Search Results - "Colin Young"

Endoplasmic reticulum stress in the pathogenesis of hypertension by Young, Colin N.

“…New Findings What is the topic of this review? This review highlights the emerging role of disruptions in endoplasmic reticulum (ER) function, namely ER…”
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Circumventricular organ‐hypothalamic circuit endoplasmic reticulum stress drives hepatic steatosis during obesity by Kim, Han Rae, Young, Colin N.

“…Objective Nonalcoholic fatty liver disease (NAFLD), characterized by excess liver triglyceride accumulation (hepatic steatosis), leads to an increased risk for…”
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Angiotensin-II, the Brain, and Hypertension: An Update by Young, Colin N, Davisson, Robin L

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Liver sympathetic denervation reverses obesity‐induced hepatic steatosis by Hurr, Chansol, Simonyan, Hayk, Morgan, Donald A., Rahmouni, Kamal, Young, Colin N.

“…Key points Non‐alcoholic fatty liver disease, characterized in part by elevated liver triglycerides (i.e. hepatic steatosis), is a growing health problem. In…”
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Durable cell and gene therapy potential patient and financial impact: US projections of product approvals, patients treated, and product revenues by Young, Colin M., Quinn, Casey, Trusheim, Mark R.

“…•Durable cell and gene therapy US approvals likely to total 54–74 through 2030.•Therapy class unlikely to threaten health system financial…”
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Estrogen Receptor‐a in the Subfornical Organ Controls Glucose Homeostasis During Obesity in Males by Blackmore, Katherine, Simonyan, Hayk, Young, Colin N.

“…Metabolic syndrome encompasses a spectrum of conditions that increases the risk for adverse cardiovascular and metabolic diseases, including hyperglycemia…”
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Implementation of tissue clearing and 3‐dimensional volumetric imaging approaches for visualization of anatomical structures in autonomic nuclei by Arestakesyan, Hovhannes, Young, Colin N.

“…Alterations within central nervous system (CNS) autonomic nuclei contribute to a wide array of diseases. In this context, significant advancements have been…”
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Inhibition of Forebrain Microglia Ameliorates Non‐alcoholic Fatty Liver Disease During Obesity by Kim, Han Rae, Young, Colin N.

“…Non‐alcoholic fatty liver disease (NAFLD), characterized by increased hepatic triglycerides (i.e. steatosis), leads to an increased risk for type II diabetes,…”
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Influence of Carbon Nanotube Characteristics on Macroscopic Fiber Properties by Tsentalovich, Dmitri E, Headrick, Robert J, Mirri, Francesca, Hao, Junli, Behabtu, Natnael, Young, Colin C, Pasquali, Matteo

“…We study how intrinsic parameters of carbon nanotube (CNT) samples affect the properties of macroscopic CNT fibers with optimized structure. We measure CNT…”
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Cost-effectiveness of a hypothetical cell or gene therapy cure for sickle cell disease by Salcedo, Jonathan, Bulovic, Jenniffer, Young, Colin M.

“…Sickle cell disease (SCD) is a group of inherited genetic conditions associated with lifelong complications and increased healthcare resource utilization…”
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High-Performance Carbon Nanotube Transparent Conductive Films by Scalable Dip Coating by Mirri, Francesca, Ma, Anson W. K, Hsu, Tienyi T, Behabtu, Natnael, Eichmann, Shannon L, Young, Colin C, Tsentalovich, Dmitri E, Pasquali, Matteo

“…Transparent conductive carbon nanotube (CNT) films were fabricated by dip-coating solutions of pristine CNTs dissolved in chlorosulfonic acid (CSA) and then…”
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High-Ampacity Power Cables of Tightly-Packed and Aligned Carbon Nanotubes by Wang, Xuan, Behabtu, Natnael, Young, Colin C., Tsentalovich, Dmitri E., Pasquali, Matteo, Kono, Junichiro

“…The current‐carrying capacity (CCC), or ampacity, of highly‐conductive, light, and strong carbon nanotube (CNT) fibers is characterized by measuring their…”
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Sexual Dimorphism in Brain Cellular Senescence During Angiotensin II‐Induced Hypertension by Dow, Samantha A., Arestakesyan, Hovhannes, Young, Colin N.

“…Sex differences in the development of hypertension across the lifespan are well established. Women are at lower risk of hypertension compared to age‐matched…”
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Angiotensin‐II, insulin, and NELL2 involvement in forebrain synaptic circuit modifications during hypertension by Jeong, Jin Kwon, Kim, Dong Hee, Lee, Byung Ju, Young, Colin N.

“…The central nervous system (CNS) is strongly implicated in cardiovascular disease development including hypertension. In particular, alterations in the…”
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Large-field-of-view scanning electron microscopy of the paraventricular nucleus of the hypothalamus during diet-induced obesity by Arestakesyan, Hovhannes, Blackmore, Katherine, Smith, Hannah C, Popratiloff, Anastas, Young, Colin N

“…Dysregulation in the paraventricular nucleus of the hypothalamus (PVN) is associated with a variety of diseases including those related to obesity. Although…”
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Large Flake Graphene Oxide Fibers with Unconventional 100% Knot Efficiency and Highly Aligned Small Flake Graphene Oxide Fibers by Xiang, Changsheng, Young, Colin C., Wang, Xuan, Yan, Zheng, Hwang, Chi-Chau, Cerioti, Gabriel, Lin, Jian, Kono, Junichiro, Pasquali, Matteo, Tour, James M.

“…Two types of graphene oxide fibers are spun from high concentration aqueous dopes. Fibers extruded from large flake graphene oxide dope without drawing show…”
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Strong, Light, Multifunctional Fibers of Carbon Nanotubes with Ultrahigh Conductivity by Behabtu, Natnael, Young, Colin C., Tsentalovich, Dmitri E., Kleinerman, Olga, Wang, Xuan, Ma, Anson W. K., Bengio, E. Amram, Waarbeek, Ron F. ter, de Jong, Jorrit J., Hoogerwerf, Ron E., Fairchild, Steven B., Ferguson, John B., Maruyama, Benji, Kono, Junichiro, Talmon, Yeshayahu, Cohen, Yachin, Otto, Marcin J., Pasquali, Matteo

“…Broader applications of carbon nanotubes to real-world problems have largely gone unfulfilled because of difficult material synthesis and laborious processing…”
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Maximum Entropy Models for Fatigue Damage in Metals with Application to Low-Cycle Fatigue of Aluminum 2024-T351 by Young, Colin, Subbarayan, Ganesh

“…In the present work, we propose using the cumulative distribution functions derived from maximum entropy formalisms, utilizing thermodynamic entropy as a…”
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Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR-T Therapies for the Treatment of Cancer (1997–2020) by Ivica, Nikola A., Young, Colin M.

“…Chimeric antigen receptor and T-cell receptor (CAR-T/TCR-T) cellular immunotherapies have shown remarkable success in the treatment of some refractory B-cell…”
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HDAC6 Plays a Noncanonical Role in the Regulation of Antitumor Immune Responses, Dissemination, and Invasiveness of Breast Cancer by Banik, Debarati, Noonepalle, Satish, Hadley, Melissa, Palmer, Erica, Gracia-Hernandez, Maria, Zevallos-Delgado, Christian, Manhas, Namratta, Simonyan, Hayk, Young, Colin N, Popratiloff, Anastas, Chiappinelli, Katherine B, Fernandes, Rohan, Sotomayor, Eduardo M, Villagra, Alejandro

“…Despite the outstanding clinical results of immune checkpoint blockade (ICB) in melanoma and other cancers, clinical trials in breast cancer have reported low…”
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