Search Results - "Collins, Sheila"

Regulation of mTOR Signaling: Emerging Role of Cyclic Nucleotide-Dependent Protein Kinases and Implications for Cardiometabolic Disease by Shi, Fubiao, Collins, Sheila

“…The mechanistic target of rapamycin (mTOR) kinase is a central regulator of cell growth and metabolism. It is the catalytic subunit of two distinct large…”
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Exercise performance is not improved in mice with skeletal muscle deletion of natriuretic peptide clearance receptor by Jia, Brigitte, Hasse, Alexander, Shi, Fubiao, Collins, Sheila

“…Natriuretic peptides (NP), including atrial, brain, and C-type natriuretic peptides (ANP, BNP, and CNP), play essential roles in regulating blood pressure,…”
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Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes by Bordicchia, Marica, Liu, Dianxin, Amri, Ez-Zoubir, Ailhaud, Gerard, Dessì-Fulgheri, Paolo, Zhang, Chaoying, Takahashi, Nobuyuki, Sarzani, Riccardo, Collins, Sheila

“…The ability of mammals to resist body fat accumulation is linked to their ability to expand the number and activity of "brown adipocytes" within white fat…”
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Second messenger signaling mechanisms of the brown adipocyte thermogenic program: an integrative perspective by Shi, Fubiao, Collins, Sheila

“…β-adrenergic receptors (βARs) are well established for conveying the signal from catecholamines to adipocytes. Acting through the second messenger cyclic…”
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Cardiac natriuretic peptides promote adipose ‘browning’ through mTOR complex-1 by Liu, Dianxin, Ceddia, Ryan P., Collins, Sheila

“…Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white…”
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Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein by Park, Daeho, Han, Claudia Z., Elliott, Michael R., Kinchen, Jason M., Trampont, Paul C., Das, Soumita, Collins, Sheila, Lysiak, Jeffrey J., Hoehn, Kyle L., Ravichandran, Kodi S.

“…How phagocytes keep their appetite When a phagocyte engulfs a dying cell, it essentially doubles its cellular contents, yet phagocytes are capable of ingesting…”
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Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis by YEHUDA-SHNAIDMAN, Einav, BUEHRER, Ben, JINGBO PI, KUMAR, Naresh, COLLINS, Sheila

“…We examined the effect of β-adrenergic receptor (βAR) activation and cAMP-elevating agents on respiration and mitochondrial uncoupling in human adipocytes and…”
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Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3 by Mailloux, Ryan J., Seifert, Erin L., Bouillaud, Frédéric, Aguer, Céline, Collins, Sheila, Harper, Mary-Ellen

“…The mitochondrial uncoupling proteins 2 and 3 (UCP2 and -3) are known to curtail oxidative stress and participate in a wide array of cellular functions,…”
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Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration by Guilherme, Adilson, Yenilmez, Batuhan, Bedard, Alexander H., Henriques, Felipe, Liu, Dianxin, Lee, Alexandra, Goldstein, Lauren, Kelly, Mark, Nicoloro, Sarah M., Chen, Min, Weinstein, Lee, Collins, Sheila, Czech, Michael P.

“…Here, we show that β adrenergic signaling coordinately upregulates de novo lipogenesis (DNL) and thermogenesis in subcutaneous white adipose tissue (sWAT), and…”
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Measuring respiratory activity of adipocytes and adipose tissues in real time by Bugge, Anne, Dib, Lea, Collins, Sheila

“…The realization that obesity and its associated diseases have become one of modern society's major challenges to the health of the world's population has…”
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Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion by JINGBO PI, YUSHI BAI, COLLINS, Sheila, QIANG ZHANG, WONG, Victoria, FLOERING, Lisa M, DANIEL, Kiefer, FLEECE, Jeffrey M, DEENEY, Jude T, ANDERSEN, Melvin E, CORKEY, Barbara E

“…Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion Jingbo Pi 1 , Yushi Bai 1 , Qiang Zhang 2 , Victoria Wong 3 , Lisa M. Floering 1 ,…”
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ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function by Pi, Jingbo, Zhang, Qiang, Fu, Jingqi, Woods, Courtney G., Hou, Yongyong, Corkey, Barbara E., Collins, Sheila, Andersen, Melvin E.

“…This review focuses on the emerging evidence that reactive oxygen species (ROS) derived from glucose metabolism, such as H 2O 2, act as metabolic signaling…”
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Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity by Ceddia, Ryan P, Zurawski, Zack, Thompson Gray, Analisa, Adegboye, Feyisayo, McDonald-Boyer, Ainsley, Shi, Fubiao, Liu, Dianxin, Maldonado, Jose, Feng, Jiesi, Li, Yulong, Alford, Simon, Ayala, Julio E, McGuinness, Owen P, Collins, Sheila, Hamm, Heidi E

“…Negative regulation of exocytosis from secretory cells is accomplished through inhibitory signals from Gi/o GPCRs by Gβγ subunit inhibition of 2 mechanisms:…”
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LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes[S] by Dib, Lea, Bugge, Anne, Collins, Sheila

“…Liver X receptors (LXRs) are transcription factors known for their role in hepatic cholesterol and lipid metabolism. Though highly expressed in fat, the role…”
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Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress by Fu, Jingqi, Woods, Courtney G., Yehuda-Shnaidman, Einav, Zhang, Qiang, Wong, Victoria, Collins, Sheila, Sun, Guifan, Andersen, Melvin E., Pi, Jingbo

“…BACKGROUND: Chronic exposure of humans to inorganic arsenic, a potent environmental oxidative Stressor, is associated with incidence of type 2 diabetes (T2D)…”
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The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation by Fischer, Katrin, Fenzl, Anna, Liu, Dianxin, Dyar, Kenneth A., Kleinert, Maximilian, Brielmeier, Markus, Clemmensen, Christoffer, Fedl, Anna, Finan, Brian, Gessner, Andre, Jastroch, Martin, Huang, Jianfeng, Keipert, Susanne, Klingenspor, Martin, Brüning, Jens C., Kneilling, Manfred, Maier, Florian C., Othman, Ahmed E., Pichler, Bernd J., Pramme-Steinwachs, Ines, Sachs, Stephan, Scheideler, Angelika, Thaiss, Wolfgang M., Uhlenhaut, Henriette, Ussar, Siegfried, Woods, Stephen C., Zorn, Julia, Stemmer, Kerstin, Collins, Sheila, Diaz-Meco, Maria, Moscat, Jorge, Tschöp, Matthias H., Müller, Timo D.

“…During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the…”
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Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide by Le, Thao D V, Liu, Dianxin, Besing, Gai-Linn K, Raghavan, Ritika, Ellis, Blair J, Ceddia, Ryan P, Collins, Sheila, Ayala, Julio E

“…The canonical target of the glucagon-like peptide-1 receptor (GLP-1R), Protein Kinase A (PKA), has been shown to stimulate mechanistic Target of Rapamycin…”
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β-Adrenergic Receptors and Adipose Tissue Metabolism: Evolution of an Old Story by Collins, Sheila

“…The role of β-adrenergic receptors (βARs) in adipose tissue to promote lipolysis and the release of fatty acids and nonshivering thermogenesis in brown fat has…”
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Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning by Shi, Fubiao, de Fatima Silva, Flaviane, Liu, Dianxin, Patel, Hari U., Xu, Jonathan, Zhang, Wei, Türk, Clara, Krüger, Marcus, Collins, Sheila

“…Norepinephrine stimulates the adipose tissue thermogenic program through a β-adrenergic receptor (βAR)–cyclic adenosine monophosphate (cAMP)–protein kinase A…”
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Correlates of Plasma NT-proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial by Chiu, Leonard, Agrawal, Vineet, Armstrong, David, Brittain, Evan, Collins, Sheila, Hemnes, Anna R, Hill, Joseph A, Lindenfeld, JoAnn, Shah, Sanjiv J, Stevenson, Lynne W, Wang, Thomas J, Gupta, Deepak K

“…Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic…”
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