Search Results - "Collins, Lucy M"

REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways by Drouin‐Ouellet, Janelle, Lau, Shong, Brattås, Per Ludvik, Rylander Ottosson, Daniella, Pircs, Karolina, Grassi, Daniela A, Collins, Lucy M, Vuono, Romina, Andersson Sjöland, Annika, Westergren‐Thorsson, Gunilla, Graff, Caroline, Minthon, Lennart, Toresson, Håkan, Barker, Roger A, Jakobsson, Johan, Parmar, Malin

“…Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This…”
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The Genetic Basis of Cognitive Impairment and Dementia in Parkinson's Disease by Collins, Lucy M, Williams-Gray, Caroline H

“…Cognitive dysfunction is a common feature of Parkinson's disease (PD) with mild cognitive impairment affecting around a quarter of patients in the early stages…”
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Dermal fibroblasts from patients with Parkinson’s disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations by Collins, Lucy M, Drouin-Ouellet, Janelle, Kuan, Wei-Li, Cox, Timothy, Barker, Roger A

“…Background: Recently, the development of Parkinson’s disease (PD) has been linked to a number of genetic risk factors, of which the most common is…”
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Impacts of gait freeze on quality of life in Parkinson’s disease, from the perspectives of patients and their carers by Cronin, Padraig, Collins, Lucy M., Sullivan, Aideen M.

“…Background The World Health Organisation (WHO) reports that morbidity and mortality due to Parkinson’s disease (PD) are increasing faster than for other…”
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The motor and cognitive features of Parkinson’s disease in patients with concurrent Gaucher disease over 2 years: a case series by Collins, Lucy M., Williams-Gray, Caroline H., Morris, Elizabeth, Deegan, Patrick, Cox, Timothy M., Barker, Roger A.

“…We report the cognitive features and progression of Parkinson’s disease (PD) in five patients with concurrent Gaucher disease. The patients presented at an…”
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Intensive training programme improves handwriting in a community cohort of people with Parkinson’s disease by Collins, Lucy M., Roberts, Rachel, Cleary, Hannah, Diskin, James, Kitt, Donna, Van Bommel-Rutgers, Ingrid, Smits-Engelsman, Bouwien C. M., Crowley, Erin K., Sullivan, Aideen M.

“…Background People with Parkinson’s disease (PwP) often report problems with their handwriting before they receive a formal diagnosis. Many PwP suffer from…”
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The Addenbrooke’s Cognitive Examination-Revised accurately detects cognitive decline in Huntington’s disease by Begeti, Faye, Tan, Adrian Y. K., Cummins, Gemma A., Collins, Lucy M., Guzman, Natalie Valle, Mason, Sarah L., Barker, Roger A.

“…Cognitive features, which begin before manifestation of the motor features, are an integral part of Huntington’s disease and profoundly affect quality of life…”
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A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease by Collins, Lucy M, Lazic, Stanley E, Barker, Roger A

“…Current clinical assessments of motor function in Huntington's Disease (HD) rely on subjective ratings such as the Unified Huntington's Disease Rating scale…”
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Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease by Collins, Lucy M, Begeti, Faye, Panin, Francesca, Lazar, Alpar S, Cruickshank, Travis, Ziman, Mel, Mason, Sarah L, Barker, Roger A

“…We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor…”
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Dermal fibroblasts from patients with Parkinson's disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations by Collins, Lucy M, Drouin-Ouellet, Janelle, Kuan, Wei-Li, Cox, Timothy, Barker, Roger A

“…Recently, the development of Parkinson's disease (PD) has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA)…”
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