Search Results - "Collins, Mark A."

Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget by Fensome, Andrew, Bender, Reinhold, Chopra, Rajiv, Cohen, Jeff, Collins, Mark A, Hudak, Valerie, Malakian, Karl, Lockhead, Susan, Olland, Andrea, Svenson, Kristine, Terefenko, Eugene A, Unwalla, Ray J, Wilhelm, James M, Wolfrom, Scott, Zhu, Yuan, Zhang, Zhiming, Zhang, Puwen, Winneker, Richard C, Wrobel, Jay

“…Tanaproget represents a potential first-in-class nonsteroidal PR agonist for contraception with improved safety and side effect profiles versus currently…”
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New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles by Fensome, Andrew, Bender, Reinhold, Cohen, Jeffrey, Collins, Mark A., Mackner, Valerie A., Miller, Lori L., Ullrich, John W., Winneker, Richard, Wrobel, Jay, Zhang, Puwen, Zhang, Zhiming, Zhu, Yuan

“…A new series of 3,3-disubstituted-5-aryloxindoles has been synthesized and evaluated for progesterone receptor antagonist (PR) activity in a T47D cell alkaline…”
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Furan-Terminated N-Acyliminium Ion Initiated Cyclizations in Alkaloid Synthesis by Tanis, Steven P, Deaton, Melissa V, Dixon, Lisa A, McMills, Mark C, Raggon, Jeffrey W, Collins, Mark A

“…A study of the utility of furan-terminated N-acyliminium ion initiated cyclizations for the synthesis of linearly fused alkaloid precursors (Figure ) is…”
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Generating 'omic knowledge': the role of informatics in high content screening by Collins, Mark A

“…High Content Screening (HCS) and High Content Analysis (HCA) have emerged over the past 10 years as a powerful technology for both drug discovery and systems…”
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The HCS data challenge by Collins, Mark A

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Overview of informatics for high content screening by Dunlay, R Terry, Czekalski, Wallace J, Collins, Mark A

“…With the growing use of high content screening (HCS) and analysis in drug discovery and systems biology, informatics has come to the forefront as a critical…”
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Novel pyrrole-containing progesterone receptor modulators by COLLINS, Mark A, HUDAK, Valerie, UNWALLA, Rayomond J, WROBEL, Jay, BENDER, Reinhold, FENSOME, Andrew, PUWEN ZHANG, MILLER, Lori, WINNEKER, Richard C, ZHIMING ZHANG, YUAN ZHU, COHEN, Jeffrey

“…A series of 1,4-dihydro-2H-[d][3,1]-benzoxazin-2-one and 1,3-dihydro-[3H]-indol-2-one containing 6- or 5-, respectively, appended substituted pyrrole moieties…”
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The Effects of Benzodiazepines on Human Opioid Receptor Binding and Function by Cox, Richard F., Collins, Mark A.

“…We performed in vitro studies to investigate the potential interaction of benzodiazepines with cloned human opioid receptor subtypes. Midazolam,…”
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3-(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)- N-alkyl-N-arylbenzamides:  Potent, Non-Peptidic Agonists of Both the μ and δ Opioid Receptors by Bishop, Michael J, Garrido, Dulce M, Boswell, G. Evan, Collins, Mark A, Harris, Philip A, McNutt, Robert W, O'Neill, Scott J, Wei, Ke, Chang, Kwen-Jen

“…Opioid analgesics with both μ and δ opioid receptor activation represent a new approach to the treatment of severe pain with an improved safety profile…”
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Antagonistic modulation between the delta opioid agonist BW373U86 and the mu opioid agonist fentanyl in mice by O'Neill, S J, Collins, M A, Pettit, H O, McNutt, R W, Chang, K J

“…This study was performed to assess the interactions that occur between delta- and mu opioid receptors by studying effects of the systemically active nonpeptide…”
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Phorbol esters induce oscillatory contractions of intestinal smooth muscles by Xu, S F, Collins, M A, Chang, K J

“…The actions of tumor-promoting phorbol esters in smooth muscle excitation-contraction coupling were studied in isolated guinea pig ileum in the presence of…”
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The effects of benzodiazepines on human opioid receptor binding and function by COX, Richard F, COLLINST, Mark A

“…We performed in vitro studies to investigate the potential interaction of benzodiazepines with cloned human opioid receptor subtypes. Midazolam,…”
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3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors by Bishop, Michael J, Garrido, Dulce M, Boswell, G Evan, Collins, Mark A, Harris, Philip A, McNutt, Robert W, O'Neill, Scott J, Wei, Ke, Chang, Kwen-Jen

“…Opioid analgesics with both micro and delta opioid receptor activation represent a new approach to the treatment of severe pain with an improved safety…”
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3-(αR) -α-((2S, 5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl-N-alkyl-N-arylb enzamides: Potent, non-peptidic agonists of both the μ and δ opioid receptors by BISHOP, Michael J, GARRIDO, Dulce M, BOSWELL, G. Evan, COLLINS, Mark A, HARRIS, Philip A, MCNUTT, Robert W, O'NEILL, Scott J, KE WEI, CHANG, Kwen-Jen

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A total synthesis of estradiol and its 6,6-dimethyl analogue by Collins, Mark A., Jones, D.Neville

“…A short, stereoselective synthesis of estradiol, and its 6,6-dimethyl analogue, was accomplished from non-steroidal starting materials. A key feature was the…”
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Efficient synthesis of bicyclo[2.2.1]heptane derivatives via stereoselective intramolecular Michael reactions of vinyl sulfones by Collins, Mark A., Neville Jones, D.

“…Efficient synthesis of 6- endo-methyl substituted bicyclo[ 2.2.1]heptane derivatives formed via completely diastereoselective intramolecular Michael addition…”
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Driving drug discovery and patient therapy via the encapsulation and fusion of knowledge by Collins, M A, Shaw, I, Billington, D C

“…Knowledge and Knowledge Management are becoming common senior management parlance in the Pharmaceutical Industry in the late 1990s. This perspective article…”
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An evaluation of fisherman benefits stemming from special use fishery management by Collins, Mark A

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Managing Toxic Pollutants in Stormwater Runoff by Collins, Mark A., Roller, Ken, Walton, Gail

“…Virginia regulated toxic constituents in storm water overflows through a toxics management programme contained in discharge permits. It required the…”
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