Search Results - "Coleman, Ilsa M."

LuCaP Prostate Cancer Patient‐Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an­­d Serve as Models for Evaluating Cancer Therapeutics by Nguyen, Holly M., Vessella, Robert L., Morrissey, Colm, Brown, Lisha G., Coleman, Ilsa M., Higano, Celestia S., Mostaghel, Elahe A., Zhang, Xiaotun, True, Lawrence D., Lam, Hung‐Ming, Roudier, Martine, Lange, Paul H., Nelson, Peter S., Corey, Eva

“…BACKGROUND Metastatic prostate cancer is a common and lethal disease for which there are no therapies that produce cures or long‐term durable remissions…”
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Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant by Sun, Shihua, Sprenger, Cynthia C T, Vessella, Robert L, Haugk, Kathleen, Soriano, Kathryn, Mostaghel, Elahe A, Page, Stephanie T, Coleman, Ilsa M, Nguyen, Holly M, Sun, Huiying, Nelson, Peter S, Plymate, Stephen R

“…Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling despite AR blockade. Recent…”
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SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer by Zhang, Xiaotun, Coleman, Ilsa M, Brown, Lisha G, True, Lawrence D, Kollath, Lori, Lucas, Jared M, Lam, Hung-Ming, Dumpit, Ruth, Corey, Eva, Chéry, Lisly, Lakely, Bryce, Higano, Celestia S, Montgomery, Bruce, Roudier, Martine, Lange, Paul H, Nelson, Peter S, Vessella, Robert L, Morrissey, Colm

“…The neuroendocrine phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize…”
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Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer by Lim, Yiting, Arora, Sonali, Schuster, Samantha L., Corey, Lukas, Fitzgibbon, Matthew, Wladyka, Cynthia L., Wu, Xiaoying, Coleman, Ilsa M., Delrow, Jeffrey J., Corey, Eva, True, Lawrence D., Nelson, Peter S., Ha, Gavin, Hsieh, Andrew C.

“…The functional consequences of genetic variants within 5’ untranslated regions (UTRs) on a genome-wide scale are poorly understood in disease. Here we develop…”
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A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models by Mamouni, Kenza, Zhang, Shumin, Li, Xin, Chen, Yanhua, Yang, Yang, Kim, Jaeah, Bartlett, Michael G., Coleman, Ilsa M., Nelson, Peter S., Kucuk, Omer, Wu, Daqing

“…The high prevalence and long latency period of prostate cancer (PCa) provide a unique opportunity to control disease progression with dietary and nutraceutical…”
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Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression : Therapeutic implications for castration-resistant prostate cancer by MOSTAGHEL, Elahe A, PAGE, Stephanie T, BREMNER, William J, GLEAVE, Martin E, NELSON, Peter S, LIN, Daniel W, FAZLI, Ladan, COLEMAN, Iisa M, TRUE, Lawrence D, KNUDSEN, Beatrice, HESS, David L, NELSON, Colleen C, MATSUMOTO, Alvin M

“…Androgen deprivation therapy (ADT) remains the primary treatment for advanced prostate cancer. The efficacy of ADT has not been rigorously evaluated by…”
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Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer by Glumac, Paige M, Gallant, Joseph P, Shapovalova, Mariya, Li, Yingming, Murugan, Paari, Gupta, Shilpa, Coleman, Ilsa M, Nelson, Peter S, Dehm, Scott M, LeBeau, Aaron M

“…Aggressive variant prostate cancer (AVPC) is a nonandrogen receptor-driven form of disease that arises in men in whom standard-of-care therapies have failed…”
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Cabozantinib can block growth of neuroendocrine prostate cancer patient-derived xenografts by disrupting tumor vasculature by Labrecque, Mark P, Brown, Lisha G, Coleman, Ilsa M, Nguyen, Holly M, Lin, Daniel W, Corey, Eva, Nelson, Peter S, Morrissey, Colm

“…With the advent of potent second-line anti-androgen therapy, we and others have observed an increased incidence of androgen receptor (AR)-null small cell or…”
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Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer by Isaacs, John T, Dalrymple, Susan L, Antony, Lizamma, Marc Rosen, David, Coleman, Ilsa M, Nelson, Peter S, Kostova, Maya, Murray, Iain A, Perdew, Gary H, Denmeade, Samuel R, Akinboye, Emmanuel S, Brennen, W Nathaniel

“…The quinoline-3-carboxamide, Tasquinimod (TasQ), is orally active as a maintenance therapy with an on-target mechanism-of-action via allosteric binding to…”
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Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4 by Coleman, Daniel J., Sampson, David A., Sehrawat, Archana, Kumaraswamy, Anbarasu, Sun, Duanchen, Wang, Yuzhuo, Schwartzman, Jacob, Urrutia, Joshua, Lee, Ahn R., Coleman, Ilsa M., Nelson, Peter S., Dong, Xuesen, Morrissey, Colm, Corey, Eva, Xia, Zheng, Yates, Joel A., Alumkal, Joshi J.

“…Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer. Importantly, our recent work examining metastatic biopsy samples…”
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The effects of aging on the molecular and cellular composition of the prostate microenvironment by Bianchi-Frias, Daniella, Vakar-Lopez, Funda, Coleman, Ilsa M, Plymate, Stephen R, Reed, May J, Nelson, Peter S

“…Advancing age is associated with substantial increases in the incidence rates of common diseases affecting the prostate gland including benign prostatic…”
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Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate by Pascal, Laura E, True, Lawrence D, Campbell, David S, Deutsch, Eric W, Risk, Michael, Coleman, Ilsa M, Eichner, Lillian J, Nelson, Peter S, Liu, Alvin Y

“…: Expression levels of mRNA and protein by cell types exhibit a range of correlations for different genes. In this study, we compared levels of mRNA abundance…”
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Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations by Bianchi-Frias, Daniella, Basom, Ryan, Delrow, Jeffrey J, Coleman, Ilsa M, Dakhova, Olga, Qu, Xiaoyu, Fang, Min, Franco, Omar E, Ericson, Nolan G, Bielas, Jason H, Hayward, Simon W, True, Lawrence, Morrissey, Colm, Brown, Lisha, Bhowmick, Neil A, Rowley, David, Ittmann, Michael, Nelson, Peter S

“…Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have…”
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Defining cellular population dynamics at single-cell resolution during prostate cancer progression by Germanos, Alexandre A, Arora, Sonali, Zheng, Ye, Goddard, Erica T, Coleman, Ilsa M, Ku, Anson T, Wilkinson, Scott, Song, Hanbing, Brady, Nicholas J, Amezquita, Robert A, Zager, Michael, Long, Annalysa, Yang, Yu Chi, Bielas, Jason H, Gottardo, Raphael, Rickman, David S, Huang, Franklin W, Ghajar, Cyrus M, Nelson, Peter S, Sowalsky, Adam G, Setty, Manu, Hsieh, Andrew C

“…Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of…”
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VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer by Goel, Hira Lal, Chang, Cheng, Pursell, Bryan, Leav, Irwin, Lyle, Stephen, Xi, Hualin Simon, Hsieh, Chung-Cheng, Adisetiyo, Helty, Roy-Burman, Pradip, Coleman, Ilsa M, Nelson, Peter S, Vessella, Robert L, Davis, Roger J, Plymate, Stephen R, Mercurio, Arthur M

“…We show that the VEGF receptor neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and that its expression in tumor cells is induced…”
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Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis by Sung, Shian-Ying, Hsieh, Chia-Ling, Law, Andrew, Zhau, Haiyen E, Pathak, Sen, Multani, Asha S, Lim, Sharon, Coleman, Ilsa M, Wu, Li-Chin, Figg, William D, Dahut, William L, Nelson, Peter, Lee, Jae K, Amin, Mahul B, Lyles, Robert, Johnstone, Peter A J, Marshall, Fray F, Chung, Leland W K

“…Human bone stromal cells, after three-dimensional coculture with human prostate cancer (PCa) cells in vitro, underwent permanent cytogenetic and gene…”
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Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer by Sayar, Erolcan, Patel, Radhika A, Coleman, Ilsa M, Roudier, Martine P, Zhang, Ailin, Mustafi, Pallabi, Low, Jin-Yih, Hanratty, Brian, Ang, Lisa S, Bhatia, Vipul, Adil, Mohamed, Bakbak, Hasim, Quigley, David A, Schweizer, Michael T, Hawley, Jessica E, Kollath, Lori, True, Lawrence D, Feng, Felix Y, Bander, Neil H, Corey, Eva, Lee, John K, Morrissey, Colm, Gulati, Roman, Nelson, Peter S, Haffner, Michael C

“…Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are limited data on the heterogeneity of PSMA tissue…”
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Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer by Brennen, W Nathaniel, Zhu, Yezi, Coleman, Ilsa M, Dalrymple, Susan L, Antony, Lizamma, Patel, Radhika A, Hanratty, Brian, Chikarmane, Roshan, Meeker, Alan K, Zheng, S Lilly, Hooper, Jody E, Luo, Jun, De Marzo, Angelo M, Corey, Eva, Xu, Jianfeng, Yegnasubramanian, Srinivasan, Haffner, Michael C, Nelson, Peter S, Nelson, William G, Isaacs, William B, Isaacs, John T

“…Resistance to AR signaling inhibitors (ARSis) in a subset of metastatic castration-resistant prostate cancers (mCRPCs) occurs with the emergence of AR-…”
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Influence of Surgical Manipulation on Prostate Gene Expression: Implications for Molecular Correlates of Treatment Effects and Disease Prognosis by LIN, Daniel W, COLEMAN, Lisa M, HAWLEY, Sarah, DUMPIT, Ruth, GIFFORD, David, KEZELE, Philip, HAU HUNG, KNUDSEN, Beatrice S, KRISTAL, Alan R, NELSON, Peter S

“…Measurements of tissue gene expression are increasingly used for disease stratification, clinical trial eligibility, and assessment of neoadjuvant therapy…”
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Tissue-specific consequences of cyclin D1 overexpression in prostate cancer progression by YUE HE, FRANCE, Omar E, MING JIANG, WILLIAMS, Karin, LOVE, Harold D, COLEMAN, Ilsa M, NELSON, Peter S, HAYWARD, Simon W

“…The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G(1)…”
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