Search Results - "Collins, Keagan P."

Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics by Ramirez, Dominique A, Collins, Keagan P, Aradi, Allister E, Conger, Katherine A, Gustafson, Daniel L

“…Cyclophosphamide (CP), a prodrug that is enzymatically converted to the cytotoxic 4-hydroxycyclophosphamide (4OHCP) by hepatic enzymes, is commonly used in…”
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Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism by Witta, Sandra, Collins, Keagan P., Ramirez, Dominique A., Mannheimer, Joshua D., Wittenburg, Luke A., Gustafson, Daniel L.

“…Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic…”
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Genomics Analysis of L-DOPA Exposure in Drosophila sechellia by Lanno, Stephen M, Lam, Ivy, Drum, Zachary, Linde, Samuel C, Gregory, Sara M, Shimshak, Serena J, Becker, Mariel V, Brew, Kerry E, Budhiraja, Aashli, Carter, Eliza A, Chigweshe, Lorencia, Collins, Keagan P, Earley, Timothy, Einstein, Hannah L, Fan, Angela A, Goss, Sarah S, Hagen, Eric R, Hutcheon, Sarah B, Kim, Timothy T, Mitchell, Mackenzie A, Neri, Nola R, Patterson, Sean E, Ransom, Gregory, Sanchez, Guadalupe J, Wiener, Bella M, Zhao, Dacheng, Coolon, Joseph D

“…is a dietary specialist fruit fly that evolved from a generalist ancestor to specialize on the toxic fruit of This species pair has been the subject of…”
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Lysosomal Biogenesis and Implications for Hydroxychloroquine Disposition by Collins, Keagan P, Witta, Sandra, Coy, Jonathan W, Pang, Yi, Gustafson, Daniel L

“…Lysosomes act as a cellular drug sink for weakly basic, lipophilic (lysosomotropic) xenobiotics, with many instances of lysosomal trapping associated with…”
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Prospective clinical trial testing COXEN-based gene expression models of chemosensitivity in dogs with spontaneous osteosarcoma by Gustafson, Daniel L., Collins, Keagan P., Fowles, Jared S., Ehrhart, E. J., Weishaar, Kristen M., Das, Sunetra, Duval, Dawn L., Thamm, Douglas H.

“…Background This study is a prospective clinical trial in dogs with osteosarcoma testing a gene expression model (GEM) predicting the chemosensitivity of tumors…”
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Vinca Alkaloid Pharmacokinetics in the Context of a Physiologically‐Based Murine Model by Collins, Keagan P., Mannheimer, Joshua D., Gustafson, Daniel L.

“…Vinca alkaloids are a class of molecule clinically used as cytotoxic chemotherapeutics, and exert their activity through mitotic disruption by preventing the…”
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Abstract 1503: A physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine by Collins, Keagan P., Jackson, Kristen M., Gustafson, Daniel L.

“…Hydroxychloroquine (HCQ) is a lysotropic autophagy inhibitor that is being used in over 45 clinical trials either alone or in combination with another…”
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A Pharmacokinetic Investigation of Chloroquine Analogues in Cancer Autophagy Modulation by Collins, Keagan P

“…Hydroxychloroquine (HCQ) is currently being investigated for safety and efficacy as an autophagy inhibitor in Phase I/II cancer clinical trials. It is the only…”
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