Search Results - "Colletti, Lynn"

Methods to measure the intracellular concentration of unlabeled compounds within cultured cells using liquid chromatography/tandem mass spectrometry by Colletti, Lynn M., Liu, Yaya, Koev, Gennadiy, Richardson, Paul L., Chen, Chih-Ming, Kati, Warren

“…A high-throughput and sensitive liquid chromatography/tandem mass spectrometry assay was established to detect total unlabeled hepatitis C virus inhibitor…”
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Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir by HICKMAN, Dean, VASAVANONDA, Sudthida, NEQUIST, George, COLLETTI, Lynn, KATI, Warren M, BERTZ, Richard, HSU, Ann, KEMPF, Dale J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Design and synthesis of pseudo-Symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-Hydrazide isostere by Hidaka, Koushi, Kimura, Tooru, Hayashi, Yoshio, McDaniel, Keith F, Dekhtyar, Tatyana, Colletti, Lynn, Kiso, Yoshiaki

“…Pseudo-symmetric HIV-1 protease inhibitors containing a novel HMC-hydrazide isostere as the transition-state mimic were designed and synthesized. Most of the…”
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Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability by Randolph, John T, Krueger, A. Chris, Donner, Pamela L, Pratt, John K, Liu, Dachun, Motter, Christopher E, Rockway, Todd W, Tufano, Michael D, Wagner, Rolf, Lim, Hock B, Beyer, Jill M, Mondal, Rubina, Panchal, Neeta S, Colletti, Lynn, Liu, Yaya, Koev, Gennadiy, Kati, Warren M, Hernandez, Lisa E, Beno, David W. A, Longenecker, Kenton L, Stewart, Kent D, Dumas, Emily O, Molla, Akhteruzzaman, Maring, Clarence J

“…ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the…”
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High potency improvements to weak aryl uracil HCV polymerase inhibitor leads by Donner, Pamela, Randolph, John T., Huang, Peggy, Wagner, Rolf, Maring, Clarence, Lim, Ben Hock, Colletti, Lynn, Liu, Yaya, Mondal, Rubina, Beyer, Jill, Koev, Gennadiy, Marsh, Kennan, Beno, David, Longenecker, Kenton, Pilot-Matias, Tami, Kati, Warren, Molla, Akhter, Kempf, Dale

“…Described herein is the development of a potent non-nucleoside, small molecule inhibitor of genotype 1 HCV NS5B Polymerase. A 23μM inhibitor that was active…”
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2-Pyridyl P1′-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors (A-792611 and A-790742) with Potential for Convenient Dosing and Reduced Side Effects by DeGoey, David A, Grampovnik, David J, Flentge, Charles A, Flosi, William J, Chen, Hui-ju, Yeung, Clinton M, Randolph, John T, Klein, Larry L, Dekhtyar, Tatyana, Colletti, Lynn, Marsh, Kennan C, Stoll, Vincent, Mamo, Mulugeta, Morfitt, David C, Nguyen, Bach, Schmidt, James M, Swanson, Sue J, Mo, Hongmei, Kati, Warren M, Molla, Akhteruzzaman, Kempf, Dale J

“…A series of symmetry-based HIV protease inhibitors was designed and synthesized. Modification of the core regiochemistry and stereochemistry significantly…”
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Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors by Randolph, John T., Huang, Peggy P., Flosi, William J., DeGoey, David, Klein, Larry L., Yeung, Clinton M., Flentge, Charles, Sun, Mingua, Zhao, Chen, Dekhtyar, Tatyana, Mo, Hongmei, Colletti, Lynn, Kati, Warren, Marsh, Kennan C., Molla, Akhteruzzaman, Kempf, Dale J.

“…A series of potent inhibitors of HIV-1 protease designed to be equally effective at inhibiting both wild-type virus and a mutant strain of virus (A17) highly…”
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Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line by Budzik, Gerald P., Colletti, Lynn M., Faltynek, Connie R.

“…It has been proposed that the clinical utility of methotrexate (MTX) in the treatment of rheumatoid arthritis may be due, in part, to inhibition of 5-amino…”
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