Search Results - "Colin Smith"

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging by Wardlaw, Joanna M, Prof, Smith, Colin, MD, Dichgans, Martin, Prof

“…Summary The term cerebral small vessel disease (SVD) describes a range of neuroimaging, pathological, and associated clinical features. Clinical features range…”
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The stress function basis of the upper bound theorem of plasticity by Smith, Colin C., Gilbert, Matthew

“…The discontinuous slip-line form of upper bound plasticity analysis is considered using an equilibrium of forces approach. It is demonstrated that the…”
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Backrub-Like Backbone Simulation Recapitulates Natural Protein Conformational Variability and Improves Mutant Side-Chain Prediction by Smith, Colin A., Kortemme, Tanja

“…Incorporation of effective backbone sampling into protein simulation and design is an important step in increasing the accuracy of computational protein…”
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Predicting the tolerated sequences for proteins and protein interfaces using RosettaBackrub flexible backbone design by Smith, Colin A, Kortemme, Tanja

“…Predicting the set of sequences that are tolerated by a protein or protein interface, while maintaining a desired function, is useful for characterizing…”
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Medial knee loading is altered in subjects with early osteoarthritis during gait but not during step-up-and-over task by Meireles, Susana, Wesseling, Mariska, Smith, Colin R, Thelen, Darryl G, Verschueren, Sabine, Jonkers, Ilse

“…This study evaluates knee joint loading during gait and step-up-and-over tasks in control subjects, subjects with early knee OA and those with established knee…”
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Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis by TRIPKOVIC, Laura, LAMBERT, Helen, LANHAM-NEW, Susan, HART, Kathryn, SMITH, Colin P, BUCCA, Giselda, PENSON, Simon, CHOPE, Gemma, HYPPÖNEN, Elina, BERRY, Jacqueline, VIETH, Reinhold

“…Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising…”
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Perspective: A resident's role in promoting safe machine learning tools in sleep medicine by Smith, Colin M, Vendrame, Martina

“…Residents and fellows can play a helpful role in promoting safe and effective machine learning tools in sleep medicine. Here we highlight the importance of…”
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A Web Resource for Standardized Benchmark Datasets, Metrics, and Rosetta Protocols for Macromolecular Modeling and Design by Ó Conchúir, Shane, Barlow, Kyle A, Pache, Roland A, Ollikainen, Noah, Kundert, Kale, O'Meara, Matthew J, Smith, Colin A, Kortemme, Tanja

“…The development and validation of computational macromolecular modeling and design methods depend on suitable benchmark datasets and informative metrics for…”
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Listen to E-scooter riders: Mining rider satisfaction factors from app store reviews by Aman, Javad J.C., Smith-Colin, Janille, Zhang, Wenwen

“…•Analyzed 12,026 reviews to identify factors associated with rider satisfaction.•Investigated the impact of gender on riding experience and satisfaction…”
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Limit analysis of masonry walls using discontinuity layout optimization and homogenization by Valentino, John, Gilbert, Matthew, Gueguin, Maxime, Smith, Colin C.

“…A numerical limit analysis model for masonry walls subject to in‐plane loading is posed as a discontinuity layout optimization (DLO) problem, with the masonry…”
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Sustainable biopolymer soil stabilization in saline rich, arid conditions: a ‘micro to macro’ approach by Armistead, Samuel J., Smith, Colin C., Staniland, Sarah S.

“…Water scarcity in semi-arid/arid regions is driving the use of salt water in mining operations. A consequence of this shift, is the potentially unheeded effect…”
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The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2) by Jeong, Yujin, Kim, Ji-Nu, Kim, Min Woo, Bucca, Giselda, Cho, Suhyung, Yoon, Yeo Joon, Kim, Byung-Gee, Roe, Jung-Hye, Kim, Sun Chang, Smith, Colin P., Cho, Byung-Kwan

“…Individual Streptomyces species have the genetic potential to produce a diverse array of natural products of commercial, medical and veterinary interest…”
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Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome by Möller-Levet, Carla S, Archer, Simon N, Bucca, Giselda, Laing, Emma E, Slak, Ana, Kabiljo, Renata, Lo, June C Y, Santhi, Nayantara, von Schantz, Malcolm, Smith, Colin P, Dijk, Derk-Jan

“…Insufficient sleep and circadian rhythm disruption are associated with negative health outcomes, including obesity, cardiovascular disease, and cognitive…”
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Mistimed sleep disrupts circadian regulation of the human transcriptome by Archer, Simon N, Laing, Emma E, Möller-Levet, Carla S, van der Veen, Daan R, Bucca, Giselda, Lazar, Alpar S, Santhi, Nayantara, Slak, Ana, Kabiljo, Renata, von Schantz, Malcolm, Smith, Colin P, Dijk, Derk-Jan

“…Circadian organization of the mammalian transcriptome is achieved by rhythmic recruitment of key modifiers of chromatin structure and transcriptional and…”
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Genetic variability in the regulation of gene expression in ten regions of the human brain by Ramasamy, Adaikalavan, Trabzuni, Daniah, Guelfi, Sebastian, Varghese, Vibin, Smith, Colin, Walker, Robert, De, Tisham, Coin, Lachlan, de Silva, Rohan, Cookson, Mark R, Singleton, Andrew B, Hardy, John, Ryten, Mina, Weale, Michael E

“…Expression quantitative trait loci (eQTLs) are genomic regions that regulate gene expression. Here the authors provide a publicly available data set of…”
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Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging by Soreq, Lilach, Rose, Jamie, Soreq, Eyal, Hardy, John, Trabzuni, Daniah, Cookson, Mark R., Smith, Colin, Ryten, Mina, Patani, Rickie, Ule, Jernej

“…Gene expression studies suggest that aging of the human brain is determined by a complex interplay of molecular events, although both its region- and…”
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Prediction and Validation of Load-Dependent Behavior of the Tibiofemoral and Patellofemoral Joints During Movement by Lenhart, Rachel L., Kaiser, Jarred, Smith, Colin R., Thelen, Darryl G.

“…The study objective was to construct and validate a subject-specific knee model that can simulate full six degree of freedom tibiofemoral and patellofemoral…”
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Widespread sex differences in gene expression and splicing in the adult human brain by Trabzuni, Daniah, Ramasamy, Adaikalavan, Imran, Sabaena, Walker, Robert, Smith, Colin, Weale, Michael E., Hardy, John, Ryten, Mina

“…There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and…”
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Structure-Based Prediction of the Peptide Sequence Space Recognized by Natural and Synthetic PDZ Domains by Smith, Colin A., Kortemme, Tanja

“…Protein–protein recognition, frequently mediated by members of large families of interaction domains, is one of the cornerstones of biological function. Here,…”
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Patient-specific gait pattern in individuals with patellofemoral instability reduces knee joint loads by Guggenberger, Bernhard, Horsak, Brian, Habersack, Andreas, Kruse, Annika, Smith, Colin R., Kainz, Hans, Svehlik, Martin

“…Patellofemoral instability is influenced by morphological factors and associated with compensational alterations in gait pattern. Recent simulation studies…”
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