Search Results - "Collingwood, Joanna F"

Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects by Everett, James, Collingwood, Joanna F, Tjendana-Tjhin, Vindy, Brooks, Jake, Lermyte, Frederik, Plascencia-Villa, Germán, Hands-Portman, Ian, Dobson, Jon, Perry, George, Telling, Neil D

“…Altered metabolism of biometals in the brain is a key feature of Alzheimer's disease, and biometal interactions with amyloid-β are linked to amyloid plaque…”
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High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease by Plascencia-Villa, Germán, Ponce, Arturo, Collingwood, Joanna F., Arellano-Jiménez, M. Josefina, Zhu, Xiongwei, Rogers, Jack T., Betancourt, Israel, José-Yacamán, Miguel, Perry, George

“…Abnormal accumulation of brain metals is a key feature of Alzheimer’s disease (AD). Formation of amyloid-β plaque cores (APC) is related to interactions with…”
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Magnetoresponsive liposomes applications in nanomedicine: A comprehensive review by Shahsavari, Shayan, Rad, Mohammad Behnam, Hajiaghajani, Amirhossein, Rostami, Mohammadreza, Hakimian, Fatemeh, Jafarzadeh, Sina, Hasany, Masoud, Collingwood, Joanna F., Aliakbari, Farhang, Fouladiha, Hamideh, Bardania, Hassan, Otzen, Daniel E., Morshedi, Dina

“…Safe and effective cancer therapy requires a suitable nanocarrier that can target particular sites, such as cancer cells, in a selective manner. With the…”
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Multiple Protective Roles of Nanoliposome‐Incorporated Baicalein against Alpha‐Synuclein Aggregates by Aliakbari, Farhang, Mohammad‐Beigi, Hossein, Abbasi, Shahsanam, Rezaei‐Ghaleh, Nasrollah, Lermyte, Frederik, Parsafar, Soha, Becker, Stefan, Tafreshi, Azita Parvaneh, O'Connor, Peter B., Collingwood, Joanna F., Christiansen, Gunna, Sutherland, Duncan S., Jensen, Poul Henning, Morshedi, Dina, Otzen, Daniel E.

“…Nanoparticles are useful for increasing drug stability, solubility, and availability. The small molecule baicalein inhibits fibrillation, and detoxifies…”
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A Systematic Review and Meta-Analysis of Cerebrospinal Fluid Amyloid and Tau Levels Identifies Mild Cognitive Impairment Patients Progressing to Alzheimer's Disease by Ma, Yunxing, Brettschneider, Julia, Collingwood, Joanna F

“…Reported levels of amyloid-beta and tau in human cerebrospinal fluid (CSF) were evaluated to discover if these biochemical markers can predict the transition…”
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Biogenic metallic elements in the human brain? by Everett, James, Lermyte, Frederik, Brooks, Jake, Tjendana-Tjhin, Vindy, Plascencia-Villa, Germán, Hands-Portman, Ian, Donnelly, Jane M, Billimoria, Kharmen, Perry, George, Zhu, Xiongwei, Sadler, Peter J, O'Connor, Peter B, Collingwood, Joanna F, Telling, Neil D

“…The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu , Cu , Fe ,…”
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Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra by Brooks, Jake, Everett, James, Hill, Emily, Billimoria, Kharmen, Morris, Christopher M., Sadler, Peter J., Telling, Neil, Collingwood, Joanna F.

“…Neuromelanin-pigmented neurons of the substantia nigra are selectively lost during the progression of Parkinson’s disease. These neurons accumulate iron in the…”
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Gene co-expression networks shed light into diseases of brain iron accumulation by Bettencourt, Conceição, Forabosco, Paola, Wiethoff, Sarah, Heidari, Moones, Johnstone, Daniel M, Botía, Juan A, Collingwood, Joanna F, Hardy, John, Milward, Elizabeth A, Ryten, Mina, Houlden, Henry

“…Abstract Aberrant brain iron deposition is observed in both common and rare neurodegenerative disorders, including those categorized as Neurodegeneration with…”
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Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies by Lermyte, Frederik, Everett, James, Brooks, Jake, Bellingeri, Francesca, Billimoria, Kharmen, Sadler, Peter J, O'Connor, Peter B, Telling, Neil D, Collingwood, Joanna F

“…Transition metals have essential roles in brain structure and function, and are associated with pathological processes in neurodegenerative disorders classed…”
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Impact of Autophagy and Aging on Iron Load and Ferritin in Drosophila Brain by Jacomin, Anne-Claire, Geraki, Kalotina, Brooks, Jake, Tjendana-Tjhin, Vindy, Collingwood, Joanna F, Nezis, Ioannis P

“…Biometals such as iron, copper, potassium, and zinc are essential regulatory elements of several biological processes. The homeostasis of biometals is often…”
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Effective R2 relaxation rate, derived from dual-contrast fast-spin-echo MRI, enables detection of hemisphere differences in iron level and dopamine function in Parkinson’s disease and healthy individuals by Luo, Jierong, Collingwood, Joanna F.

“…Clinical estimates of brain iron concentration are achievable with quantitative transverse relaxation rate R2, via time-consuming multiple spin-echo (SE)…”
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Chemical imaging analysis of the brain with X-ray methods by Collingwood, Joanna F, Adams, Freddy

“…Cells employ various metal and metalloid ions to augment the structure and the function of proteins and to assist with vital biological processes. In the brain…”
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Regional segmentation strategy for DTI analysis of human corpus callosum indicates motor function deficit in mild cognitive impairment by Rajan, Surya, Brettschneider, Julia, Collingwood, Joanna F.

“…[Display omitted] •Linear regression model of DTI properties of the corpus callosum in healthy ageing.•Corpus callosum segmentation strategy increases…”
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Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease by Telling, Neil D, Everett, James, Collingwood, Joanna F, Dobson, Jon, van der Laan, Gerrit, Gallagher, Joseph J, Wang, Jian, Hitchcock, Adam P

“…A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aβ) fibrils in the brain. Nevertheless, the links between Aβ and AD…”
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Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ(1-42) by Everett, James, Brooks, Jake, Lermyte, Frederik, O’Connor, Peter B., Sadler, Peter J., Dobson, Jon, Collingwood, Joanna F., Telling, Neil D.

“…Atypical low-oxidation-state iron phases in Alzheimer’s disease (AD) pathology are implicated in disease pathogenesis, as they may promote elevated redox…”
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Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry by Lermyte, Frederik, Everett, James, Lam, Yuko P. Y., Wootton, Christopher A., Brooks, Jake, Barrow, Mark P., Telling, Neil D., Sadler, Peter J., O’Connor, Peter B., Collingwood, Joanna F.

“…Native top-down mass spectrometry is a fast, robust biophysical technique that can provide molecular-scale information on the interaction between proteins or…”
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Label‐Free Nanoimaging of Neuromelanin in the Brain by Soft X‐ray Spectromicroscopy by Brooks, Jake, Everett, James, Lermyte, Frederik, Tjhin, Vindy Tjendana, Banerjee, Samya, O'Connor, Peter B., Morris, Christopher M., Sadler, Peter J., Telling, Neil D., Collingwood, Joanna F.

“…A hallmark of Parkinson's disease is the death of neuromelanin‐pigmented neurons, but the role of neuromelanin is unclear. The in situ characterization of…”
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Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy by Brooks, Jake, Everett, James, Lermyte, Frederik, Tjendana Tjhin, Vindy, Sadler, Peter J., Telling, Neil, Collingwood, Joanna F.

“…•Soft x-ray spectromicroscopy analysis of Parkinson’s disease substantia nigra.•Label-free characterisation of organic and inorganic tissue components.•Mixed…”
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The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease by Aliakbari, Farhang, Mohammad-Beigi, Hossein, Rezaei-Ghaleh, Nasrollah, Becker, Stefan, Dehghani Esmatabad, Faezeh, Eslampanah Seyedi, Hadieh Alsadat, Bardania, Hassan, Tayaranian Marvian, Amir, Collingwood, Joanna F, Christiansen, Gunna, Zweckstetter, Markus, Otzen, Daniel E, Morshedi, Dina

“…The protein α-synuclein (αSN) aggregates to form fibrils in neuronal cells of Parkinson's patients. Here we report on the effect of neutral (zwitterionic)…”
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Synchrotron XRF imaging of Alzheimer’s disease basal ganglia reveals linear dependence of high-field magnetic resonance microscopy on tissue iron concentration by Finnegan, Mary E., Visanji, Naomi P., Romero-Canelon, Isolda, House, Emily, Rajan, Surya, Mosselmans, J. Frederick W., Hazrati, Lili-Naz, Dobson, Jon, Collingwood, Joanna F.

“…[Display omitted] •Quantified impact of tissue iron levels on high field magnetic resonance imaging.•Validation with post-mortem synchrotron X-ray imaging of…”
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