Search Results - "Colmont, Chantal"

IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3 by Fielding, Ceri A, McLoughlin, Rachel M, McLeod, Louise, Colmont, Chantal S, Najdovska, Meri, Grail, Dianne, Ernst, Matthias, Jones, Simon A, Topley, Nicholas, Jenkins, Brendan J

“…The successful resolution of inflammation is dependent upon the coordinated transition from the initial recruitment of neutrophils to a more sustained…”
Get full text

Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections by Zhang, Jingjing, Friberg, Ida M, Kift-Morgan, Ann, Parekh, Gita, Morgan, Matt P, Liuzzi, Anna Rita, Lin, Chan-Yu, Donovan, Kieron L, Colmont, Chantal S, Morgan, Peter H, Davis, Paul, Weeks, Ian, Fraser, Donald J, Topley, Nicholas, Eberl, Matthias

“…The immune system has evolved to sense invading pathogens, control infection, and restore tissue integrity. Despite symptomatic variability in patients,…”
Get more information

Toll-Like Receptors 2 and 4 Are Potential Therapeutic Targets in Peritoneal Dialysis-Associated Fibrosis by Raby, Anne-Catherine, Colmont, Chantal S, Kift-Morgan, Ann, Köhl, Jörg, Eberl, Matthias, Fraser, Donald, Topley, Nicholas, Labéta, Mario O

“…Peritoneal dialysis (PD) remains limited by dialysis failure due to peritoneal membrane fibrosis driven by inflammation caused by infections or sterile…”
Get full text

Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling by Liuzzi, Anna Rita, Kift-Morgan, Ann, Lopez-Anton, Melisa, Friberg, Ida M, Zhang, Jingjing, Brook, Amy C, Roberts, Gareth W, Donovan, Kieron L, Colmont, Chantal S, Toleman, Mark A, Bowen, Timothy, Johnson, David W, Topley, Nicholas, Moser, Bernhard, Fraser, Donald J, Eberl, Matthias

“…The antimicrobial responsiveness and function of unconventional human T cells are poorly understood, with only limited access to relevant specimens from sites…”
Get full text

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation by Fielding, Ceri A., Jones, Gareth W., McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S., Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D., Williams, Geraint T., Davies, Simon J., Humphreys, Ian R., O’Donnell, Valerie B., Taylor, Philip R., Jenkins, Brendan J., Topley, Nicholas, Jones, Simon A.

“…Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark of many chronic degenerative diseases. By using a model of acute…”
Get full text

Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens by Raby, Anne-Catherine, Holst, Benjamin, Le Bouder, Emmanuel, Diaz, Constantino, Ferran, Edgardo, Conraux, Laurence, Guillemot, Jean-Claude, Coles, Barbara, Kift-Morgan, Ann, Colmont, Chantal S, Szakmany, Tamas, Ferrara, Pascual, Hall, Judith E, Topley, Nicholas, Labéta, Mario O

“…Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsiveness and susceptibility to…”
Get more information

Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors by Colmont, Chantal S., Raby, Anne-Catherine, Dioszeghy, Vincent, LeBouder, Emmanuel, Foster, Thomas L., Jones, Simon A., Labéta, Mario O., Fielding, Ceri A., Topley, Nicholas

“…Background. Bacterial infection remains a major cause of morbidity and mortality in peritoneal dialysis (PD) patients worldwide. Previous studies have…”
Get full text

TLR activation enhances C5a‐induced pro‐inflammatory responses by negatively modulating the second C5a receptor, C5L2 by Raby, Anne‐Catherine, Holst, Benjamin, Davies, James, Colmont, Chantal, Laumonnier, Yves, Coles, Barbara, Shah, Sanjoy, Hall, Judith, Topley, Nicholas, Köhl, Jörg, Morgan, B. Paul, Labéta, Mario O.

“…TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the…”
Get full text

CD200-expressing human basal cell carcinoma cells initiate tumor growth by Colmont, Chantai S., BenKetah, Antisar, Reed, Simon H., Hawk, Nga V., Telford, William G., Ohyama, Manabu, Udey, Mark C., Yee, Carole L., Vogel, Jonathan C., Patel, Girish K.

“…Smoothened antagonists directly target the genetic basis of human basal cell carcinoma (BCC), the most common of all cancers. These drugs inhibit BCC growth,…”
Get full text

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering by Raby, Anne-Catherine, Le Bouder, Emmanuel, Colmont, Chantal, Davies, James, Richards, Peter, Coles, Barbara, George, Christopher H, Jones, Simon A, Brennan, Paul, Topley, Nicholas, Labeta, Mario O

“…TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to…”
Get full text

12/15-Lipoxygenase Regulates the Inflammatory Response to Bacterial Products In Vivo by Dioszeghy, Vincent, Rosas, Marcela, Maskrey, Benjamin H, Colmont, Chantal, Topley, Nicholas, Chaitidis, Pavlos, Kuhn, Hartmut, Jones, Simon A, Taylor, Philip R, O'Donnell, Valerie B

“…The peritoneal macrophage (Mphi) is the site of greatest 12/15-lipoxygenase (12/15-LOX) expression in the mouse; however, its immunoregulatory role in this…”
Get full text

Human skin cancer stem cells: a tale of mice and men by Colmont, Chantal S., Harding, Keith G., Piguet, Vincent, Patel, Girish K.

“…Carcinomas, cancers of epithelial tissues, are the commonest malignancies and cause the greatest cancer mortality worldwide. Among these, the incidence of…”
Get full text

Human Basal Cell Carcinoma Tumor-Initiating Cells Are Resistant to Etoposide by Colmont, Chantal S., Ketah, Antisar B., Errington, Rachel J., Reed, Simon H., Udey, Mark C., Patel, Girish K.

Get full text

Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation by Hams, Emily, Colmont, Chantal S, Dioszeghy, Vincent, Hammond, Victoria J, Fielding, Ceri A, Williams, Anwen S, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip R, Topley, Nicholas, Jones, Simon A

“…Although the IL-6-related cytokine oncostatin M (OSM) affects processes associated with disease progression, the specific function of OSM in the face of an…”
Get full text

Viral IL-6 Blocks Neutrophil Infiltration during Acute Inflammation by Fielding, Ceri A, McLoughlin, Rachel M, Colmont, Chantal S, Kovaleva, Marina, Harris, Dean A, Rose-John, Stefan, Topley, Nicholas, Jones, Simon A

“…Pathologies arising as a consequence of human herpesvirus-8 (HHV8) infections are closely associated with the autocrine activity of a HHV8 encoded IL-6…”
Get full text

Receptor-interacting protein-2 deficiency delays macrophage migration and increases intracellular infection during peritoneal dialysis-associated peritonitis by McCully, Michelle L, Fairhead, Todd, Colmont, Chantal S, Beasley, Federico C, Heinrichs, David E, Blake, Peter G, Topley, Nicholas, Madrenas, Joaquín

“…Early upregulation of receptor-interacting protein-2 (RIP2) expression during peritoneal dialysis (PD)-associated peritonitis correlates with a favorable…”
Get more information

Extracellular Export of Sphingosine Kinase-1 Enzyme by Ancellin, Nicolas, Colmont, Chantal, Su, Joseph, Li, Qin, Mittereder, Nanette, Chae, Sung-Suk, Stefansson, Steingrimur, Liau, Gene, Hla, Timothy

“…The enzyme sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that acts extracellularly on G protein-coupled…”
Get full text

IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata by Damgov, Ivan, Bartosova, Maria, Marinovic, Iva, Istanbuly, Obaida, Kieser, Meinhard, Lambie, Mark, Davies, Simon J., Schmitt, Claus Peter, Vychytil, Andreas, Raby, Anne-Catherine, Colmont, Chantal, Aufricht, Cristoph, Johnson, David W., Fraser, Donald, Eringa, Ed, Morelle, Johann, Valdivielso, Jose M., Kratochwill, Klaus, Jakulj, Lily, Vervloet, Marc, Ruiz-Ortega, Marta, Devuyst, Olivier, Rossignol, Patrick, Rutherford, Peter, Herzog, Rebecca, Meran, Soma

Get full text

Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation by Ancellin, Nicolas, Colmont, Chantal, Su, Joseph, Li, Qin, Mittereder, Nanette, Chae, Sung-Suk, Stefansson, Steingrimur, Liau, Gene, Hla, Timothy

“…The enzyme sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that acts extracellularly on G protein-coupled…”
Get full text

Investigation of the Role of Toll-Like and Interleukin-6 Receptors in Peritoneal Inflammatory Responses to Infection by Colmont, Chantal Sophie Francoise

“…Bacterial infection is a feature of long-term peritoneal dialysis (PD) and a cause of loss of peritoneal function and treatment failure. Understanding how…”
Get full text