Search Results - "Coleman, K. G."

BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells by Sun, B, Fiskus, W, Qian, Y, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Saenz, D T, Mill, C P, Nowak, A J, Jain, N, Zhang, L, Wang, M, Khoury, J D, Coarfa, C, Crews, C M, Bhalla, K N

“…Bromodomain extraterminal protein (BETP) inhibitors transcriptionally repress oncoproteins and nuclear factor-κB (NF-κB) target genes that undermines the…”
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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells by Saenz, D T, Fiskus, W, Qian, Y, Manshouri, T, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Mill, C P, Sun, B, Qiu, P, Kadia, T M, Pemmaraju, N, DiNardo, C, Kim, M-S, Nowak, A J, Coarfa, C, Crews, C M, Verstovsek, S, Bhalla, K N

“…The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to…”
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Expression of engrailed proteins in arthropods, annelids, and chordates by Patel, N H, Martin-Blanco, E, Coleman, K G, Poole, S J, Ellis, M C, Kornberg, T B, Goodman, C S

“…engrailed is a homeobox gene that has an important role in Drosophila segmentation. Genes homologous to engrailed have been identified in several other…”
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta by Garofalo, R S, Orena, S J, Rafidi, K, Torchia, A J, Stock, J L, Hildebrandt, AL, Coskran, T, Black, S C, Brees, D J, Wicks, J R, McNeish, J D, Coleman, K G

“…The serine/threonine kinase Akt/PKB plays key roles in the regulation of cell growth, survival, and metabolism. It remains unclear, however, whether the…”
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The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene by Coleman, K G, Poole, S J, Weir, M P, Soeller, W C, Kornberg, T

“…The invected and engrailed genes are juxtaposed in the Drosophila genome and are closely related in sequence and pattern of expression. The structure of the…”
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Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene by Joyner, A L, Kornberg, T, Coleman, K G, Cox, D R, Martin, G R

“…Regions of the mouse and human genomes with strong homology to the Drosophila engrailed gene have been identified by Southern blot analysis. One mouse…”
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Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and characterization of the CDC24 gene and adjacent regions of the chromosome by Coleman, K G, Steensma, H Y, Kaback, D B, Pringle, J R

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The transcription unit of the Drosophila engrailed locus: an unusually small portion of a 70,000 bp gene by Drees, B., Ali, Z., Soeller, W. C., Coleman, K. G., Poole, S. J., Kornberg, T.

“…Transcripts from the engrailed gene of Drosophila melanogaster have been characterized by Northern, S1 nuclease sensitivity, and primer extension analyses. The…”
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Temperature-sensitive lethal mutations on yeast chromosome I appear to define only a small number of genes [Saccharomyces cerevisiae] by Kaback, David B, Oeller, Paul W, Steensma, H. Yde, Hirschman, Janet, Ruezinsky, Diane, Coleman, Kevin G, Pringle, John R

“…A method was developed for isolating large numbers of mutations on chromosome I of the yeast Saccharomyces cerevisiae. A strain monosomic for chromosome I…”
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The Genomic Organization and Polymorphism Analysis of the Human Niemann-Pick C1 Gene by Morris, Jill A., Zhang, Dana, Coleman, Katherine G., Nagle, James, Pentchev, Peter G., Carstea, Eugene D.

“…Niemann-Pick C (NP-C) is a fatal autosomal recessive storage disorder characterized by progressive neurodegeneration and variable hepatosplenomegaly. At the…”
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Identification of CDK4 Sequences Involved in Cyclin D1 and p16 Binding by Coleman, Kevin G., Wautlet, Barri Swain, Morrissey, David, Mulheron, Janet, Sedman, Sylvia A., Brinkley, Pamela, Price, Sandy, Webster, Kevin R.

“…Activation of CDK4 is regulated, in part, by its association with a D-type cyclin. Conversely, CDK4 activity is inhibited when it is bound to the…”
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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2 by Peng, Xiao-Ding, Xu, Pei-Zhang, Chen, Mei-Ling, Hahn-Windgassen, Annett, Skeen, Jennifer, Jacobs, Joel, Sundararajan, Deepa, Chen, William S, Crawford, Susan E, Coleman, Kevin G, Hay, Nissim

“…To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO)…”
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BET protein proteolysis targeting chimera by Jain, N, Zhang, L, Coarfa, C, Saenz, D T, Mill, C P, Crews, C M, Qian, Y, Raina, K, Nowak, A J, Rajapakshe, K, Coleman, K G, Wang, M, Shen, A, Fiskus, W, Khoury, J D, Sun, B, Crew, A P, Bhalla, K N

“…Bromodomain extraterminal protein (BETP) inhibitors transcriptionally repress oncoproteins and nuclear factor-[kappa]B (NF-[kappa]B) target genes that…”
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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor AML cells by Saenz, D T, Fiskus, W, Qian, Y, Manshouri, T, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Mill, C P, Sun, B, Qiu, P, Kadia, T M, Pemmaraju, N, DiNardo, C, Kim, M-S, Nowak, A J, Coarfa, C, Crews, C M, Verstovsek, S, Bhalla, K N

“…The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to…”
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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor by Coarfa, C, Saenz, D T, Manshouri, T, Mill, C P, Crews, C M, Qian, Y, Raina, K, Nowak, A J, Rajapakshe, K, Coleman, K G, DiNardo, C, Kim, M-S, Shen, A, Pemmaraju, N, Qiu, P, Kadia, T M, Fiskus, W, Sun, B, Verstovsek, S, Crew, A P, Bhalla, K N

“…The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to…”
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Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis by Carstea, Eugene D., Morris, Jill A., Coleman, Katherine G., Loftus, Stacie K., Zhang, Dana, Cummings, Christiano, Gu, Jessie, Rosenfeld, Melissa A., Pavan, William J., Krizman, David B., Nagle, James, Polymeropoulos, Mihail H., Sturley, Stephen L., Ioannou, Yiannis A., Higgins, Maureen E., Comly, Marcella, Cooney, Adele, Brown, Anthony, Kaneski, Christine R., Blanchette-Mackie, E. Joan, Dwyer, Nancy K., Neufeld, Edward B., Chang, Ta-Yuan, Liscum, Laura, Strauss, Jerome F., Ohno, Kousaku, Zeigler, Marsha, Carmi, Rivka, Sokol, Jacob, Markie, David, O'Neill, Raymond R., van Diggelen, O. P., Elleder, Milan, Patterson, Marc C., Brady, Roscoe O., Vanier, Marie T., Pentchev, Peter G., Tagle, Danilo A.

“…Niemann-Pick type C (NP-C) disease, a fatal neurovisceral disorder, is characterized by lysosomal accumulation of low density lipoprotein (LDL)-derived…”
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Substantial Narrowing of the Niemann-Pick C Candidate Interval by Yeast Artificial Chromosome Complementation by Gu, Jessie Z., Carstea, Eugene D., Cummings, Christiano, Morris, Jill A., Loftus, Stacie K., Zhang, Dana, Coleman, Katherine G., Cooney, Adele M., Comly, Marcy E., Fandino, Laura, Roff, Calvin, Tagle, Danilo A., Pavan, William J., Pentchev, Peter G., Rosenfeld, Melissa A.

“…Niemann-Pick disease type C (NP-C) is an autosomal recessive lipidosis linked to chromosome 18q11-12, characterized by lysosomal accumulation of unesterified…”
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The engrailed locus of Drosophila melanogaster: genetic, developmental, and molecular studies by Ali, Z, Drees, B, Coleman, K G, Gustavson, E, Karr, T L, Kauvar, L M, Poole, S J, Soeller, W, Weir, M P, Kornberg, T

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Abstract S4-03: Targeted and selective degradation of estrogen receptor (ER) alpha by PROTACs by Flanagan, JJ, Rossi, AK, Anderoli, M, Willard, RR, Gordon, D, Harling, J, Churcher, I, Smith, I, Zinn, N, Bantscheff, M, Crews, CM, Crew, A, Coleman, KG, Winkler, JD, Qian, Y

“…ERα-positive breast cancers comprise approximately 80% of all newly diagnosed cases. Current treatment approaches targeting ER signaling include antagonizing…”
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Commercial evolution of nanotechnology by Coleman, K.G.

“…Scientific & technological advancement is the primary factor to achieving sustainable economic growth. History has shown that breakthroughs in science that are…”
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