Search Results - "Collins, Kevin M."

Homeostatic Feedback Modulates the Development of Two-State Patterned Activity in a Model Serotonin Motor Circuit in Caenorhabditis elegans by Ravi, Bhavya, Garcia, Jessica, Collins, Kevin M

“…Neuron activity accompanies synapse formation and maintenance, but how early circuit activity contributes to behavior development is not well understood. Here,…”
Get full text

Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition by Collins, Kevin M, Bode, Addys, Fernandez, Robert W, Tanis, Jessica E, Brewer, Jacob C, Creamer, Matthew S, Koelle, Michael R

“…Like many behaviors, egg laying alternates between inactive and active states. To understand how the underlying neural circuit turns the behavior on and off,…”
Get full text

Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior by Banerjee, Navonil, Bhattacharya, Raja, Gorczyca, Michael, Collins, Kevin M, Francis, Michael M

“…Animal behaviors are often composed of distinct alternating behavioral states. Neuromodulatory signals are thought to be critical for establishing stable…”
Get full text

Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p by Stroupe, C, Collins, K.M, Fratti, R.A, Wickner, W

“…Coupling of Rab GTPase activation and SNARE complex assembly during membrane fusion is poorly understood. The homotypic fusion and vacuole protein sorting…”
Get full text

Serotonin and neuropeptides are both released by the HSN command neuron to initiate Caenorhabditis elegans egg laying by Brewer, Jacob C, Olson, Andrew C, Collins, Kevin M, Koelle, Michael R

“…Neurons typically release both a small-molecule neurotransmitter and one or more neuropeptides, but how these two types of signal from the same neuron might…”
Get full text

trans-SNARE complex assembly and yeast vacuole membrane fusion by Collins, Kevin M, Wickner, William T

“…cis-SNARE complexes (anchored in one membrane) are disassembled by Sec17p (α-SNAP) and Sec18p (NSF), permitting the unpaired SNAREs to assemble in trans. We…”
Get full text

Muscle-directed mechanosensory feedback activates egg-laying circuit activity and behavior in Caenorhabditis elegans by Medrano, Emmanuel, Collins, Kevin M.

“…Mechanosensory feedback of the internal reproductive state drives decisions about when and where to reproduce.1 For instance, stretch in the Drosophila…”
Get full text

LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans by Li, Pengpeng, Collins, Kevin M, Koelle, Michael R, Shen, Kang

“…The diverse cell types and the precise synaptic connectivity between them are the cardinal features of the nervous system. Little is known about how cell fate…”
Get full text

Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion by Collins, Kevin M, Thorngren, Naomi L, Fratti, Rutilio A, Wickner, William T

“…SNARE functions during membrane docking and fusion are regulated by Sec1/Munc18 (SM) chaperones and Rab/Ypt GTPase effectors. These functions for yeast vacuole…”
Get full text

Hierarchy of Protein Assembly at the Vertex Ring Domain for Yeast Vacuole Docking and Fusion by Wang, Li, Merz, Alexey J., Collins, Kevin M., Wickner, William

“…Vacuole tethering, docking, and fusion proteins assemble into a "vertex ring" around the apposed membranes of tethered vacuoles before catalyzing fusion…”
Get full text

Serotonin signals through postsynaptic Gαq, Trio RhoGEF, and diacylglycerol to promote Caenorhabditis elegans egg-laying circuit activity and behavior by Dhakal, Pravat, Chaudhry, Sana I, Signorelli, Rossana, Collins, Kevin M

“…Abstract Activated Gαq signals through phospholipase-Cβ and Trio, a Rho GTPase exchange factor (RhoGEF), but how these distinct effector pathways promote…”
Get full text

Serotonin and neuropeptides are both released by the HSN command neuron to initiate C. elegans egg laying by Brewer, Jacob C, Olson, Andrew C, Collins, Kevin M, Koelle, Michael R

“…Neurons typically release both a small-molecule neurotransmitter and one or more neuropeptides, but how these two types of signal from the same neuron might…”
Get full text

Photochemical Barcodes by Tang, Sicheng, Zhang, Yang, Dhakal, Pravat, Ravelo, Laura, Anderson, Cheyenne L, Collins, Kevin M, Raymo, Françisco M

“…A photochemical strategy to encode fluorescence signals in vivo with spatial control was designed around the unique properties of a photoactivatable…”
Get full text

The Sex-Specific VC Neurons Are Mechanically Activated Motor Neurons That Facilitate Serotonin-Induced Egg Laying in C. elegans by Kopchock, 3rd, Richard J, Ravi, Bhavya, Bode, Addys, Collins, Kevin M

“…Successful execution of behavior requires coordinated activity and communication between multiple cell types. Studies using the relatively simple neural…”
Get full text

Postsynaptic ERG potassium channels limit muscle excitability to allow distinct egg-laying behavior states in Caenorhabditis elegans by Collins, Kevin M, Koelle, Michael R

“…Caenorhabditis elegans regulates egg laying by alternating between an inactive phase and a serotonin-triggered active phase. We found that the conserved ERG…”
Get full text

Directed movement changes coexistence outcomes in heterogeneous environments by Zhang, Bo, Lam, King‐Yeung, Ni, Wei‐Ming, Signorelli, Rossana, Collins, Kevin M., Fu, Zhiyuan, Zhai, Lu, Lou, Yuan, DeAngelis, Donald L., Hastings, Alan, Chase, Jonathan

“…Understanding mechanisms of coexistence is a central topic in ecology. Mathematical analysis of models of competition between two identical species moving at…”
Get full text

Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans by Ravi, Bhavya, Zhao, Jian, Chaudhry, Sana I, Signorelli, Rossana, Bartole, Mattingly, Kopchock, Richard J, Guijarro, Christian, Kaplan, Joshua M, Kang, Lijun, Collins, Kevin M

“…Abstract Egg laying in the nematode worm Caenorhabditis elegans is a two-state behavior modulated by internal and external sensory input. We have previously…”
Get full text

Bioimaging with Macromolecular Probes Incorporating Multiple BODIPY Fluorophores by Thapaliya, Ek Raj, Zhang, Yang, Dhakal, Pravat, Brown, Adrienne S, Wilson, James N, Collins, Kevin M, Raymo, Françisco M

“…Seven macromolecular constructs incorporating multiple borondipyrromethene (BODIPY) fluorophores along a common poly­(methacrylate) backbone with decyl and…”
Get full text

Ratiometric Calcium Imaging of Individual Neurons in Behaving Caenorhabditis Elegans by Ravi, Bhavya, Nassar, Layla M, Kopchock, 3rd, Richard J, Dhakal, Pravat, Scheetz, Michael, Collins, Kevin M

“…It has become increasingly clear that neural circuit activity in behaving animals differs substantially from that seen in anesthetized or immobilized animals…”
Get full text

Stringent 3Q·1R Composition of the SNARE 0-Layer Can Be Bypassed for Fusion by Compensatory SNARE Mutation or by Lipid Bilayer Modification by Fratti, Rutilio A., Collins, Kevin M., Hickey, Christopher M., Wickner, William

“…SNARE proteins form bundles of four α-helical SNARE domains with conserved polar amino acids, 3Q and 1R, at the “0-layer” of the bundle. Previous studies have…”
Get full text