Search Results - "Collins, Jon"

Ube3a unsilencer for the potential treatment of Angelman syndrome by Vihma, Hanna, Li, Kelin, Welton-Arndt, Anna, Smith, Audrey L., Bettadapur, Kiran R., Gilmore, Rachel B., Gao, Eric, Cotney, Justin L., Huang, Hsueh-Cheng, Collins, Jon L., Chamberlain, Stormy J., Lee, Hyeong-Min, Aubé, Jeffrey, Philpot, Benjamin D.

“…Deletion of the maternal UBE3A allele causes Angelman syndrome (AS) ; because paternal UBE3A is epigenetically silenced by a long non-coding antisense (…”
Get full text

ApoE Promotes the Proteolytic Degradation of Aβ by Jiang, Qingguang, Lee, C.Y. Daniel, Mandrekar, Shweta, Wilkinson, Brandy, Cramer, Paige, Zelcer, Noam, Mann, Karen, Lamb, Bruce, Willson, Timothy M., Collins, Jon L., Richardson, Jill C., Smith, Jonathan D., Comery, Thomas A., Riddell, David, Holtzman, David M., Tontonoz, Peter, Landreth, Gary E.

“…Apolipoprotein E is associated with age-related risk for Alzheimer's disease and plays critical roles in Aβ homeostasis. We report that ApoE plays a role in…”
Get full text

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120) by Sparks, Steven M., Chen, Grace, Collins, Jon L., Danger, Dana, Dock, Steven T., Jayawickreme, Channa, Jenkinson, Stephen, Laudeman, Christopher, Leesnitzer, M. Anthony, Liang, Xi, Maloney, Patrick, McCoy, David C., Moncol, David, Rash, Vincent, Rimele, Thomas, Vulimiri, Padmaja, Way, James M., Ross, Sean

“…The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of…”
Get full text

Recruitment of FBXO22 for targeted degradation of NSD2 by Nie, David Y, Tabor, John R, Li, Jianping, Kutera, Maria, St-Germain, Jonathan, Hanley, Ronan P, Wolf, Esther, Paulakonis, Ethan, Kenney, Tristan M G, Duan, Shili, Shrestha, Suman, Owens, Dominic D G, Maitland, Matthew E R, Pon, Ailing, Szewczyk, Magdalena, Lamberto, Anthony Joseph, Menes, Michael, Li, Fengling, Penn, Linda Z, Barsyte-Lovejoy, Dalia, Brown, Nicholas G, Barsotti, Anthony M, Stamford, Andrew W, Collins, Jon L, Wilson, Derek J, Raught, Brian, Licht, Jonathan D, James, Lindsey I, Arrowsmith, Cheryl H

“…Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of…”
Get full text

The Nuclear Receptor Superfamily and Drug Discovery by Moore, John T., Collins, Jon L., Pearce, Kenneth H.

“…Targeting the nuclear receptors: The ligand‐binding domain of the glucocorticoid receptor (ribbon) bound with the ligand, dexamethasone (space‐filling) is just…”
Get full text

Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes by Chen, Lihong, Yao, Xiaozhou, Young, Andrew, McNulty, Judi, Anderson, Don, Liu, Yaping, Nystrom, Christopher, Croom, Dallas, Ross, Sean, Collins, Jon, Rajpal, Deepak, Hamlet, Kimberly, Smith, Chari, Gedulin, Bronislava

“…Bile acids are recognized as metabolic modulators. The present study was aimed at evaluating the effects of a potent Asbt inhibitor (264W94), which blocks…”
Get more information

Population pharmacokinetics of belantamab mafodotin, a BCMA‐targeting agent in patients with relapsed/refractory multiple myeloma by Rathi, Chetan, Collins, Jon, Struemper, Herbert, Opalinska, Joanna, Jewell, Roxanne C., Ferron‐Brady, Geraldine

“…Belantamab mafodotin (belamaf) is an antibody–drug conjugate (ADC) targeting B‐cell maturation antigen (BCMA). Nonlinear mixed‐effects models were developed to…”
Get full text

Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors by Joseph, Sean B., Laffitte, Bryan A., Patel, Parthive H., Watson, Michael A., Matsukuma, Karen E., Walczak, Robert, Collins, Jon L., Osborne, Timothy F., Tontonoz, Peter

“…The nuclear receptors LXRα and LXRβ have been implicated in the control of lipogenesis and cholesterol homeostasis. Ligand activation of these receptors in…”
Get full text

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE by Bradley, Michelle N, Hong, Cynthia, Chen, Mingyi, Joseph, Sean B, Wilpitz, Damien C, Wang, Xuping, Lusis, Aldons J, Collins, Allan, Hseuh, Willa A, Collins, Jon L, Tangirala, Rajendra K, Tontonoz, Peter

“…Liver X receptors (LXRs) alpha and beta are transcriptional regulators of cholesterol homeostasis and potential targets for the development of…”
Get full text

Divalproex, lithium and suicide among Medicaid patients with bipolar disorder by Collins, Jon C, McFarland, Bentson H

“…Abstract Background Suicide completion and attempted suicide are major concerns for people with bipolar disorder. Studies in the private sector have suggested…”
Get full text

Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice by Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., Chen, Mingyi, Noh, Grace, Goodman, Joanne, Hagger, Graham N., Tran, Jonathan, Tippin, Tim K., Wang, Xuping, Lusis, Aldons J., Hsueh, Willa A., Law, Ronald E., Collins, Jon L., Willson, Timothy M., Tontonoz, Peter

“…The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these…”
Get full text

Activation of Liver X Receptor Improves Glucose Tolerance through Coordinate Regulation of Glucose Metabolism in Liver and Adipose Tissue by Laffitte, Bryan A., Chao, Lily C., Li, Jing, Walczak, Robert, Hummasti, Sarah, Joseph, Sean B., Castrillo, Antonio, Wilpitz, Damien C., Mangelsdorf, David J., Collins, Jon L., Saez, Enrique, Tontonoz, Peter

“…The control of lipid and glucose metabolism is closely linked. The nuclear receptors liver X receptor (LXR)α and LXRβ have been implicated in gene expression…”
Get full text

GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα by Grant, Daniel, Yin, Lei, Collins, Jon L, Parks, Derek J, Orband-Miller, Lisa A, Wisely, G. Bruce, Joshi, Shree, Lazar, Mitchell A, Willson, Timothy M, Zuercher, William J

“…The identification of nonporphyrin ligands for the orphan nuclear receptor Rev-erbα will enable studies of its role as a heme sensor and regulator of metabolic…”
Get full text

Longitudinal efficacy and safety modeling and simulation framework to aid dose selection of belantamab mafodotin for patients with multiple myeloma by Collins, Jon, van Noort, Martijn, Rathi, Chetan, Post, Teun M, Struemper, Herbert, Jewell, Roxanne C, Ferron-Brady, Geraldine

“…Belantamab mafodotin, a monomethyl auristatin F (MMAF)-containing monoclonal antibody-drug conjugate (ADC), demonstrated deep and durable responses in the…”
Get full text

Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes by Maglich, Jodi M., Parks, Derek J., Moore, Linda B., Collins, Jon L., Goodwin, Bryan, Billin, Andrew N., Stoltz, Catherine A., Kliewer, Steven A., Lambert, Millard H., Willson, Timothy M., Moore, John T.

“…The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central role in the response to xenochemical stress. Identification of CAR…”
Get full text

Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist by Sparks, Steven M., Aquino, Christopher, Banker, Pierette, Collins, Jon L., Cowan, David, Diaz, Caroline, Dock, Steven T., Hertzog, Donald L., Liang, Xi, Swiger, Erin D., Yuen, Josephine, Chen, Grace, Jayawickreme, Channa, Moncol, David, Nystrom, Christopher, Rash, Vincent, Rimele, Thomas, Roller, Shane, Ross, Sean

“…[Display omitted] The long chain free fatty acid receptor 4 (FFA4/GPR120) has recently been recognized as lipid sensor playing important roles in nutrient…”
Get full text

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism by Xue, Yu, Chao, Esther, Zuercher, William J., Willson, Timothy M., Collins, Jon L., Redinbo, Matthew R.

“…The crystal structure of the nuclear xenobiotic receptor PXR in complex with T0901317 leads to the synthesis of agonists specific to PXR relative to the…”
Get full text

Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists by Zuercher, William J, Buckholz, Richard G, Campobasso, Nino, Collins, Jon L, Galardi, Cristin M, Gampe, Robert T, Hyatt, Stephen M, Merrihew, Susan L, Moore, John T, Oplinger, Jeffrey A, Reid, Paul R, Spearing, Paul K, Stanley, Thomas B, Stewart, Eugene L, Willson, Timothy M

“…Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased…”
Get full text

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity by Watkins, Ryan E., Wisely, G. Bruce, Moore, Linda B., Collins, Jon L., Lambert, Millard H., Williams, Shawn P., Willson, Timothy M., Kliewer, Steven A., Redinbo, Matthew R.

“…The human nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in…”
Get full text

Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin by Chrencik, Jill E, Orans, Jillian, Moore, Linda B, Xue, Yu, Peng, Li, Collins, Jon L, Wisely, G. Bruce, Lambert, Millard H, Kliewer, Steven A, Redinbo, Matthew R

“…The human nuclear xenobiotic receptor, pregnane X receptor (PXR), detects a variety of structurally distinct endogenous and xenobiotic compounds and controls…”
Get full text