Search Results - "Coleman, P D"

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease by West, M J, Coleman, P D, Flood, D G, Troncoso, J C

“…The distinction between the neurodegenerative changes that accompany normal ageing and those that characterise Alzheimer's disease is not clear. The resolution…”
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Neurons May Live for Decades with Neurofibrillary Tangles by Morsch, Renee, Simon, William, Coleman, Paul D

“…Neurons containing neurofibrillary tangles (NFT) are one of the pathological hallmarks of Alzheimer disease (AD). It is known that this population of neurons…”
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Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures by O'Banion, M K, Miller, J C, Chang, J W, Kaplan, M D, Coleman, P D

“…Activation of glial cells and the consequent release of cytokines, proteins, and other intercellular signaling molecules is a well-recognized phenomenon in…”
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PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease by Utal, A.K, Stopka, A.L, Roy, M, Coleman, P.D

“…We have investigated the distribution of PEP-19, a neuron-specific protein, in the adult human brain. Immunohistochemistry for PEP-19 appears to define the…”
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Quantitative Decrease in Synaptophysin Message Expression and Increase in Cathepsin D Message Expression in Alzheimer Disease Neurons Containing Neurofibrillary Tangles by Callahan, Linda M, Vaules, William A, Coleman, Paul D

“…Combining immunocytochemistry with in situ hybridization of Alzheimer disease (AD) hippocampus demonstrated a 50% reduction in grain density for synaptophysin…”
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Synaptic slaughter in Alzheimer’s disease by Coleman, Paul D., Yao, Pamela J.

“…Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer’s disease (AD) [Ann. Neurol. 27 (1990) 457;…”
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Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry by Yao, P.J., Morsch, R., Callahan, L.M., Coleman, P.D.

“…Clathrin assembly protein AP180 plays a regulatory role in clathrin-mediated synaptic vesicle recycling in synapses. Previously, using immunoblot analysis, we…”
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Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease by Yao, Pamela J, Coleman, Paul D

“…Synapse loss is one of the neuropathologies in Alzheimer's disease (AD) that may play a crucial role in the mechanism of its distinct cognitive impairment and…”
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Selective vulnerability and early progression of hippocampal CA1 pyramidal cell degeneration and GFAP-positive astrocyte reactivity in the rat four-vessel occlusion model of transient global ischemia by Ordy, J M, Wengenack, T M, Bialobok, P, Coleman, P D, Rodier, P, Baggs, R B, Dunlap, W P, Kates, B

“…Selective, delayed-onset vulnerability of hippocampal CA1 pyramidal cells has been reported as a unique phenomenon in man and the rat four-vessel occlusion…”
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Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease by Callahan, Linda M., Coleman, Paul D.

“…The observation that neurons containing neurofibrillary tangles are usually adjacent to neurons free of any morphological indication of disease, suggests the…”
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Are Doppler studies a useful method of assessing neovascularization in human Achilles tendinopathy? A systematic review and suggestions for optimizing machine settings by Yang, X., Pugh, N. D., Coleman, D. P., Nokes, L. D. M.

“…Achilles tendinopathy describes a painful condition. The symptoms include localized swelling and tenderness, and the condition is often associated with altered…”
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Research Uses of Neuropathological Data by Coleman, P.D

“…The study of relationships between neuropathological characteristics and behavioral, structural, chemical, and molecular variables offers immense promise for…”
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Development and validation of an in vivo analysis tool to identify changes in carotid plaque tissue types in serial 3-D ultrasound scans by Coleman, D P, Rakebrandt, F, Pugh, N D, Crawford, D C, Woodcock, J P

“…We have developed a three-dimensional (3-D) B-mode acquisition system suitable for imaging carotid plaques in vivo. A texture classification system using 157…”
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Non-HPLC separation of water-soluble choline metabolites by two-dimensional high voltage electrophoresis and thin layer chromatography by Utal, A.K, Coleman, P.D

“…In cholinergic neurons choline is directed to three main pathways; (1) conversion to phosphorylcholine (PCh) and cytidine diphosphate choline (CDP-choline) for…”
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Analysis of Message Expression in Single Neurons of Alzheimer’s Disease Brain by Callahan, L.M, Chow, N, Cheetham, J.E, Cox, C, Coleman, P.D

“…Because many cell types and disease states exist in the sample of cells in even a very small region of Alzheimer’s disease (AD) brain tissue, optimal…”
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Comparative Metabolism and Disposition of Gemfibrozil in Male and Female Sprague-Dawley Rats and Syrian golden Hamsters by DIX, K. J, COLEMAN, D. P, JEFFCOAT, A. R

“…Gemfibrozil, a human pharmaceutical agent, causes hepatomegaly and hepatic peroxisome proliferation in rats, which have been associated with…”
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Low Initial Tau Phosphorylation in Human Brain Biopsy Samples by Song, J, Combs, C.K, Pilcher, W.H, Song, L.Y, Utal, A.K, Coleman, P.D

“…A rapid reversible tau phosphorylation at Ser 396/404 was observed in adult human cortical biopsy tissue and rat primary cortical cell cultures. Tau…”
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Müller cell changes precede photoreceptor cell degeneration in the age-related retinal degeneration of the Fischer 344 rat by DiLoreto, David A., Martzen, Mark R., del Cerro, Constancia, Coleman, Paul D., del Cerro, Manuel

“…Previously, we have used descriptive pathology and histomorphometry, as well as functional testing to characterize the age-related retinal degeneration in the…”
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Reduced GAP-43 message levels are associated with increased neurofibrillary tangle density in the frontal association cortex (area 9) in Alzheimer's disease by Coleman, P D, Kazee, A M, Lapham, L, Eskin, T, Rogers, K

“…We previously suggested the hypothesis that defective neuronal plasticity is a major neurobiological deficit causing the dementia of Alzheimer's disease (AD)…”
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Divergence of biological and chronological aging: evidence from rodent studies by Collier, T J, Coleman, P D

“…Literature on aging populations of rodents supports the intuitive view that significant functional variation exists among like-aged, elderly individuals:…”
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