Search Results - "Cole, Suzanne"

Contribution of innate immune cells to pathogenesis of severe influenza virus infection by Cole, Suzanne L, Ho, Ling-Pei

“…Influenza A viruses (IAVs) cause respiratory illness of varying severity based on the virus strains, host predisposition and pre-existing immunity. Ultimately,…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis by Penkava, Frank, Velasco-Herrera, Martin Del Castillo, Young, Matthew D., Yager, Nicole, Nwosu, Lilian N., Pratt, Arthur G., Lara, Alicia Lledo, Guzzo, Charlotte, Maroof, Ash, Mamanova, Lira, Cole, Suzanne, Efremova, Mirjana, Simone, Davide, Filer, Andrew, Brown, Chrysothemis C., Croxford, Andrew L., Isaacs, John D., Teichmann, Sarah, Bowness, Paul, Behjati, Sam, Hussein Al-Mossawi, M.

“…Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis…”
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Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling by Cole, Suzanne, Murray, Janine, Simpson, Catherine, Okoye, Remi, Tyson, Kerry, Griffiths, Meryn, Baeten, Dominique, Shaw, Stevan, Maroof, Asher

“…IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains…”
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Hepcidin regulation by innate immune and infectious stimuli by Armitage, Andrew E., Eddowes, Lucy A., Gileadi, Uzi, Cole, Suzanne, Spottiswoode, Natasha, Selvakumar, Tharini Ashtalakshmi, Ho, Ling-Pei, Townsend, Alain R.M., Drakesmith, Hal

“…Hepcidin controls the levels and distribution of iron, an element whose availability can influence the outcome of infections. We investigated hepcidin…”
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Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus by Cole, Suzanne, Walsh, Alice, Yin, Xuefeng, Wechalekar, Mihir D, Smith, Malcolm D, Proudman, Susanna M, Veale, Douglas J, Fearon, Ursula, Pitzalis, Costantino, Humby, Frances, Bombardieri, Michele, Axel, Amy, Adams, 3rd, Homer, Chiu, Christopher, Sharp, Michael, Alvarez, John, Anderson, Ian, Madakamutil, Loui, Nagpal, Sunil, Guo, Yanxia

“…Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study…”
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Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression by Guo, Yanxia, Walsh, Alice M, Canavan, Mary, Wechalekar, Mihir D, Cole, Suzanne, Yin, Xuefeng, Scott, Brittney, Loza, Mathew, Orr, Carl, McGarry, Trudy, Bombardieri, Michele, Humby, Frances, Proudman, Susanna M, Pitzalis, Costantino, Smith, Malcolm D, Friedman, Joshua R, Anderson, Ian, Madakamutil, Loui, Veale, Douglas J, Fearon, Ursula, Nagpal, Sunil

“…Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab…”
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CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression by Guo, Yanxia, Walsh, Alice M, Fearon, Ursula, Smith, Malcolm D, Wechalekar, Mihir D, Yin, Xuefeng, Cole, Suzanne, Orr, Carl, McGarry, Trudy, Canavan, Mary, Kelly, Stephan, Lin, Tai-An, Liu, Xuejun, Proudman, Susanna M, Veale, Douglas J, Pitzalis, Costantino, Nagpal, Sunil

“…The inflammatory CD40-CD40L pathway is implicated in various autoimmune diseases, but the activity status of this pathway in various stages of rheumatoid…”
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Colorectal cancer metastases in thyroid: case report and literature review by Hussain, Syed Mohammad Asim, Cole, Suzanne, Hussain, Iram

“…The thyroid gland is an uncommon site for metastatic deposits from non-thyroid malignancies, occurring in only 1.4 - 3% of surgical specimens where malignancy…”
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CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis by Benamore, Rachel, Kendrick, Yvonne R, Repapi, Emmanouela, Helm, Emma, Cole, Suzanne L, Taylor, Stephen, Ho, Ling-Pei

“…A major gap in the management of sarcoidosis is the lack of accessible and objective methods to measure disease activity. Since 90% of patients have pulmonary…”
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M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza by Cole, Suzanne L, Dunning, Jake, Kok, Wai Ling, Benam, Kambez Hajipouran, Benlahrech, Adel, Repapi, Emmanouela, Martinez, Fernando O, Drumright, Lydia, Powell, Timothy J, Bennett, Michael, Elderfield, Ruth, Thomas, Catherine, Dong, Tao, McCauley, John, Liew, Foo Y, Taylor, Stephen, Zambon, Maria, Barclay, Wendy, Cerundolo, Vincenzo, Openshaw, Peter J, McMichael, Andrew J, Ho, Ling-Pei

“…In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better…”
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B Cell Heterogeneity in the Teleost Kidney: Evidence for a Maturation Gradient from Anterior to Posterior Kidney by Zwollo, Patty, Cole, Suzanne, Bromage, Erin, Kaattari, Stephen

“…The fish immune system is quite different from the mammalian system because the anterior kidney forms the main site for hematopoiesis in this species. Using…”
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Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection by Kok, Wai Ling, Denney, Laura, Benam, Kambez, Cole, Suzanne, Clelland, Colin, McMichael, Andrew J., Ho, Ling‐Pei

“…iNKT cells modulate severe influenza by reducing accumulation of inflammatory monocytes in lungs; possibly by targeting infected inflammatory monocytes for…”
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An Exploration of How Mexican American WIC Mothers Obtain Information About Behaviors Associated With Childhood Obesity Risk by Davis, Rachel E., PhD, Cole, Suzanne M., PhD, McKenney-Shubert, Shannon J., MPH, Jones, Sonya J., PhD, Peterson, Karen E., DSc

“…Abstract Objective To explore how a sample of Mexican American mothers with preschool-aged children recruited from a Midwestern Special Supplemental Nutrition…”
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Eat, play, view, sleep: Exploring Mexican American mothers' perceptions of decision making for four behaviors associated with childhood obesity risk by Davis, Rachel E., Cole, Suzanne M., Blake, Christine E., McKenney-Shubert, Shannon J., Peterson, Karen E.

“…This mixed methods study sought to understand who makes decisions about whether preschool-aged Mexican American children engage in eating, outdoor play, sleep,…”
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Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus by Fu, Tong-Ming, Wang, Dai, Freed, Daniel C, Tang, Aimin, Li, Fengsheng, He, Xi, Cole, Suzanne, Dubey, Sheri, Finnefrock, Adam C, ter Meulen, Jan, Shiver, John W, Casimiro, Danilo R

“…Highlights ► Early vaccines miss a pentameric gH complex important for viral epithelial entry. ► We restored expression of the complex in AD169 virus for…”
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Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs by Cornforth, Terri V, Moyo, Nathifa, Cole, Suzanne, Lam, Emily P S, Lobry, Tatiana, Wolchinsky, Ron, Lloyd, Angharad, Ward, Katarzyna, Denham, Eleanor M, Masi, Giulia, Qing Yun, Phyllis Tea, Moore, Colin, Dhaouadi, Selsabil, Besra, Gurdyal S, Veerapen, Natacha, Illing, Patricia T, Vivian, Julian P, Raynes, Jeremy M, Le Nours, Jérôme, Purcell, Anthony W, Kundu, Samit, Silk, Jonathan D, Williams, Luke, Papa, Sophie, Rossjohn, Jamie, Howie, Duncan, Dukes, Joseph

“…Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic…”
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The future of perioperative therapy in advanced renal cell carcinoma: how can we PROSPER? by Patel, Hiten D, Puligandla, Maneka, Shuch, Brian M, Leibovich, Bradley C, Kapoor, Anil, Master, Viraj A, Drake, Charles G, Heng, Daniel Yc, Lara, Primo N, Choueiri, Toni K, Maskens, Deborah, Singer, Eric A, Eggener, Scott E, Svatek, Robert S, Stadler, Walter M, Cole, Suzanne, Signoretti, Sabina, Gupta, Rajan T, Michaelson, Marc Dror, McDermott, David F, Cella, David, Wagner, Lynne I, Haas, Naomi B, Carducci, Michael A, Harshman, Lauren C, Allaf, Mohamad E

“…Patients with high-risk renal cell carcinoma (RCC) experience high rates of recurrence despite definitive surgical resection. Recent trials of adjuvant…”
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Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells by Cole, Suzanne L, Benam, Kambez H, McMichael, Andrew J, Ho, Ling-Pei

“…4-1BB is expressed on invariant (i)NKT cells, but its role is unclear. We showed previously that iNKT cells are involved in control of monocyte numbers during…”
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Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study by Li, Fusheng, Finnefrock, Adam C, Dubey, Sheri A, Korber, Bette T M, Szinger, James, Cole, Suzanne, McElrath, M Juliana, Shiver, John W, Casimiro, Danilo R, Corey, Lawrence, Self, Steven G

“…T cell directed HIV vaccines are based upon the induction of CD8+ T cell memory responses that would be effective in inhibiting infection and subsequent…”
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