Search Results - "Colmenares, Serafin U"

Heterochromatin: Guardian of the Genome by Janssen, Aniek, Colmenares, Serafin U, Karpen, Gary H

“…Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at…”
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Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair by Chiolo, Irene, Minoda, Aki, Colmenares, Serafin U., Polyzos, Aris, Costes, Sylvain V., Karpen, Gary H.

“…Double-strand breaks (DSBs) in heterochromatic repetitive DNAs pose significant threats to genome integrity, but information about how such lesions are…”
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Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A by Janssen, Aniek, Colmenares, Serafin U, Lee, Timothy, Karpen, Gary H

“…Repair of DNA double-strand breaks (DSBs) must be orchestrated properly within diverse chromatin domains in order to maintain genetic stability. Euchromatin…”
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DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5 by Kendek, Apfrida, Sandron, Arianna, Lambooij, Jan-Paul, Colmenares, Serafin U, Pociunaite, Severina M, Gooijers, Iris, de Groot, Lars, Karpen, Gary H, Janssen, Aniek

“…Cells employ diverse strategies to repair double-strand breaks (DSBs), a dangerous form of DNA damage that threatens genome integrity. Eukaryotic nuclei…”
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Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair by Wensveen, Marieke R., Dixit, Aditya A., van Schendel, Robin, Kendek, Apfrida, Lambooij, Jan-Paul, Tijsterman, Marcel, Colmenares, Serafin U., Janssen, Aniek

“…DNA double-strand breaks (DSBs) must be properly repaired within diverse chromatin domains to maintain genome stability. Whereas euchromatin has an open…”
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Assembly of Drosophila Centromeric Nucleosomes Requires CID Dimerization by Zhang, Weiguo, Colmenares, Serafin U., Karpen, Gary H.

“…Centromeres are essential chromosomal regions required for kinetochore assembly and chromosome segregation. The composition and organization of centromeric…”
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Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila by Kasinathan, Bhavatharini, Colmenares, 3rd, Serafin U, McConnell, Hannah, Young, Janet M, Karpen, Gary H, Malik, Harmit S

“…Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic genes, which encode the most…”
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Two RNAi Complexes, RITS and RDRC, Physically Interact and Localize to Noncoding Centromeric RNAs by Motamedi, Mohammad R., Verdel, André, Colmenares, Serafin U., Gerber, Scott A., Gygi, Steven P., Moazed, Danesh

“…RNAi-mediated heterochromatin assembly in fission yeast requires the RNA-induced transcriptional silencing (RITS) complex and a putative RNA-directed RNA…”
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The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic by Swenson, Joel M, Colmenares, Serafin U, Strom, Amy R, Costes, Sylvain V, Karpen, Gary H

“…Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions. To…”
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Coupling of Double-Stranded RNA Synthesis and siRNA Generation in Fission Yeast RNAi by Colmenares, Serafin U., Buker, Shane M., Buhler, Marc, Dlakić, Mensur, Moazed, Danesh

“…The fission yeast centromeric repeats are transcribed and ultimately processed into small interfering RNAs (siRNAs) that are required for heterochromatin…”
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Rapid Evolution of Gained Essential Developmental Functions of a Young Gene via Interactions with Other Essential Genes by Lee, Yuh Chwen G, Ventura, Iuri M, Rice, Gavin R, Chen, Dong-Yuan, Colmenares, Serafin U, Long, Manyuan

“…Abstract New genes are of recent origin and only present in a subset of species in a phylogeny. Accumulated evidence suggests that new genes, like old genes…”
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Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity by Colmenares, Serafin U., Swenson, Joel M., Langley, Sasha A., Kennedy, Cameron, Costes, Sylvain V., Karpen, Gary H.

“…Eukaryotic genomes are broadly divided between gene-rich euchromatin and the highly repetitive heterochromatin domain, which is enriched for proteins critical…”
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FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein by Morrison, Debra J., Pendergrast, P. Shannon, Stavropoulos, Peter, Colmenares, Serafin U., Kobayashi, Ryuji, Hernandez, Nouria

“…The HIV-1 promoter directs the synthesis of two classes of transcripts, short, non-polyadenylated transcripts and full-length, polyadenylated transcripts. The…”
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Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A by Janssen, Aniek, Colmenares, Serafin U., Lee, Timothy, Karpen, Gary H.

“…Repair of DNA double-strand breaks (DSBs) must be orchestrated properly within diverse chromatin domains in order to maintain genetic stability. Euchromatin…”
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The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic by Swenson, Joel M., Colmenares, Serafin U., Strom, Amy R., Costes, Sylvain V., Karpen, Gary H.

“…Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions. To…”
Get full text

Studies on the mechanism of RNAi-dependent heterochromatin assembly by Moazed, D, Bühler, M, Buker, S M, Colmenares, S U, Gerace, E L, Gerber, S A, Hong, E-J E, Motamedi, M R, Verdel, A, Villén, J, Gygi, S P

“…Assembly of heterochromatin at centromeric DNA regions in the fission yeast Schizosaccharomyces pombe involves an intimate interplay between chromatin…”
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