Search Results - "Colon, Beatrice L"

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae by Rice, Christopher A, Colon, Beatrice L, Chen, Emily, Hull, Mitchell V, Kyle, Dennis E

“…Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis…”
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Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium by Hanna, Jack C, Corpas-Lopez, Victor, Seizova, Simona, Colon, Beatrice L, Bacchetti, Ross, Hall, Grant M J, Sands, Emma M, Robinson, Lee, Baragaña, Beatriz, Wyllie, Susan, Pawlowic, Mattie C

“…Cryptosporidiosis is a leading cause of diarrheal-associated morbidity and mortality, predominantly affecting children under 5 years old in…”
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Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research by Kent, Robyn S, Briggs, Emma M, Colon, Beatrice L, Alvarez, Catalina, Silva Pereira, Sara, De Niz, Mariana

“…In the age of big data an important question is how to ensure we make the most out of the resources we generate. In this review, we discuss the major methods…”
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Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery by Demers, Danielle H, Knestrick, Matthew A, Fleeman, Renee, Tawfik, Rahmy, Azhari, Ala, Souza, Ashley, Vesely, Brian, Netherton, Mandy, Gupta, Rashmi, Colon, Beatrice L, Rice, Christopher A, Rodríguez-Pérez, Mario A, Rohde, Kyle H, Kyle, Dennis E, Shaw, Lindsey N, Baker, Bill J

“…There is an acute need for new and effective agents to treat infectious diseases. We conducted a screening program to assess the potential of mangrove-derived…”
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Blood flukes Cardicola parvus and C. laruei (Trematoda: Aporocotylidae): life cycles and cryptic infection in spotted seatrout, Cynoscion nebulosus (Teleost: Sciaenidae) by Siegel, Sasha V., Rivero, Andrea V., Oberstaller, Jenna, Colon, Beatrice L., de Buron, Isaure, Kyle, Dennis E.

“…Aporocotylidae comprises a diverse family of fish blood flukes, with adults found in blood or body cavity of marine, brackish, or freshwater fish…”
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Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis by Colon, Beatrice L, Rice, Christopher A, Guy, R Kiplin, Kyle, Dennis E

“…Naegleria fowleri is the causative agent of primary amoebic meningoencephalitis (PAM), which is fatal in >97% of cases. In this study, we aimed to identify…”
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First evidence of polychaete intermediate hosts for Neospirorchis spp. marine turtle blood flukes (Trematoda: Spirorchiidae) by de Buron, Isaure, Colon, Beatrice L., Siegel, Sasha V., Oberstaller, Jenna, Rivero, Andrea, Kyle, Dennis E.

“…[Display omitted] •There are few known life cycles for spirorchiids and all use mollusks as intermediate hosts.•Sporocysts and spirorchiid-like cercariae were…”
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Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens by Rice, Christopher A, Colon, Beatrice L, Alp, Mehmet, Göker, Hakan, Boykin, David W, Kyle, Dennis E

“…Naegleria fowleri is a pathogenic free-living amoeba (FLA) that causes an acute fatal disease known as primary amoebic meningoencephalitis (PAM). The major…”
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Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy by Caldwell, Nicola, Peet, Caroline, Miller, Peter, Colon, Beatrice L, Taylor, Malcolm G, Cocco, Mattia, Dawson, Alice, Lukac, Iva, Teixeira, Jose E, Robinson, Lee, Frame, Laura, Seizova, Simona, Damerow, Sebastian, Tamaki, Fabio, Post, John, Riley, Jennifer, Mutter, Nicole, Hanna, Jack C, Ferguson, Liam, Hu, Xiao, Tinti, Michele, Forte, Barbara, Norcross, Neil R, Campbell, Peter S, Svensen, Nina, Caldwell, Flora C, Jansen, Chimed, Postis, Vincent, Read, Kevin D, Huston, Christopher D, Gilbert, Ian H, Baragaña, Beatriz, Pawlowic, Mattie C

“…Cryptosporidiosis is a diarrheal disease caused by infection with spp. parasites and is a leading cause of death in malnourished children worldwide. The only…”
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Postzygotic Isolation Evolves before Prezygotic Isolation between Fresh and Saltwater Populations of the Rainwater Killifish, Lucania parva by Kozak, Genevieve M., Rudolph, Arthur B., Colon, Beatrice L., Fuller, Rebecca C.

“…Divergent natural selection has the potential to drive the evolution of reproductive isolation. The euryhaline killifish Lucania parva has stable populations…”
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond by Van Voorhis, Wesley C, Adams, John H, Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H, Alano, Pietro, Alday, Aintzane, Alemán Resto, Yesmalie, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T, Avery, Simon V, Avery, Vicky M, Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bhatia, Sangeeta, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E, Boyom, Fabrice F, Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R, Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Belen Cassera, Maria, Chih-Chien Cheng, Ken, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L, Colón-López, Daisy D, Corbett, Yolanda, Crowther, Gregory J, Cowan, Noemi, D'Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L, Du, Alan Y, Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T, Fernández Robledo, José A, Fidock, David A, Florent, Isabelle, Fokou, Patrick V T, Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M, Guha, Rajarshi, Guiguemde, W Armand, Gural, Nil, Guy, R Kiplin, Hansen, Michael A E, Hanson, Kirsten K, Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B, Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A, Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T, Jiang, Rays H Y, Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P, Kyle, Dennis E, Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M, Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I, Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu

“…A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in…”
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