Search Results - "Cole, Timothy J"

Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants by Kanki, Monica, Nath, Artika P., Xiang, Ruidong, Yiallourou, Stephanie, Fuller, Peter J., Cole, Timothy J., Cánovas, Rodrigo, Young, Morag J.

“…Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings…”
Get full text

Trop2: From development to disease by McDougall, Annie R.A., Tolcos, Mary, Hooper, Stuart B., Cole, Timothy J., Wallace, Megan J.

“…Background: Trop2 was first discovered as a biomarker of invasive trophoblast cells. Since then most research has focused on its role in tumourigenesis because…”
Get full text

Minireview: Glucocorticoid Regulation of Lung Development: Lessons Learned From Conditional GR Knockout Mice by Bird, A. Daniel, McDougall, Annie R. A, Seow, Bennet, Hooper, Stuart B, Cole, Timothy J

“…Glucocorticoid (GC) steroid hormones have well-characterized roles in the regulation of systemic homeostasis, yet less understood is their known role in utero…”
Get full text

Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum by Jaumotte, Juliann D., Franks, Alexis L., Bargerstock, Erin M., Kisanga, Edwina Philip, Menden, Heather L., Ghersi, Alexis, Omar, Mahmoud, Wang, Liping, Rudine, Anthony, Short, Kelly L., Silswal, Neerupama, Cole, Timothy J., Sampath, Venkatesh, Monaghan-Nichols, A. Paula, DeFranco, Donald B.

“…Synthetic glucocorticoids (sGCs) such as dexamethasone (DEX), while used to mitigate inflammation and disease progression in premature infants with severe…”
Get full text

Glucocorticoids Antagonize Estrogens by Glucocorticoid Receptor-Mediated Activation of Estrogen Sulfotransferase by HAIBIAO GONG, JARZYNKA, Michael J, WEN XIE, COLE, Timothy J, JUNG HOON LEE, WADA, Taira, BIN ZHANG, JIE GAO, SONG, Wen-Chao, DEFRANCO, Donald B, CHENG, Shi-Yuan

“…Glucocorticoids and estrogens are two classes of steroid hormones that have essential but distinct physiologic functions. Estrogens also represent a risk…”
Get full text

Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs by Wallace, Megan J, Probyn, Megan E, Zahra, Valerie A, Crossley, Kelly, Cole, Timothy J, Davis, Peter G, Morley, Colin J, Hooper, Stuart B

“…Bronchopulmonary dysplasia (BPD) is closely associated with ventilator-induced lung injury (VILI) in very preterm infants. The greatest risk of VILI may be in…”
Get full text

Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung by McDougall, Annie R A, Fosang, Amanda J, Faggian, Jessica, Wallace, Megan J, Crossley, Kelly J, Cole, Timothy J, Hooper, Stuart B

“…Prenatal glucocorticoid treatment decreases alveolar tissue volumes and facilitates fetal lung maturation, however the mechanisms responsible are largely…”
Get full text

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis by Jurado, Sabine, Smyth, Ian, van Denderen, Bryce, Tenis, Nora, Hammet, Andrew, Hewitt, Kimberly, Ng, Jane-Lee, McNees, Carolyn J, Kozlov, Sergei V, Oka, Hayato, Kobayashi, Masahiko, Conlan, Lindus A, Cole, Timothy J, Yamamoto, Ken-Ichi, Taniguchi, Yoshihito, Takeda, Shunichi, Lavin, Martin F, Heierhorst, Jörg

“…Zn²(+)-finger proteins comprise one of the largest protein superfamilies with diverse biological functions. The ATM substrate Chk2-interacting Zn²(+)-finger…”
Get full text

The science of steroids by Cole, Timothy J., Short, Kelly L., Hooper, Stuart B.

“…Steroids are complex lipophilic molecules that have many actions in the body to regulate cellular, tissue and organ functions across the life-span. Steroid…”
Get full text

Matrix Metalloproteinase-3 Genotype Contributes to Age-Related Aortic Stiffening Through Modulation of Gene and Protein Expression by Medley, Tanya L, Kingwell, Bronwyn A, Gatzka, Christoph D, Pillay, Prakash, Cole, Timothy J

“…ABSTRACT—Matrix metalloproteinases (MMPs) include most major constituents of the arterial wall as substrates. A common promotor polymorphism (5A/6A) is…”
Get full text

cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells by Antony, Nisha, Weir, Jacqui R, McDougall, Annie R A, Mantamadiotis, Theo, Meikle, Peter J, Cole, Timothy J, Bird, Anthony D

“…Cyclic AMP Response Element-Binding Protein 1 (Creb1) is a transcription factor that mediates cyclic adenosine 3', 5'-monophosphate (cAMP) signalling in many…”
Get full text

Glucocorticoids Stimulate Hepatic and Renal Catecholamine Inactivation by Direct Rapid Induction of the Dopamine Sulfotransferase Sult1d1 by Wong, Stephen, Tan, Kheng, Carey, Kirstyn T, Fukushima, Atsushi, Tiganis, Tony, Cole, Timothy J

“…During the stress response and metabolic fasting, glucocorticoids acting via the glucocorticoid receptor (GR) stimulate hepatic glucose production by…”
Get full text

Mineralocorticoid Receptor Knockout Mice: Pathophysiology of Na+Metabolism by Berger, Stefan, Bleich, Markus, Schmid, Wolfgang, Cole, Timothy J., Peters, Jorg, Watanabe, Haruko, Kriz, Wilhelm, Warth, Richard, Greger, Rainer, Schutz, Gunther

“…Mineralocorticoid receptor (MR)-deficient mice were generated by gene targeting. These animals had a normal prenatal development. During the first week of…”
Get full text

Hard Palate Repair Timing and Facial Growth in Unilateral Cleft Lip and Palate: A Longitudinal Study by Liao, Yu-Fang, Cole, Timothy J., Mars, Michael

“…Objective: To investigate whether timing of hard palate repair had a significant effect on facial growth in patients with unilateral cleft lip and palate…”
Get full text

Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease by Caruana, Georgina, Farlie, Peter G, Hart, Adam H, Bagheri-Fam, Stefan, Wallace, Megan J, Dobbie, Michael S, Gordon, Christopher T, Miller, Kerry A, Whittle, Belinda, Abud, Helen E, Arkell, Ruth M, Cole, Timothy J, Harley, Vincent R, Smyth, Ian M, Bertram, John F

“…Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development…”
Get full text

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates by Bird, A Daniel, Greatorex, Spencer, Reser, David, Lavery, Gareth G, Cole, Timothy J

“…Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The…”
Get full text

Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development by Bird, Anthony D., Tan, Kheng H., Olsson, P. Fredrik, Zieba, Malgorzata, Flecknoe, Sharon J., Liddicoat, Douglas R., Mollard, Richard, Hooper, Stuart B., Cole, Timothy J.

“…Glucocorticoids play a vital role in fetal respiratory development and act via the intracellular glucocorticoid receptor (GR) to regulate transcription of key…”
Get full text

The Serum- and Glucocorticoid-Induced Kinase Is a Physiological Mediator of Aldosterone Action by Bhargava, Aditi, Fullerton, Meryl J., Myles, Kathy, Purdy, Timothy M., Funder, John W., Pearce, David, Cole, Timothy J.

“…Abstract Aldosterone plays a major role in regulating sodium and potassium flux in epithelial tissues such as kidney and colon. Recent evidence suggests that…”
Get full text

Mineralocorticoid receptor signalling in primary aldosteronism by Yang, Jun, Young, Morag J, Cole, Timothy J, Fuller, Peter J

“…Primary aldosteronism, or Conn syndrome, is the most common endocrine cause of hypertension. It is associated with a higher risk of cardiovascular, metabolic…”
Get full text

Impaired Cardiac Contractility Response to Hemodynamic Stress in S100A1-Deficient Mice by Du, Xiao-Jun, Cole, Timothy J., Tenis, Nora, Gao, Xiao-Ming, Köntgen, Frank, Kemp, Bruce E., Heierhorst, Jörg

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text