, Grey, HM, Yu, WY, O'Sullivan, D, Batovsky, L, Zheng, ZL, Colon, SM, Gaeta, FC, Sidney, J

“…Single amino acid substitutions of Ag and MHC were used to analyze the fine structure of the influenza hemagglutinin (HA)-derived epitope (HA 307-319)…”
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Autologous Peptides Constitutively Occupy the Antigen Binding Site on Ia by Buus, Soren, Sette, Alessandro, Colon, Sonia M., Grey, Howard M.

“…Low molecular weight material associated with affinity-purified class II major histocompatibility complex (MHC) molecules of mouse (Ia) had the expected…”
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Capacity of intact proteins to bind to MHC class II molecules by Sette, A, Adorini, L, Colon, SM, Buus, S, Grey, HM

“…Here we have demonstrated that denatured, but not native protein antigens can interact with Ia molecules. Thus, the failure of native antigens to be recognized…”
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Structural requirements for the interaction between peptide antigens and I-Ed molecules by Sette, A, Adorini, L, Appella, E, Colon, SM, Miles, C, Tanaka, S, Ehrhardt, C, Doria, G, Nagy, ZA, Buus, S

“…We have analyzed the structural characteristics of the interaction between I-Ed molecules and their peptide ligands. It was found that unrelated good I-Ed…”
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Truncation analysis of several DR binding epitopes by O'Sullivan, D, Sidney, J, Del Guercio, MF, Colon, SM, Sette, A

“…Peptide regions crucial for binding to four different DR alleles (DR1, DR2, DR5, and DR52a) have been localized in five unrelated DR binding peptides…”
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The use of peptide analogs with improved stability and MHC binding capacity to inhibit antigen presentation in vitro and in vivo by Lamont, AG, Powell, MF, Colon, SM, Miles, C, Grey, HM, Sette, A

“…The identification of a core region for OVA 323-339, which is critical in determining binding to IAd, has enabled us to generate a series of analog peptides in…”
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Antigen presentation by normal B cells, B cell tumors, and macrophages: functional and biochemical comparison by Chesnut, R W, Colon, S M, Grey, H M

“…The authors have made a comparative study of the capacity of normal B cells, B lymphoma cells, and splenic macrophages to present the antigen KLH, either to a…”
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A novel approach to the generation of high affinity class II-binding peptides by Sette, A, Sidney, J, Albertson, M, Miles, C, Colon, SM, Pedrazzini, T, Lamont, AG, Grey, HM

“…We have found that if core regions crucial for class II binding are incorporated in multiple copies in the same peptide molecule ("reiterative motifs"), marked…”
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High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants by Wall, M, Southwood, S, Sidney, J, Oseroff, C, del Guericio, M F, Lamont, A G, Colón, S M, Arrhenius, T, Gaeta, F C, Sette, A

“…A direct binding assay specific for IAs molecules has been developed and its immunological relevance validated by examining, for a panel of nine different…”
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