Search Results - "Coleman, G"

Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes by McGuigan, Andrew, Kelly, Paul, Turkington, Richard C, Jones, Claire, Coleman, Helen G, McCain, R Stephen

“…This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that…”
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The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020 by Morgan, Eileen, Soerjomataram, Isabelle, Rumgay, Harriet, Coleman, Helen G., Thrift, Aaron P., Vignat, Jérôme, Laversanne, Mathieu, Ferlay, Jacques, Arnold, Melina

“…The aim of this study was to provide an overview of the burden of esophageal cancer in 185 countries in 2020 and projections for the year 2040. Estimates of…”
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Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7 by Coleman, Jr, Leon G, Zou, Jian, Crews, Fulton T

“…Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate…”
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ZINC: A Free Tool to Discover Chemistry for Biology by Irwin, John J, Sterling, Teague, Mysinger, Michael M, Bolstad, Erin S, Coleman, Ryan G

“…ZINC is a free public resource for ligand discovery. The database contains over twenty million commercially available molecules in biologically relevant…”
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Toll-like receptor signaling and stages of addiction by Crews, Fulton T., Walter, T. Jordan, Coleman, Leon G., Vetreno, Ryan P.

“…Background Athina Markou and her colleagues discovered persistent changes in adult behavior following adolescent exposure to ethanol or nicotine consistent…”
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QuPath: Open source software for digital pathology image analysis by Bankhead, Peter, Loughrey, Maurice B., Fernández, José A., Dombrowski, Yvonne, McArt, Darragh G., Dunne, Philip D., McQuaid, Stephen, Gray, Ronan T., Murray, Liam J., Coleman, Helen G., James, Jacqueline A., Salto-Tellez, Manuel, Hamilton, Peter W.

“…QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution for digital pathology and…”
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Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling by Coleman, Jr, Leon G, Zou, Jian, Crews, Fulton T

“…Microglia are critical mediators of neuroimmune pathology across multiple neurologic disorders. Microglia can be persistently activated or "primed" by…”
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Risk of Malignant Progression in Barrett's Esophagus Patients: Results from a Large Population-Based Study by Bhat, Shivaram, Coleman, Helen G., Yousef, Fouad, Johnston, Brian T., McManus, Damian T., Gavin, Anna T., Murray, Liam J.

“…Background Barrett's esophagus (BE) is a premalignant lesion that predisposes to esophageal adenocarcinoma. However, the reported incidence of esophageal…”
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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer by Raina, Kanak, Lu, Jing, Qian, Yimin, Altieri, Martha, Gordon, Deborah, Rossi, Ann Marie K., Wang, Jing, Chen, Xin, Dong, Hanqing, Siu, Kam, Winkler, James D., Crew, Andrew P., Crews, Craig M., Coleman, Kevin G.

“…Prostate cancer has the second highest incidence among cancers in men worldwide and is the second leading cause of cancer deaths of men in the United States…”
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The Epidemiology of Esophageal Adenocarcinoma by Coleman, Helen G., Xie, Shao-Hua, Lagergren, Jesper

“…The incidence of esophageal adenocarcinoma (EAC) has increased in many Western countries and is higher in men than women. Some risk factors for EAC have been…”
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Ligand pose and orientational sampling in molecular docking by Coleman, Ryan G, Carchia, Michael, Sterling, Teague, Irwin, John J, Shoichet, Brian K

“…Molecular docking remains an important tool for structure-based screening to find new ligands and chemical probes. As docking ambitions grow to include new…”
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Prognostic Value of Myocardial Scarring on CMR in Patients With Cardiac Sarcoidosis by Coleman, G. Cameron, MD, Shaw, Peter W., MD, Balfour, Pelbreton C., MD, ScM, Gonzalez, Jorge A., MD, Kramer, Christopher M., MD, Patel, Amit R., MD, Salerno, Michael, MD, PhD, MS

“…Abstract Objectives This study sought to perform a systematic review and meta-analysis to understand the prognostic value of myocardial scarring as evidenced…”
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RedDots: a temperate 1.5 Earth-mass planet candidate in a compact multiterrestrial planet system around GJ 1061 by Dreizler, S, Jeffers, S V, Rodríguez, E, Zechmeister, M, Barnes, J R, Haswell, C A, Coleman, G A L, Lalitha, S, Hidalgo Soto, D, Strachan, J B P, Hambsch, F-J, López-González, M J, Morales, N, Rodríguez López, C, Berdiñas, Z M, Ribas, I, Pallé, E, Reiners, A, Anglada-Escudé, G

“…ABSTRACT Small low-mass stars are favourable targets for the detection of rocky habitable planets. In particular, planetary systems in the solar neighbourhood…”
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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1 by Crew, Andrew P, Raina, Kanak, Dong, Hanqing, Qian, Yimin, Wang, Jing, Vigil, Dominico, Serebrenik, Yevgeniy V, Hamman, Brian D, Morgan, Alicia, Ferraro, Caterina, Siu, Kam, Neklesa, Taavi K, Winkler, James D, Coleman, Kevin G, Crews, Craig M

“…Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent…”
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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells by Saenz, D T, Fiskus, W, Qian, Y, Manshouri, T, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Mill, C P, Sun, B, Qiu, P, Kadia, T M, Pemmaraju, N, DiNardo, C, Kim, M-S, Nowak, A J, Coarfa, C, Crews, C M, Verstovsek, S, Bhalla, K N

“…The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to…”
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The role of neuroimmune signaling in alcoholism by Crews, Fulton T., Lawrimore, Colleen J., Walter, T. Jordan, Coleman, Leon G.

“…Alcohol consumption and stress increase brain levels of known innate immune signaling molecules. Microglia, the innate immune cells of the brain, and neurons…”
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PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation by Muvaffak, Asli, Coleman, Kevin G

“…Ataxia telangiectasia-mutated (ATM) kinase is a central regulator of the DNA damage response (DDR) signaling pathway, and its function is critical for the…”
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Dietary fiber intake and risk of colorectal cancer and incident and recurrent adenoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial by Kunzmann, Andrew T, Coleman, Helen G, Huang, Wen-Yi, Kitahara, Cari M, Cantwell, Marie M, Berndt, Sonja I

“…Dietary fiber has been associated with a reduced risk of colorectal cancer. However, it remains unclear at which stage in the carcinogenic pathway fiber may…”
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Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis by Doherty, Michelle T, Sanni, Omolara B, Coleman, Helen G, Cardwell, Chris R, McCluggage, W Glenn, Quinn, Declan, Wylie, James, McMenamin, Úna C

“…To inform treatment decisions in women diagnosed with endometrial hyperplasia, quantification of the potential for concurrent endometrial cancer and the future…”
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Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery by Fischer, Marcus, Coleman, Ryan G., Fraser, James S., Shoichet, Brian K.

“…Proteins fluctuate between alternative conformations, which presents a challenge for ligand discovery because such flexibility is difficult to treat…”
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