Search Results - "Coleman, Robert S"

Total Synthesis of 2‘-O-Methylmyxalamide D and (6E)-2‘-O-Methylmyxalamide D by Coleman, Robert S, Lu, Xiaoling, Modolo, Isabelle

“…Hetero-bis-metalated 1,3,5-hexatrienes are employed in the linchpin coupling of synthetic fragments for the convergent construction of the central pentaene of…”
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Ultrafast Dynamics in DNA:  “Fraying” at the End of the Helix by Andreatta, Daniele, Sen, Sobhan, Pérez Lustres, J. Luis, Kovalenko, Sergey A, Ernsting, Nikolaus P, Murphy, Catherine J, Coleman, Robert S, Berg, Mark A

“…The dynamics of the electric fields in the interior of DNA are measured by using oligonucleotides in which a native base pair is replaced by a dye molecule…”
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Power-Law Solvation Dynamics in DNA over Six Decades in Time by Andreatta, Daniele, Pérez Lustres, J. Louis, Kovalenko, Sergey A, Ernsting, Nikolaus P, Murphy, Catherine J, Coleman, Robert S, Berg, Mark A

“…Time-resolved Stokes shifts in a dye-containing oligonucleotide have been observed over the entire time range from 40 fs to 40 ns. The dynamics fit to a power…”
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Total Synthesis of Lucilactaene, A Cell Cycle Inhibitor Active in p53-Inactive Cells by Coleman, Robert S, Walczak, Matthew C, Campbell, Erica L

“…Hetero-bis-metalated 1,3-butadiene is employed in the lynchpin coupling of synthetic fragments of the side chain of the antitumor agent, lucilactaene…”
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Divergent and Stereocontrolled Synthesis of the Enamide Side Chains of Oximidines I/II/III, Salicylihalamides A/B, Lobatamides A/D, and CJ-12,950 by Coleman, Robert S, Liu, Pei-Hua

“…A unified strategy for the divergent and stereocontrolled introduction of the (E)- and (Z)-enamide side-chains of oximidines I, II, and III, salicylihalamides…”
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Total Synthesis of Eupomatilones 4 and 6:  Structurally Rearranged and Atropisomerically Fluxional Lignan Natural Products by Coleman, Robert S, Gurrala, Srinivas Reddy

“…A convergent and diastereocontrolled total synthesis of eupomatilones 4 and 6 is reported and was based on a diastereoselective hydroboration/oxidation…”
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Total synthesis of strobilurin B using a hetero-bis-metallated pentadiene linchpin by Coleman, Robert S, Lu, Xiaoling

“…An efficient, six-step stereocontrolled total synthesis of the antifungal agent strobilurin B is reported and was based on a convergent bi-directional coupling…”
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Mitomycin Synthetic Studies:  Stereocontrolled and Convergent Synthesis of a Fully Elaborated Aziridinomitosane by Coleman, Robert S, Felpin, François-Xavier, Chen, Wei

“…Full details of a stereocontrolled and convergent synthetic route to 9a-desmethoxymitomycin A (1) are reported. The target molecule possesses the parent…”
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Measurement of Local DNA Reorganization on the Picosecond and Nanosecond Time Scales by Brauns, Eric B, Madaras, Mihaela L, Coleman, Robert S, Murphy, Catherine J, Berg, Mark A

“…Picosecond and nanosecond dynamics in the interior of DNA are observed for the first time as a dynamic Stokes shift in the fluorescence of a specially designed…”
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Studies on the Mechanism of Action of Azinomycin B:  Definition of Regioselectivity and Sequence Selectivity of DNA Cross-Link Formation and Clarification of the Role of the Naphthoate by Coleman, Robert S, Perez, Ronelito J, Burk, Christopher H, Navarro, Antonio

“…Evaluation of the sequence selectivity, noncovalent association, and orientation of the DNA cross-linking agent azinomycin B on its duplex DNA receptor is…”
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Synthesis of a Novel Coumarin C-Riboside as a Photophysical Probe of Oligonucleotide Dynamics by Coleman, Robert S, Madaras, Mihaela L

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DNA Cross-Linking by Azinomycin B:  Monte Carlo Simulations in the Evaluation of Sequence Selectivity by Alcaro, Stefano, Ortuso, Francesco, Coleman, Robert S

“…A new set of charges specifically developed for biologically relevant N7-alkylated purine adducts have been implemented in the AMBER* force field of the…”
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Stereocontrolled Synthesis of the Diene and Triene Macrolactones of Oximidines I and II:  Organometallic Coupling versus Standard Macrolactonization by Coleman, Robert S, Garg, Rahul

“…Stereocontrolled construction of the 12-membered diene and triene lactones 1, 2, and 3, characteristic of the antitumor agent oximidines I and II, are reported…”
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Total Synthesis of the Eupomatilones by Mitra, Soumya, Gurrala, Srinivas Reddy, Coleman, Robert S

“…Full details of the total syntheses of five members of the eupomatilone family of lignans are reported…”
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Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics by Shi, Wei, Coleman, Robert S, Lowary, Todd L

“…Anthracycline antibiotics such as daunomycin (Dauno) and doxorubicin (Dox) are well-known clinically used cancer chemotherapeutics, which, among other…”
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Nanoscale structure and dynamics of DNA by Berg, Mark A, Coleman, Robert S, Murphy, Catherine J

“…DNA is depicted in elementary chemistry and biology texts as a perfect double helix; but local structural variations and nanoscale motions within the double…”
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A Direct and Efficient Total Synthesis of the Tubulin-Binding Agents Ceratamine A and B; Use of IBX for a Remarkable Heterocycle Dehydrogenation by Coleman, Robert S, Campbell, Erica L, Carper, Daniel J

“…The total synthesis of the tubulin-binding agents ceratamine A and B is reported, along with des-methyl analogs, via a synthetic route that is high-yielding…”
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Tandem Stille/Suzuki−Miyaura Coupling of a Hetero-Bis-metalated Diene. Rapid, One-Pot Assembly of Polyene Systems by Coleman, Robert S, Walczak, Matthew C

“…The synthesis of a hetero-bis-metallo 1,3-butadiene is reported, and its use as an orthogonal Stille and Suzuki−Miyaura coupling partner is detailed. The…”
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Synthesis and Postsynthetic Modification of Oligodeoxynucleotides Containing 4-Thio-2'-deoxyuridine (ds4U) by Coleman, Robert S, Kesicki, Edward A

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Coumarin base-pair replacement as a fluorescent probe of ultrafast DNA dynamics by Coleman, Robert S., Berg, Mark A., Murphy, Catherine J.

“…The design and synthesis of a novel coumarin C-riboside are described, and is based on the well-known photoprobe Coumarin 102. A diastereofacial selective Heck…”
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