Search Results - "Collier, RJohn"

Anthrax toxin: receptor binding, internalization, pore formation, and translocation by Young, John A T, Collier, R John

“…Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-bearing mammalian cells or in solution, yielding a series of…”
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Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen by McCluskey, Andrew J., Olive, Andrew J., Starnbach, Michael N., Collier, R. John

“…Targeted therapeutics have emerged in recent years as an attractive approach to treating various types of cancer. One approach is to modify a cytocidal protein…”
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Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen by Dmochewitz, Lydia, Lillich, Maren, Kaiser, Eva, Jennings, Laura D, Lang, Alexander E, Buchner, Johannes, Fischer, Gunter, Aktories, Klaus, Collier, R. John, Barth, Holger

“…Bacillus anthracis lethal toxin consists of the protective antigen (PA) and the metalloprotease lethal factor (LF). During cellular uptake PA forms pores in…”
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A Phenylalanine Clamp Catalyzes Protein Translocation through the Anthrax Toxin Pore by Krantz, Bryan A., Melnyk, Roman A., Zhang, Sen, Juris, Stephen J., Lacy, D. Borden, Wu, Zhengyan, Finkelstein, Alan, Collier, R. John

“…The protective antigen component of anthrax toxin forms a homoheptameric pore in the endosomal membrane, creating a narrow passageway for the enzymatic…”
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Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras by Zornetta, Irene, Brandi, Lucia, Janowiak, Blythe, Dal Molin, Federica, Tonello, Fiorella, Collier, R. John, Montecucco, Cesare

“…To investigate the cell entry and intracellular trafficking of anthrax oedema factor (EF) and lethal factor (LF), they were C-terminally fused to the enhanced…”
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Conformational Switching of the Diphtheria Toxin T Domain by Rodnin, Mykola V., Kyrychenko, Alexander, Kienker, Paul, Sharma, Onkar, Posokhov, Yevgen O., Collier, R. John, Finkelstein, Alan, Ladokhin, Alexey S.

“…The diphtheria toxin T domain translocates the catalytic C domain across the endosomal membrane in response to acidification. To elucidate the role of…”
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Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers by Fischer, Audrey, Holden, Matthew A, Pentelute, Brad L, Collier, R. John

“…Many bacterial toxins form proteinaceous pores that facilitate the translocation of soluble effector proteins across cellular membranes. With anthrax toxin…”
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Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation by Sun, Jianjun, Lang, Alexander E, Aktories, Klaus, Collier, R. John

“…The protective antigen (PA) moiety of anthrax toxin forms a heptameric pore in endosomal membranes of mammalian cells and translocates the enzymatic moieties…”
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Structure of Heptameric Protective Antigen Bound to an Anthrax Toxin Receptor: A Role for Receptor in pH-Dependent Pore Formation by Lacy, D. Borden, Wigelsworth, Darran J., Melnyk, Roman A., Harrison, Stephen C., Collier, R. John

“…After binding to cellular receptors and proteolytic activation, the protective antigen component of anthrax toxin forms a heptameric prepore. The prepore later…”
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Evidence That Translocation of Anthrax Toxin's Lethal Factor Is Initiated by Entry of Its N Terminus into the Protective Antigen Channel by Zhang, Sen, Finkelstein, Alan, Collier, R. John, Karlin, Arthur

“…Entry of the enzymatic components of anthrax toxin [lethal factor (LF) and edema factor] into the cytosol of mammalian cells depends on the ability of the…”
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A Loop Network within the Anthrax Toxin Pore Positions the Phenylalanine Clamp in an Active Conformation by Melnyk, Roman A., Collier, R. John

“…Heptameric pores formed in the endosomal membrane by the protective antigen moiety of anthrax toxin serve as portals for entry of the enzymatic moieties of the…”
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Salmonella's Safety Catch by Collier, R. John

“…Many pathogenic bacteria disable their host's immune system and thereby protect themselves from destruction by delivering "effector proteins" into the inner,…”
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Insertion of Anthrax Protective Antigen into Liposomal Membranes: EFFECTS OF A RECEPTOR by Sun, Jianjun, Vernier, Gregory, Wigelsworth, Darran J, Collier, R. John

“…Protective antigen (PA), the receptor-binding component of anthrax toxin, heptamerizes and inserts into the endosomal membrane at acidic pH, forming a pore…”
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Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus by Kim, Chun, Wilcox-Adelman, Sarah, Sano, Yasuyo, Tang, Wei-Jen, Collier, R. John, Park, Jin Mo

“…Bacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we…”
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Receptor-Specific Requirements for Anthrax Toxin Delivery into Cells by G. Jonah A. Rainey, Wigelsworth, Darran J., Ryan, Patricia L., Scobie, Heather M., Collier, R. John, John A. T. Young

“…The three proteins that constitute anthrax toxin self-assemble into toxic complexes after one of these proteins, protective antigen (PA), binds to tumor…”
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Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature by Bolcome, Robert E. III, Sullivan, Sarah E, Zeller, René, Barker, Adam P, Collier, R. John, Chan, Joanne

“…Vascular dysfunction has been reported in human cases of anthrax, in mammalian models of Bacillus anthracis, and in animals injected with anthrax toxin…”
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Evidence for a ProtonaProtein Symport Mechanism in the Anthrax Toxin Channel by Basilio, Daniel, Juris, Stephen J, Collier, RJohn, Finkelstein, Alan

“…The toxin produced by Bacillus anthracis, the causative agent of anthrax, is composed of three proteins: a translocase heptameric channel, (PA sub(63)) sub(7),…”
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Monoclonal Antibody to Bacillus anthracis Protective Antigen Defines a Neutralizing Epitope in Domain 1 by Rivera, Johanna, Nakouzi, Antonio, Abboud, Nareen, Revskaya, Ekaterina, Goldman, David, Collier, R. John, Dadachova, Ekaterina, Casadevall, Arturo

“…Antibody (Ab) responses to Bacillus anthracis toxins are protective, but relatively few protective monoclonal antibodies (MAbs) have been reported. Protective…”
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Crystal structure of the zeta isoform of the 14-3-3 protein by Liu, Dong, Bienkowska, Jadwiga, Petosa, Carlo, Collier, R. John, Fu, Halan, Liddington, Robert

“…The 14-3-3 family of proteins have recently been identified as regulatory elements in intracellular signalling pathways: 14-3-3 proteins bind to oncogene and…”
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Mutant anthrax toxin B moiety (Protective Antigen) inhibits angiogenesis and tumor growth by ROGERS, Michael S, CHRISTENSEN, Kenneth A, BIRSNER, Amy E, SHORT, Sarah M, WIGELSWORTH, Darran J, COLLIER, R. John, D'AMATO, Robert J

“…Bacillus anthracis protective antigen (PA), the B subunit of the binary anthrax toxin, binds to the cellular receptors capillary morphogenesis gene 2 protein…”
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