Search Results - "Coll, Joyce T"

Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism by ter Haar, Ernst, Koth, Christopher M., Abdul-Manan, Norzehan, Swenson, Lora, Coll, Joyce T., Lippke, Judith A., Lepre, Christopher A., Garcia-Guzman, Miguel, Moore, Jonathan M.

“…Dysregulation of the calcitonin gene-related peptide (CGRP), a potent vasodilator, is directly implicated in the pathogenesis of migraine. CGRP binds to and…”
Get full text

Refolding and Characterization of a Soluble Ectodomain Complex of the Calcitonin Gene-Related Peptide Receptor by Koth, Christopher M, Abdul-Manan, Norzehan, Lepre, Christopher A, Connolly, Peter J, Yoo, Sanghee, Mohanty, Arun K, Lippke, Judith A, Zwahlen, Jacque, Coll, Joyce T, Doran, John D, Garcia-Guzman, Miguel, Moore, Jonathan M

“…The calcitonin gene-related peptide (CGRP) receptor is a heterodimer of two membrane proteins: calcitonin receptor-like receptor (CLR) and receptor…”
Get full text

Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase by Cheetham, Graham M T, Knegtel, Ronald M A, Coll, Joyce T, Renwick, Suzanne B, Swenson, Lora, Weber, Peter, Lippke, Judith A, Austen, Douglas A

“…Aurora-2 is a key member of a closely related subgroup of serine/threonine kinases that plays important roles in the completion of essential mitotic events…”
Get full text

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis by Xie, Xiaoling, Gu, Yong, Fox, Ted, Coll, Joyce T, Fleming, Mark A, Markland, William, Caron, Paul R, Wilson, Keith P, Su, Michael S-S

“…Background: The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response…”
Get full text

Nonstructural protein 5A (NS5A) and human replication protein A increase the processivity of hepatitis C virus NS5B polymerase activity in vitro by Mani, Nagraj, Yuzhakov, Alexander, Yuzhakov, Olga, Coll, Joyce T, Black, Jim, Saxena, Kumkum, Fulghum, John R, Lippke, Judith A, Rao, B Govinda, Rijnbrand, Rene, Kwong, Ann D

“…The precise role(s) and topological organization of different factors in the hepatitis C virus (HCV) RNA replication complex are not well understood. In order…”
Get full text

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity by Wei, Yunyi, Fox, Ted, Chambers, Steve P, Sintchak, JoAnne, Coll, Joyce T, Golec, Julian MC, Swenson, Lora, Wilson, Keith P, Charifson, Paul S

“…Background: Peptide inhibitors of caspases have helped define the role of these cysteine proteases in biology. Structural and biochemical characterization of…”
Get full text

Development of a protease production platform for structure-based drug design by Fox, Ted, Brennan, Debra, Austen, Douglas A, Swalley, Susanne E, Coll, Joyce T, Raybuck, Scott A, Chambers, Stephen P

“…Structure-based drug design (SBDD) has played an integral role in the development of highly specific, potent protease inhibitors resulting in a number of drugs…”
Get more information

Structure of GSK3β reveals a primed phosphorylation mechanism by ter Haar, Ernst, Coll, Joyce T, Austen, Douglas A, Hsiao, Hsun-Mei, Swenson, Lora, Jain, Jugnu

“…GSK3β was identified as the kinase that phosphorylates glycogen synthase but is now known to be involved in multiple signaling pathways. GSK3β prefers prior…”
Get full text

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase by Fox, Ted, Coll, Joyce T., Xie, Xiaoling, Ford, Pamella J., Germann, Ursula A., Porter, Margaret D., Pazhanisamy, S., Fleming, Mark A., Galullo, Vincent, Su, Michael S. S., Wilson, Keith P.

“…Mitogen‐activated protein (MAP) kinases are serine/threonine kinases that mediate intracellular signal transduction pathways.Pyridinyl imidazole compounds…”
Get full text