Search Results - "Collis, J."

DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies by Rominiyi, Ola, Collis, Spencer J.

“…Glioblastoma is the most frequently diagnosed type of primary brain tumour in adults. These aggressive tumours are characterised by inherent treatment…”
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Low-Dose Hyper-Radiosensitivity: Past, Present, and Future by Marples, Brian, Ph.D, Collis, Spencer J., Ph.D

“…This review article discusses the biology of low-dose hyper-radiosensitivity (HRS) with reference to the molecular regulation of DNA repair and cell cycle…”
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Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia by Adamo, Adele, Collis, Spencer J., Adelman, Carrie A., Silva, Nicola, Horejsi, Zuzana, Ward, Jordan D., Martinez-Perez, Enrique, Boulton, Simon J., La Volpe, Adriana

“…Fanconi anemia (FA) is a complex cancer susceptibility disorder associated with DNA repair defects and infertility, yet the precise function of the FA proteins…”
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RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination by Barber, Louise J., Youds, Jillian L., Ward, Jordan D., McIlwraith, Michael J., O'Neil, Nigel J., Petalcorin, Mark I.R., Martin, Julie S., Collis, Spencer J., Cantor, Sharon B., Auclair, Melissa, Tissenbaum, Heidi, West, Stephen C., Rose, Ann M., Boulton, Simon J.

“…Homologous recombination (HR) is an important conserved process for DNA repair and ensures maintenance of genome integrity. Inappropriate HR causes gross…”
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EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7 by O'Regan, Laura, Barone, Giancarlo, Adib, Rozita, Woo, Chang Gok, Jeong, Hui Jeong, Richardson, Emily L, Richards, Mark W, Muller, Patricia A J, Collis, Spencer J, Fennell, Dean A, Choi, Jene, Bayliss, Richard, Fry, Andrew M

“…EML4-ALK is an oncogenic fusion present in ∼5% of non-small cell lung cancers. However, alternative breakpoints in the gene lead to distinct variants of…”
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CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability by Hořejší, Zuzana, Takai, Hiroyuki, Adelman, Carrie A., Collis, Spencer J., Flynn, Helen, Maslen, Sarah, Skehel, J. Mark, de Lange, Titia, Boulton, Simon J.

“…TEL2 interacts with and is essential for the stability of all phosphatidylinositol 3-kinase-related kinases (PIKKs), but its mechanism of action remains…”
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17 years' experience of surgical management of thoracic outlet syndrome at a district general hospital by Farquharson, BJMc, Collis, J, Jaskani, S, Bergman, H, Andrews, B

“…Thoracic outlet syndrome (TOS) is caused by compression of the neurovascular structures passing through the thoracic inlet. It is categorised into three…”
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Effective equations governing an active poroelastic medium by Collis, J., Brown, D. L., Hubbard, M. E., O’Dea, R. D.

“…In this work, we consider the spatial homogenization of a coupled transport and fluid–structure interaction model, to the end of deriving a system of effective…”
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The life and death of DNA-PK by COLLIS, Spencer J, DEWEESE, Theodore L, JEGGO, Penelope A, PARKER, Antony R

“…Double-strand breaks (DSBs) arise endogenously during normal cellular processes and exogenously by genotoxic agents such as ionizing radiation (IR). DSBs are…”
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High quality genome annotation and expression visualisation of a mupirocin-producing bacterium by Haines, Anthony S, Kendrew, Steve G, Crowhurst, Nicola, Stephens, Elton R, Connolly, Jack, Hothersall, Joanne, Miller, Claire E, Collis, Andrew J, Huckle, Benjamin D, Thomas, Christopher M

“…Pseudomonas strain NCIMB10586, in the P. fluorescens subgroup, produces the polyketide antibiotic mupirocin, and has potential as a host for industrial…”
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Research Note: How Valuable are Organizational Capabilities? by Collis, David J.

“…Organizational capabilities, appropriately defined, can meet the conditions, articulated by the resource-based view of the firm, for being a source of…”
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FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex by Collis, Spencer J., Ciccia, Alberto, Deans, Andrew J., Hořejší, Zuzana, Martin, Julie S., Maslen, Sarah L., Skehel, J. Mark, Elledge, Stephen J., West, Stephen C., Boulton, Simon J.

“…The Fanconi anemia (FA) pathway is implicated in DNA repair and cancer predisposition. Central to this pathway is the FA core complex, which is targeted to…”
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Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor by Kachhap, Sushant K, Rosmus, Nadine, Collis, Spencer J, Kortenhorst, Madeleine S Q, Wissing, Michel D, Hedayati, Mohammad, Shabbeer, Shabana, Mendonca, Janet, Deangelis, Justin, Marchionni, Luigi, Lin, Jianqing, Höti, Naseruddin, Nortier, Johan W R, DeWeese, Theodore L, Hammers, Hans, Carducci, Michael A

“…Histone deacetylase inhibitors (HDACis) re-express silenced tumor suppressor genes and are currently undergoing clinical trials. Although HDACis have been…”
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The centriolar satellite protein Cep131 is important for genome stability by Staples, Christopher J, Myers, Katie N, Beveridge, Ryan D D, Patil, Abhijit A, Lee, Alvin J X, Swanton, Charles, Howell, Michael, Boulton, Simon J, Collis, Spencer J

“…The centrosome acts as a centre for microtubule organisation and plays crucial roles in cell polarity, migration, growth and division. Cep131 has recently been…”
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MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response by Staples, Christopher J., Barone, Giancarlo, Myers, Katie N., Ganesh, Anil, Gibbs-Seymour, Ian, Patil, Abhijit A., Beveridge, Ryan D., Daye, Caroline, Beniston, Richard, Maslen, Sarah, Ahel, Ivan, Skehel, J. Mark, Collis, Spencer J.

“…Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor…”
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Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients [version 2; peer review: 2 approved] by Gagg, Hannah, Williams, Sophie T., Conroy, Samantha, Myers, Katie N., McGarrity-Cottrell, Connor, Jones, Callum, Helleday, Thomas, Rantala, Juha, Rominiyi, Ola, Danson, Sarah J., Collis, Spencer J., Wells, Greg

“…With diminishing returns and high clinical failure rates from traditional preclinical and animal-based drug discovery strategies, more emphasis is being placed…”
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Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma by Carmell, Natasha, Rominiyi, Ola, Myers, Katie N, McGarrity-Cottrell, Connor, Vanderlinden, Aurelie, Lad, Nikita, Perroux-David, Eva, El-Khamisy, Sherif F, Fernando, Malee, Finegan, Katherine G, Brown, Stephen, Collis, Spencer J

“…Brain tumours kill more children and adults under 40 than any other cancer, with approximately half of primary brain tumours being diagnosed as high-grade…”
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Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability by Staples, Christopher J, Myers, Katie N, Beveridge, Ryan D D, Patil, Abhijit A, Howard, Anna E, Barone, Giancarlo, Lee, Alvin J X, Swanton, Charles, Howell, Michael, Maslen, Sarah, Skehel, J Mark, Boulton, Simon J, Collis, Spencer J

“…Here, we identify coiled-coil domain-containing protein 13 (Ccdc13) in a genome-wide RNA interference screen for regulators of genome stability. We establish…”
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Tophaceous joint disease strongly predicts hand function in patients with gout by Dalbeth, N., Collis, J., Gregory, K., Clark, B., Robinson, E., McQueen, F. M.

“…Objectives. The functional impact of gout is poorly understood. The aim of this study was to determine predictors of hand function in gout. Methods. Twenty…”
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DOG-1 Is the Caenorhabditis elegans BRIP1/FANCJ Homologue and Functions in Interstrand Cross-Link Repair by Youds, Jillian L., Barber, Louise J., Ward, Jordan D., Collis, Spencer J., O'Neil, Nigel J., Boulton, Simon J., Rose, Ann M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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