Search Results - "Coles, Steven J"

An unexplored role for Peroxiredoxin in exercise-induced redox signalling? by Wadley, Alex J, Aldred, Sarah, Coles, Steven J

“…Peroxiredoxin (PRDX) is a ubiquitous oxidoreductase protein with a conserved ionised thiol that permits catalysis of hydrogen peroxide (H2O2) up to a million…”
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High intensity interval exercise increases the frequency of peripheral PD-1+ CD8+ central memory T-cells and soluble PD-L1 in humans by Wadley, Alex J., Cullen, Tom, Vautrinot, Jordan, Keane, Gary, Bishop, Nicolette C., Coles, Steven J.

“…Exercise can exert anti-inflammatory effects in an intensity-dependent manner; however, the mechanisms mediating these effects are continually being…”
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The BCAT1 CXXC Motif Provides Protection against ROS in Acute Myeloid Leukaemia Cells by Hillier, James, Allcott, Gemma J, Guest, Laura A, Heaselgrave, Wayne, Tonks, Alex, Conway, Myra E, Cherry, Amy L, Coles, Steven J

“…The cytosolic branched-chain aminotransferase (BCAT1) has received attention for its role in myeloid leukaemia development, where studies indicate metabolic…”
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The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine by WALSBY, Elisabeth J, COLES, Steven J, KNAPPER, Steven, BURNETT, Alan K

“…Topoisomerase II is essential for the maintenance of DNA integrity and the survival of proliferating cells. Topoisomerase II poisons, including etoposide and…”
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Detecting intracellular thiol redox state in leukaemia and heterogeneous immune cell populations: An optimised protocol for digital flow cytometers by Wadley, Alex J., Morgan, Rhys G., Heesom, Kate J., Hole, Paul S., Coles, Steven J.

“…[Display omitted] Flow cytometric methods for detecting and quantifying reduced intracellular thiol content using fluorescein-5-maleimide (F5M) in viable…”
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Plasma concentrations of thioredoxin, thioredoxin reductase and peroxiredoxin-4 can identify high risk patients and predict outcome in patients with acute coronary syndrome: A clinical observation by Doughty, Angela, Keane, Gary, Wadley, Alex J., Mahoney, Berenice, Bueno, Allain A., Coles, Steven J.

“…Oxidative stress is a pathological feature of acute coronary syndrome (ACS), a complex disease with varying clinical outcomes. Surrogate biomarkers of…”
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Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase by Coles, Steven J., Hancock, John T., Conway, Myra E.

“…The human branched-chain isoenzymes are CXXC motif aminotransferase （hBCAT） redox sensitive homodimers central to glutamate metabolism in the central nervous…”
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Use of an anti‐CD200‐blocking antibody improves immune responses to AML in vitro and in vivo by Rastogi, Namrata, Baker, Sarah, Man, Stephen, Uger, Robert A., Wong, Mark, Coles, Steven J., Hodges, Marie, Gilkes, Amanda F., Knapper, Steven, Darley, Richard L., Tonks, Alex

“…Summary Treatment of relapsed/resistant acute myeloid leukaemia (AML) remains a significant area of unmet patient need, the outlook for most patients remaining…”
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Characterization of extracellular redox enzyme concentrations in response to exercise in humans by Wadley, Alex J, Keane, Gary, Cullen, Tom, James, Lynsey, Vautrinot, Jordan, Davies, Matthew, Hussey, Bethan, Hunter, David J, Mastana, Sarabjit, Holliday, Adrian, Petersen, Steen V, Bishop, Nicolette C, Lindley, Martin R, Coles, Steven J

“…Redox enzymes modulate intracellular redox balance and are secreted in response to cellular oxidative stress, potentially modulating systemic inflammation…”
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Preliminary evidence of reductive stress in human cytotoxic T-cells following exercise by Wadley, Alex James, Holliday, Adrian, Morgan, Rhys G, Heesom, Kate J, Aldred, Sarah, Peters, Derek M, Bueno, Allain A, Coles, Steven J

“…This study investigated immunophenotypic differences in intracellular thiol redox state of peripheral blood mononuclear cells (PBMCs) isolated from trained…”
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Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations by Wadley, Alex J, Morgan, Rhys G, Darley, Richard L, Hole, Paul S, Coles, Steven J

“…Increased production of reactive oxygen species (ROS) and deficiencies in cellular antioxidant defenses are the principal causes of cellular oxidative stress…”
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Regulatory Control of Human Cytosolic Branched-Chain Aminotransferase by Oxidation and S-Glutathionylation and Its Interactions with Redox Sensitive Neuronal Proteins by Conway, Myra E, Coles, Steven J, Islam, Mohammad M, Hutson, Susan M

“…Redox regulation of proteins through oxidation and S-thiolation are important regulatory processes, acting in both a protective and adaptive role in the cell…”
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S-Nitrosoglutathione Inactivation of the Mitochondrial and Cytosolic BCAT Proteins: S-Nitrosation and S-Thiolation by Coles, Steven J, Easton, Peter, Sharrod, Hayley, Hutson, Susan M, Hancock, John, Patel, Vinood B, Conway, Myra E

“…Specific proteins with reactive thiol(ate) groups are susceptible to nitric oxide (NO) modification, which can result in S-nitrosation, S-thiolation, or…”
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Narrative Intelligence from the Bottom Up: A Computational Framework for the Study of Story-Telling in Autonomous Agents by Dautenhahn, Kerstin, Coles, Steven J

“…This paper addresses Narrative Intelligence from a bottom up, Artificial Life perspective. First, different levels of narrative intelligence are discussed in…”
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Over-Expression of CD200 In Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-Lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity by Coles, Steven J, Man, Stephen, Hills, Robert, Wang, Eddie CY, Burnett, Alan, Darley, Richard L, Tonks, Alex

“…Abstract 491 CD200 is a type-1 transmembrane glycoprotein which suppresses inflammatory and autoimmune responses by signalling through its cognate…”
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