Search Results - "Collins, Sierra M."

Efficient engineering of human and mouse primary cells using peptide-assisted genome editing by Zhang, Zhen, Baxter, Amy E., Ren, Diqiu, Qin, Kunhua, Chen, Zeyu, Collins, Sierra M., Huang, Hua, Komar, Chad A., Bailer, Peter F., Parker, Jared B., Blobel, Gerd A., Kohli, Rahul M., Wherry, E. John, Berger, Shelley L., Shi, Junwei

“…Simple, efficient and well-tolerated delivery of CRISPR genome editing systems into primary cells remains a major challenge. Here we describe an engineered…”
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Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell-Intrinsic Dysfunction by Jung, In-Young, Bartoszek, Robert L, Rech, Andrew J, Collins, Sierra M, Ooi, Soon-Keat, Williams, Erik F, Hopkins, Caitlin R, Narayan, Vivek, Haas, Naomi B, Frey, Noelle V, Hexner, Elizabeth O, Siegel, Donald L, Plesa, Gabriela, Porter, David L, Cantu, Adrian, Everett, John K, Guedan, Sonia, Berger, Shelley L, Bushman, Frederic D, Herbst, Friederike, Fraietta, Joseph A

“…Chimeric antigen receptor (CAR) T cell therapy has shown promise in treating hematologic cancers, but resistance is common and efficacy is limited in solid…”
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TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells by Collins, Sierra M, Alexander, Katherine A, Lundh, Stefan, Dimitri, Alexander J, Zhang, Zhen, Good, Charly R, Fraietta, Joseph A, Berger, Shelley L

“…Chimeric antigen receptor (CAR) T cell therapy is used in treating human hematological malignancies, but its efficacy is limited by T cell exhaustion (T ). T…”
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Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors by Jung, In-Young, Noguera-Ortega, Estela, Bartoszek, Robert, Collins, Sierra M., Williams, Erik, Davis, Megan, Jadlowsky, Julie K., Plesa, Gabriela, Siegel, Donald L., Chew, Anne, Levine, Bruce L., Berger, Shelley L., Moon, Edmund K., Albelda, Steven M., Fraietta, Joseph A.

“…Chimeric antigen receptor (CAR) T cells demonstrate remarkable success in treating hematological malignancies, but their effectiveness in non-hematopoietic…”
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