Search Results - "Collard, Tracey J"

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis by Greenhough, Alexander, Bagley, Clare, Heesom, Kate J, Gurevich, David B, Gay, David, Bond, Mark, Collard, Tracey J, Paraskeva, Chris, Martin, Paul, Sansom, Owen J, Malik, Karim, Williams, Ann C

“…Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in…”
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BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination by Parker, Christopher, Chambers, Adam C., Flanagan, Dustin J., Ho, Jasmine Wing Yu, Collard, Tracey J., Ngo, Greg, Baird, Duncan M., Timms, Penny, Morgan, Rhys G., Sansom, Owen J., Williams, Ann C.

“…The proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC), where it has been shown to enhance tumour cell survival. However, although…”
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BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells by Legge, Danny N, Shephard, Alex P, Collard, Tracey J, Greenhough, Alexander, Chambers, Adam C, Clarkson, Richard W, Paraskeva, Christos, Williams, Ann C

“…To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a…”
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Identifying targetable metabolic dependencies across colorectal cancer progression by Legge, Danny N., Collard, Tracey J., Stanko, Ewelina, Hoskin, Ashley J., Holt, Amy K., Bull, Caroline J., Kollareddy, Madhu, Bellamy, Jake, Groves, Sarah, Ma, Eric H., Hazelwood, Emma, Qualtrough, David, Amulic, Borko, Malik, Karim, Williams, Ann C., Jones, Nicholas, Vincent, Emma E.

“…Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally…”
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Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer by Hoskin, Ashley J, Holt, Amy K, Legge, Danny N, Collard, Tracey J, Williams, Ann C, Vincent, Emma E

“…Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has a recognized role in cancer prevention as well as evidence to support its use as…”
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Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition by Holt, Amy K, Najumudeen, Arafath K, Collard, Tracey J, Li, Hao, Millett, Laura M, Hoskin, Ashley J, Legge, Danny N, Mortensson, Eleanor M H, Flanagan, Dustin J, Jones, Nicholas, Kollareddy, Madhu, Timms, Penny, Hitchings, Matthew D, Cronin, James, Sansom, Owen J, Williams, Ann C, Vincent, Emma E

“…To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell…”
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Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk by Petherick, Katy J, Williams, Ann C, Lane, Jon D, Ordóñez-Morán, Paloma, Huelsken, Joerg, Collard, Tracey J, Smartt, Helena JM, Batson, Jennifer, Malik, Karim, Paraskeva, Chris, Greenhough, Alexander

“…The Wnt/β‐catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify…”
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The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis by Legge, Danny N, Chambers, Adam C, Parker, Christopher T, Timms, Penny, Collard, Tracey J, Williams, Ann C

“…Abstract With its identification as a proto-oncogene in chronic lymphocytic leukaemia and central role in regulating NF-κB signalling, it is perhaps not…”
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A rapid high throughput bioprinted colorectal cancer spheroid platform for in vitro drug- and radiation-response by Johnson, Peter A, Menegatti, Sara, Chambers, Adam C, Alibhai, Dominic, Collard, Tracey J, Williams, Ann C, Bayley, Hagan, Perriman, Adam W

“…We describe the development of a high-throughput bioprinted colorectal cancer (CRC) spheroid platform with high levels of automation, information content, and…”
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LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs by Al-Kharusi, Manal R A, Smartt, Helena J M, Greenhough, Alexander, Collard, Tracey J, Emery, Elizabeth D, Williams, Ann C, Paraskeva, Chris

“…Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E2 (PGE2), promoting many hallmarks of…”
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BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling by Urban, Bettina C, Collard, Tracey J, Eagle, Catherine J, Southern, Samantha L, Greenhough, Alexander, Hamdollah-Zadeh, Maryam, Ghosh, Anil, Poulsom, Richard, Paraskeva, Christos, Silver, Andrew, Williams, Ann C

“…Colorectal cancer remains the fourth most common cause of cancer-related mortality worldwide. Here we investigate the role of nuclear factor-κB (NF-κB)…”
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The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells by PATIOS, Helena A, GREENHOUGH, Alexander, HICKS, Diane J, MANAL AL KHARUSI, COLLARD, Tracey J, LANE, Jon D, PARASKEVA, Christos, WILLIAMS, Ann C

“…Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal…”
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BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-κB activity by Clemo, Nadine K., Collard, Tracey J., Southern, Samantha L., Edwards, Kieron D., Moorghen, Moganaden, Packham, Graham, Hague, Angela, Paraskeva, Christos, Williams, Ann C.

“…Although expression of the anti-apoptotic protein Bcl-2-associated athanogene-1 (BAG-1) has been reported as up-regulated in a number of malignancies, we show…”
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Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells by H-ZADEH, Akram M, COLLARD, Tracey J, MALIK, Karim, HICKS, Diane J, PARASKEVA, Chris, WILLIAMS, Ann C

“…The insulin-like growth factor binding protein 3 (IGFBP-3) is the major circulating IGF binding protein, its function regulated by proteolytic cleavage. The…”
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Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells by WILLIAMS, A. C, COLLARD, T. J, PERKS, C. M, NEWCOMB, P, MOORGHEN, M, HOLLY, J. M. P, PARASKEVA, C

“…We investigated the expression of insulin-like growth factor binding protein 3 (IGFBP-3) in normal human colonic epithelium and whether IGFBP-3 is involved in…”
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The retinoblastoma protein interacts with Bag‐1 in human colonic adenoma and carcinoma derived cell lines by Arhel, Nathalie J., Packham, Graham, Townsend, Paul A., Collard, Tracey J., H‐Zadeh, Akram M., Sharp, Adam, Cutress, Ramsey I., Malik, Karim, Hague, Angela, Paraskeva, Chris, Williams, Ann C.

“…Although the retinoblastoma susceptibility gene RB1 is inactivated in a wide range of human tumours, overexpression in colonic carcinomas has been linked to…”
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LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE 2 : implications for targeting adenoma stem cells with NSAIDs by Al-Kharusi, Manal R.A., Smartt, Helena J.M., Greenhough, Alexander, Collard, Tracey J., Emery, Elizabeth D., Williams, Ann C., Paraskeva, Chris

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BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells by Skeen, V R, Collard, T J, Southern, S L, Greenhough, A, Hague, A, Townsend, P A, Paraskeva, C, Williams, A C

“…As colorectal cancer remains the second highest cause of cancer-related deaths in much of the industrialised world, identifying novel strategies to prevent…”
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Autolysosomal [beta]-catenin degradation regulates Wnt-autophagy-p62 crosstalk by Petherick, Katy J, Williams, Ann C, Lane, Jon D, Ordóñez-morán, Paloma, Huelsken, Joerg, Collard, Tracey J, Smartt, Helena Jm, Batson, Jennifer, Malik, Karim, Paraskeva, Chris, Greenhough, Alexander

“…The Wnt/[beta]-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we…”
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BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis by Southern, S L, Collard, T J, Urban, B C, Skeen, V R, Smartt, H J, Hague, A, Oakley, F, Townsend, P A, Perkins, N D, Paraskeva, C, Williams, A C

“…Understanding the mechanisms that promote aberrant tumour cell survival is critical for the determination of novel strategies to combat colorectal cancer…”
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