Search Results - "Collie, Iain T"

Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase by Read, Jon, Collie, Iain T., Nguyen-McCarty, Michelle, Lucaj, Christopher, Robinson, James, Conway, Leslie, Mukherjee, Jayanta, McCall, Eileen, Donohoe, Gerard, Flavell, Elizabeth, Peciak, Karolina, Warwicker, Juli, Dix, Carly, Van den Hoven, Bernard G., Madin, Andrew, Brown, Dean G., Moss, Stephen, Haggarty, Stephen J., Brandon, Nicholas J., Bürli, Roland W.

“…[Display omitted] The TRAF2 and NCK interacting kinase (TNIK) has been proposed to play a role in cytoskeletal organization and synaptic plasticity and has…”
Get full text

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening by Mpamhanga, Chidochangu P, Spinks, Daniel, Tulloch, Lindsay B, Shanks, Emma J, Robinson, David A, Collie, Iain T, Fairlamb, Alan H, Wyatt, Paul G, Frearson, Julie A, Hunter, William N, Gilbert, Ian H, Brenk, Ruth

“…The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual screening campaign for…”
Get full text

Development of a Series of Pyrrolopyridone MAT2A Inhibitors by Atkinson, Stephen J., Bagal, Sharan K., Argyrou, Argyrides, Askin, Sean, Cheung, Tony, Chiarparin, Elisabetta, Coen, Muireann, Collie, Iain T., Dale, Ian L., De Fusco, Claudia, Dillman, Keith, Evans, Laura, Feron, Lyman J., Foster, Alison J., Grondine, Michael, Kantae, Vasudev, Lamont, Gillian M., Lamont, Scott, Lynch, James T., Nilsson Lill, Sten, Robb, Graeme R., Saeh, Jamal, Schimpl, Marianne, Scott, James S., Smith, James, Srinivasan, Bharath, Tentarelli, Sharon, Vazquez-Chantada, Mercedes, Wagner, David, Walsh, Jarrod J., Watson, David, Williamson, Beth

“…The optimization of an allosteric fragment, discovered by differential scanning fluorimetry, to an in vivo MAT2a tool inhibitor is discussed. The…”
Get full text

HTS and hit finding in academia – from chemical genomics to drug discovery by Frearson, Julie A., Collie, Iain T.

“…The liaison between academia and the pharmaceutical industry was originally served primarily through the scientific literature and limited, specific…”
Get full text

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues by Cleghorn, Laura A. T., Wall, Richard J., Albrecht, Sébastien, MacGowan, Stuart A., Norval, Suzanne, De Rycker, Manu, Woodland, Andrew, Spinks, Daniel, Thompson, Stephen, Patterson, Stephen, Corpas Lopez, Victoriano, Dey, Gourav, Collie, Iain T., Hallyburton, Irene, Kime, Robert, Simeons, Frederick R. C., Stojanovski, Laste, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Wyllie, Susan

“…While treatment options for human African trypanosomiasis (HAT) have improved significantly, there is still a need for new drugs with eradication now a…”
Get full text

The First Potent and Selective Inhibitors of the Glycine Transporter Type 2 by Caulfield, Wilson L, Collie, Iain T, Dickins, Rachel S, Epemolu, Ola, McGuire, Ross, Hill, David R, McVey, Gillian, Morphy, J. Richard, Rankovic, Zoran, Sundaram, Hardy

Get full text

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei by Cleghorn, Laura A. T., Albrecht, Sébastien, Stojanovski, Laste, Simeons, Frederick R. J., Norval, Suzanne, Kime, Robert, Collie, Iain T., De Rycker, Manu, Campbell, Lorna, Hallyburton, Irene, Frearson, Julie A., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.

“…There is an urgent need for new, brain penetrant small molecules that target the central nervous system second stage of human African trypanosomiasis (HAT). We…”
Get full text

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode by Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A., Luksch, Torsten, Smith, Alasdair, Torrie, Leah S., McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T., Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.

“…The enzyme N‐myristoyltransferase (NMT) from Trypanosoma brucei has been validated both chemically and biologically as a potential drug target for human…”
Get full text

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3 by Cleghorn, Laura A. T., Woodland, Andrew, Collie, Iain T., Torrie, Leah S., Norcross, Neil, Luksch, Torsten, Mpamhanga, Chido, Walker, Roderick G., Mottram, Jeremy C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.

“…New drugs are urgently needed for the treatment of tropical parasitic diseases such as leishmaniasis and human African trypanosomiasis (HAT). This work…”
Get full text

A Novel Allosteric Inhibitor of the Uridine Diphosphate N‑Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei by Urbaniak, Michael D, Collie, Iain T, Fang, Wenxia, Aristotelous, Tonia, Eskilsson, Susanne, Raimi, Olawale G, Harrison, Justin, Navratilova, Iva Hopkins, Frearson, Julie A, van Aalten, Daan M. F, Ferguson, Michael A. J

“…Uridine diphosphate N-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final reaction in the biosynthesis of UDP-GlcNAc, an essential metabolite in many…”
Get full text

Quinol derivatives as potential trypanocidal agents by Capes, Amy, Patterson, Stephen, Wyllie, Susan, Hallyburton, Irene, Collie, Iain T., McCarroll, Andrew J., Stevens, Malcolm F.G., Frearson, Julie A., Wyatt, Paul G., Fairlamb, Alan H., Gilbert, Ian H.

“…Quinols have been developed as a class of potential anti-cancer compounds. They are thought to act as double Michael acceptors, forming two covalent bonds to…”
Get full text

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 by Spinks, Daniel, Ong, Han B., Mpamhanga, Chidochangu P., Shanks, Emma J., Robinson, David A., Collie, Iain T., Read, Kevin D., Frearson, Julie A., Wyatt, Paul G., Brenk, Ruth, Fairlamb, Alan H., Gilbert, Ian H.

“…Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite Trypanosoma brucei. Herein, we…”
Get full text

Cover Picture: Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015) by Spinks, Daniel, Smith, Victoria, Thompson, Stephen, Robinson, David A., Luksch, Torsten, Smith, Alasdair, Torrie, Leah S., McElroy, Stuart, Stojanovski, Laste, Norval, Suzanne, Collie, Iain T., Hallyburton, Irene, Rao, Bhavya, Brand, Stephen, Brenk, Ruth, Frearson, Julie A., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.

“…The front cover picture shows the enzyme N‐myristoyltransferase from the pathogen Trypanosoma brucei. Next to this is an image of the parasite. Also shown are…”
Get full text

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488 by Smith, Victoria C., Cleghorn, Laura A. T., Woodland, Andrew, Spinks, Daniel, Hallyburton, Irene, Collie, Iain T., Yi Mok, N., Norval, Suzanne, Brenk, Ruth, Fairlamb, Alan H., Frearson, Julie A., Read, Kevin D., Gilbert, Ian H., Wyatt, Paul G.

“…Screening of the Sigma–Aldrich Library of Pharmacologically Active Compounds (LOPAC) against cultured Trypanosoma brucei, the causative agent of African…”
Get full text

Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011) by Walton, Jeffrey G. A., Jones, Deuan C., Kiuru, Paula, Durie, Alastair J., Westwood, Nicholas J., Fairlamb, Alan H., Spinks, Daniel, Ong, Han B., Mpamhanga, Chidochangu P., Shanks, Emma J., Robinson, David A., Collie, Iain T., Read, Kevin D., Frearson, Julie A., Wyatt, Paul G., Brenk, Ruth, Fairlamb, Alan H., Gilbert, Ian H., Ruda, Gian Filippo, Nguyen, Corinne, Ziemkowski, Przemysław, Felczak, Krzysztof, Kasinathan, Ganasan, Musso-Buendia, Alexander, Sund, Christian, Zhou, Xiao Xiong, Kaiser, Marcel, Ruiz-Pérez, Luis M., Brun, Reto, Kulikowski, Tadeusz, Johansson, Nils Gunnar, González-Pacanowska, Dolores, Gilbert, Ian H.

Get full text