Search Results - "Cole, Stewart T."

Who will develop new antibacterial agents? by Cole, Stewart T.

“…The golden age of antimicrobial drug development is a distant memory, and the likelihood of there being another seems slim. In part, this is because the…”
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Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis by HARTKOORN, Ruben C, UPLEKAR, Swapna, COLE, Stewart T

“…The antileprosy drug clofazimine is also of interest for the treatment of multidrug-resistant tuberculosis. To understand possible resistance mechanisms,…”
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Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1 by Wassermann, Ruth, Gulen, Muhammet F., Sala, Claudia, Perin, Sonia Garcia, Lou, Ye, Rybniker, Jan, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Hornung, Veit, Cole, Stewart T., Ablasser, Andrea

“…Cytosolic detection of microbial products is essential for the initiation of an innate immune response against intracellular pathogens such as Mycobacterium…”
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Tuberculosis drug discovery in the post‐post‐genomic era by Lechartier, Benoit, Rybniker, Jan, Zumla, Alimuddin, Cole, Stewart T

“…The expectation that genomics would result in new therapeutic interventions for infectious diseases remains unfulfilled. In the post‐genomic era, the decade…”
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In Vitro Combination Studies of Benzothiazinone Lead Compound BTZ043 against Mycobacterium tuberculosis by LECHARTIER, Benoit, HARTKOORN, Ruben C, COLE, Stewart T

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Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis by Singh, Pushpendra, Benjak, Andrej, Schuenemann, Verena J, Herbig, Alexander, Avanzi, Charlotte, Busso, Philippe, Nieselt, Kay, Krause, Johannes, Vera-Cabrera, Lucio, Cole, Stewart T

“…Mycobacterium lepromatosis is an uncultured human pathogen associated with diffuse lepromatous leprosy and a reactional state known as Lucio's phenomenon. By…”
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New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects by Zumla, Alimuddin I, Prof, Gillespie, Stephen H, Prof, Hoelscher, Michael, Prof, Philips, Patrick P J, PhD, Cole, Stewart T, Prof, Abubakar, Ibrahim, Prof, McHugh, Timothy D, Prof, Schito, Marco, PhD, Maeurer, Markus, Prof, Nunn, Andrew J, Prof

“…Summary About 1·3 million people died of tuberculosis in 2012, despite availability of effective drug treatment. Barriers to improvements in outcomes include…”
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Probable Zoonotic Leprosy in the Southern United States by Truman, Richard W, Singh, Pushpendra, Sharma, Rahul, Busso, Philippe, Rougemont, Jacques, Paniz-Mondolfi, Alberto, Kapopoulou, Adamandia, Brisse, Sylvain, Scollard, David M, Gillis, Thomas P, Cole, Stewart T

“…Mycobacterium leprae strains from armadillos and from patients in Louisiana with no foreign exposure were found to be highly similar genetically and different…”
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Towards a new combination therapy for tuberculosis with next generation benzothiazinones by Makarov, Vadim, Lechartier, Benoit, Zhang, Ming, Neres, João, van der Sar, Astrid M, Raadsen, Susanne A, Hartkoorn, Ruben C, Ryabova, Olga B, Vocat, Anthony, Decosterd, Laurent A, Widmer, Nicolas, Buclin, Thierry, Bitter, Wilbert, Andries, Koen, Pojer, Florence, Dyson, Paul J, Cole, Stewart T

“…The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo‐enzyme DprE1, decaprenylphosphoryl‐beta‐D‐ribose…”
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The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis by Solans, Luis, Gonzalo-Asensio, Jesús, Sala, Claudia, Benjak, Andrej, Uplekar, Swapna, Rougemont, Jacques, Guilhot, Christophe, Malaga, Wladimir, Martín, Carlos, Cole, Stewart T

“…The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes,…”
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Leprosy in wild chimpanzees by Hockings, Kimberley J., Mubemba, Benjamin, Avanzi, Charlotte, Pleh, Kamilla, Düx, Ariane, Bersacola, Elena, Bessa, Joana, Ramon, Marina, Metzger, Sonja, Patrono, Livia V., Jaffe, Jenny E., Benjak, Andrej, Bonneaud, Camille, Busso, Philippe, Couacy-Hymann, Emmanuel, Gado, Moussa, Gagneux, Sebastien, Johnson, Roch C., Kodio, Mamoudou, Lynton-Jenkins, Joshua, Morozova, Irina, Mätz-Rensing, Kerstin, Regalla, Aissa, Said, Abílio R., Schuenemann, Verena J., Sow, Samba O., Spencer, John S., Ulrich, Markus, Zoubi, Hyacinthe, Cole, Stewart T., Wittig, Roman M., Calvignac-Spencer, Sebastien, Leendertz, Fabian H.

“…Humans are considered as the main host for Mycobacterium leprae 1 , the aetiological agent of leprosy, but spillover has occurred to other mammals that are now…”
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Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein by Blasco, Benjamin, Chen, Jeffrey M, Hartkoorn, Ruben, Sala, Claudia, Uplekar, Swapna, Rougemont, Jacques, Pojer, Florence, Cole, Stewart T

“…The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional…”
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Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe by Schuenemann, Verena J, Avanzi, Charlotte, Krause-Kyora, Ben, Seitz, Alexander, Herbig, Alexander, Inskip, Sarah, Bonazzi, Marion, Reiter, Ella, Urban, Christian, Dangvard Pedersen, Dorthe, Taylor, G Michael, Singh, Pushpendra, Stewart, Graham R, Velemínský, Petr, Likovsky, Jakub, Marcsik, Antónia, Molnár, Erika, Pálfi, György, Mariotti, Valentina, Riga, Alessandro, Belcastro, M Giovanna, Boldsen, Jesper L, Nebel, Almut, Mays, Simon, Donoghue, Helen D, Zakrzewski, Sonia, Benjak, Andrej, Nieselt, Kay, Cole, Stewart T, Krause, Johannes

“…Studying ancient DNA allows us to retrace the evolutionary history of human pathogens, such as Mycobacterium leprae, the main causative agent of leprosy…”
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Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases by Li, Kai, Schurig-Briccio, Lici A, Feng, Xinxin, Upadhyay, Ashutosh, Pujari, Venugopal, Lechartier, Benoit, Fontes, Fabio L, Yang, Hongliang, Rao, Guodong, Zhu, Wei, Gulati, Anmol, No, Joo Hwan, Cintra, Giovana, Bogue, Shannon, Liu, Yi-Liang, Molohon, Katie, Orlean, Peter, Mitchell, Douglas A, Freitas-Junior, Lucio, Ren, Feifei, Sun, Hong, Jiang, Tong, Li, Yujie, Guo, Rey-Ting, Cole, Stewart T, Gennis, Robert B, Crick, Dean C, Oldfield, Eric

“…We report the discovery of a series of new drug leads that have potent activity against Mycobacterium tuberculosis as well as against other bacteria, fungi,…”
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Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase by Ahmed, Wareed, Sala, Claudia, Hegde, Shubhada R, Jha, Rajiv Kumar, Cole, Stewart T, Nagaraja, Valakunja

“…Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils…”
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Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis by MING ZHANG, SALA, Claudia, HARTKOORN, Ruben C, DHAR, Neeraj, MENDOZA-LOSANA, Alfonso, COLE, Stewart T

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Zoonotic Leprosy in the Southeastern United States by Sharma, Rahul, Singh, Pushpendra, Loughry, W J, Lockhart, J Mitchell, Inman, W Barry, Duthie, Malcolm S, Pena, Maria T, Marcos, Luis A, Scollard, David M, Cole, Stewart T, Truman, Richard W

“…Nine-banded armadillos (Dasypus novemcinctus) are naturally infected with Mycobacterium leprae and have been implicated in zoonotic transmission of leprosy…”
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Comparison of target enrichment strategies for ancient pathogen DNA by Furtwängler, Anja, Neukamm, Judith, Böhme, Lisa, Reiter, Ella, Vollstedt, Melanie, Arora, Natasha, Singh, Pushpendra, Cole, Stewart T, Knauf, Sascha, Calvignac-Spencer, Sébastien, Krause-Kyora, Ben, Krause, Johannes, Schuenemann, Verena J, Herbig, Alexander

“…In ancient DNA research, the degraded nature of the samples generally results in poor yields of highly fragmented DNA; targeted DNA enrichment is thus required…”
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Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis by Sala, Claudia, Dhar, Neeraj, Hartkoorn, Ruben C, Zhang, Ming, Ha, Young Hwan, Schneider, Patricia, Cole, Stewart T

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Comparative genomic and phylogeographic analysis of Mycobacterium leprae by Zidane, Nora, Macdonald, Murdo, Busso, Philippe, Stefani, Mariane M, Monot, Marc, Matsuoka, Masanori, Khamispour, Ali, Taylor, G Michael, Mays, Simon, Singh, Pushpendra, Dowlati, Yahya, Lockwood, Diana, Banu, Sayera, Sherafi, Diana, Harshman, Keith, Gattiker, Alexandre, Jianping, Shen, Watson, Claire, Rea, Thomas H, Thomas, Jérôme, Rougemont, Jacques, Cole, Stewart T, Donoghue, Helen D, Brennan, Patrick J, Honoré, Nadine, Paniz-Mondolfi, Alberto, Vera-Cabrera, Lucio, Spencer, John S, Bouwman, Abi, Garnier, Thierry, Sapkota, Bishwa Raj

“…Stewart Cole and colleagues report the genome sequence and comparative analyses of Brazilian, Indian, North American and Thai strains of Mycobacterium leprae ,…”
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