Search Results - "Coletta, PL"

Non‐invasive molecular imaging for preclinical cancer therapeutic development by O'Farrell, AC, Shnyder, SD, Marston, G, Coletta, PL, Gill, JH

“…Molecular and non‐invasive imaging are rapidly emerging fields in preclinical cancer drug discovery. This is driven by the need to develop more efficacious and…”
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The omega‐3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC‐26 colorectal cancer cell liver metastasis via inhibition of PGE2‐dependent cell motility by Hawcroft, G, Volpato, M, Marston, G, Ingram, N, Perry, SL, Cockbain, AJ, Race, AD, Munarini, A, Belluzzi, A, Loadman, PM, Coletta, PL, Hull, MA

“…BACKGROUND AND PURPOSE The omega‐3 polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA) has antineoplastic activity at early stages of colorectal…”
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Abstract P2-04-04: Developing targeted therapeutic microbubbles for enhanced epigenetic drug delivery for breast cancer by Alataki, A, Abou-Saleh, R, McLaughlan, JR, Markham, AF, Evans, SD, Coletta, PL, Valleley, EM

“…Background: In recent years, there has been great interest in developing drugs that modify epigenetic changes as new therapies for breast cancer (BC). There is…”
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The omega‐3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC‐26 colorectal cancer cell liver metastasis via inhibition of PGE 2 ‐dependent cell motility by Hawcroft, G, Volpato, M, Marston, G, Ingram, N, Perry, SL, Cockbain, AJ, Race, AD, Munarini, A, Belluzzi, A, Loadman, PM, Coletta, PL, Hull, MA

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Macrophage Migration Inhibitory Factor Promotes Intestinal Tumorigenesis by Wilson, Jonathan M., Coletta, P. Louise, Cuthbert, Richard J., Scott, Nigel, MacLennan, Kenneth, Hawcroft, Gillian, Leng, Lin, Lubetsky, Jodi B., Jin, Kai K., Lolis, Elias, Medina, Francisco, Brieva, Jose A., Poulsom, Richard, Markham, Alexander F., Bucala, Richard, Hull, Mark A.

“…Background & Aims: The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic…”
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Localization of Cyclooxygenase-2 in Human Sporadic Colorectal Adenomas by Chapple, Keith S., Cartwright, Elizabeth J., Hawcroft, Gillian, Tisbury, Alison, Bonifer, Constanze, Scott, Nigel, Windsor, Alistair C.J., Guillou, Pierre J., Markham, Alexander F., Coletta, P. Louise, Hull, Mark A.

“…A putative target for the anti-colorectal cancer action of nonsteroidal anti-inflammatory drugs is the inducible isoform of cyclooxygenase (COX), COX-2. COX-2…”
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Lack of interleukin-4 receptor α chain-dependent signalling promotes azoxymethane-induced colorectal aberrant crypt focus formation in Balb/c mice by Ko, CWS, Cuthbert, RJ, Orsi, NM, Brooke, DA, Perry, SL, Markham, AF, Coletta, PL, Hull, MA

“…Interleukin (IL)-4 receptor (IL-4R) α chain-dependent signalling by IL-4 and IL-13 promotes tumour growth and metastasis in mouse models of colorectal cancer…”
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Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the ApcMin/+ mouse by Scott, Daniel J., Hull, Mark A., Cartwright, Elizabeth J., Lam, Wai K., Tisbury, Alison, Poulsom, Richard, Markham, Alexander F., Bonifer, Constanze, Coletta, P.Louise

“…Background & Aims: The role of the inducible isoform of nitric oxide synthase (Nos2 or iNOS) in intestinal tumorigenesis is unclear. Conflicting data also…”
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Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice by HULL, M. A, BOOTH, J. K, TISBURY, A, SCOTT, N, BONIFER, C, MARKHAM, A. F, COLETTA, P. L

“…Expression of cyclooxygenase 2 (COX-2) is believed to play an important role in adenoma formation in murine polyposis models, and inhibition of COX-2 activity…”
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Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours by Scott, N, Millward, E, Cartwright, E J, Preston, S R, Coletta, P L

“…Aims: To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours. Methods:…”
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Interstitial cell cyclooxygenase-2 expression is associated with increased angiogenesis in human sporadic colorectal adenomas by Chapple, Keith S, Scott, Nigel, Guillou, Pierre J, Coletta, P Louise, Hull, Mark A

“…Cyclooxygenase (COX)‐2 plays an important role in intestinal tumorigenesis and angiogenesis in animal models. In superficial areas of human sporadic colorectal…”
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Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells by Ko, Stanley C W, Chapple, Keith S, Hawcroft, Gillian, Coletta, P Louise, Markham, Alexander F, Hull, Mark A

“…In human colorectal adenomas or polyps, cyclooxygenase-2 is expressed predominantly by stromal (or interstitial) macrophages. Therefore, we tested the…”
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Efficient infection and persistence of a herpesvirus saimiri-based gene delivery vector into human tumor xenografts and multicellular spheroid cultures by Smith, Peter G, Burchill, Sue A, Brooke, David, Coletta, P Louise, Whitehouse, Adrian

“…Herpesvirus saimiri (HVS) has the ability to infect a variety of human cell lines and establish a persistent infection by virtue of episomal maintenance…”
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Analysis of cyclooxygenase expression in human colorectal adenomas by Chapple, Keith S, Scott, Nigel, Guillou, Pierre J, Coletta, P Louise, Hull, Mark A

“…Evidence from rodent intestinal tumorigenesis models suggests that both cyclooxygenase-1 and cyclooxygenase-2 may play important roles in the development and…”
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An enhancer sequence directs LacZ expression to developing pharyngeal endoderm in transgenic mice by Parmar, Hema, Coletta, P. Louise, Faruque, Nadeem, Sharpe, Paul T.

“…The murine Hoxc‐6 homeobox gene comprises three exons with two distinct promoters (PRI and PRII) located 9 kb apart. To characterise the PRII promoter, a…”
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In vivo episomal maintenance of a herpesvirus saimiri-based gene delivery vector by SMITH, P. G, COLETTA, P. L, MARKHAM, A. F, WHITEHOUSE, A

“…Herpesvirus saimiri (HVS) has several properties that make it amenable to development as a gene delivery vector. HVS offers the potential to incorporate large…”
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The herpesvirus saimiri ORF 73 regulatory region provides long-term transgene expression in human carcinoma cell lines by Giles, Mathew S, Smith, Peter G, Coletta, P Louise, Hall, Kersten T, Whitehouse, Adrian

“…Herpesvirus saimiri (HVS) is capable of establishing a persistent infection in a variety of human carcinoma cell lines, by virtue of episomal maintenance…”
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Cyclooxygenase-2 is localized to lamina propria cells in Min mouse intestine by Hull, MA, Booth, JK, Scott, N, Markham, AF, Coletta, PL

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Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network by GAUNT, S. J, COLETTA, P. L, PRAVTCHEVA, D, SHARPE, P. T

“…A putative mouse homeobox gene (Hox-3.4) was previously identified 4kb downstream of the Hox-3.3 (Hox-6.1)* gene (Sharpe et al. 1988). We have now sequenced…”
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Molecular analysis of the presenilin 1 (S182) gene in "sporadic" cases of Alzheimer's disease: identification and characterisation of unusual splice variants by Anwar, R, Moynihan, T P, Ardley, H, Brindle, N, Coletta, P L, Cairns, N, Markham, A F, Robinson, P A

“…Mutations of the presenilin 1 (PS-1) gene at the Alzheimer's disease (AD) FAD3 locus on chromosome 14q24.3 are responsible for the majority of familial…”
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