Search Results - "Cole, Serena L"

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins by Colca, Jerry R, McDonald, William G, Cavey, Gregory S, Cole, Serena L, Holewa, Danielle D, Brightwell-Conrad, Angela S, Wolfe, Cindy L, Wheeler, Jean S, Coulter, Kristin R, Kilkuskie, Peter M, Gracheva, Elena, Korshunova, Yulia, Trusgnich, Michelle, Karr, Robert, Wiley, Sandra E, Divakaruni, Ajit S, Murphy, Anne N, Vigueira, Patrick A, Finck, Brian N, Kletzien, Rolf F

“…Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have…”
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Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion by Vigueira, Patrick A., McCommis, Kyle S., Schweitzer, George G., Remedi, Maria S., Chambers, Kari T., Fu, Xiaorong, McDonald, William G., Cole, Serena L., Colca, Jerry R., Kletzien, Rolf F., Burgess, Shawn C., Finck, Brian N.

“…Carrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism…”
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1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition by Li, Linsen, Okumu, Antony A, Nolan, Sheri, English, Anthony, Vibhute, Sandip, Lu, Yanran, Hervert-Thomas, Katherine, Seffernick, Justin T, Azap, Lovette, Cole, Serena L, Shinabarger, D, Koeth, Laura M, Lindert, Steffen, Yalowich, Jack C, Wozniak, Daniel J, Mitton-Fry, Mark J

“…The development of new therapies to treat methicillin-resistant Staphylococcus aureus (MRSA) is needed to counteract the significant threat that MRSA presents…”
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The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism by Vigueira, Patrick A., McCommis, Kyle S., Hodges, Wesley T., Schweitzer, George G., Cole, Serena L., Oonthonpan, Lalita, Taylor, Eric B., McDonald, William G., Kletzien, Rolf F., Colca, Jerry R., Finck, Brian N.

“…New Findings What is the central question of this study? The antidiabetic effects of thiazolidinedione (TZD) drugs may be mediated in part by a molecular…”
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Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers by Colca, Jerry R, McDonald, William G, Cavey, Gregory S, Cole, Serena L, Holewa, Danielle D, Brightwell-Conrad, Angela S, Wolfe, Cindy L, Wheeler, Jean S, Coulter, Kristin R, Kilkuskie, Peter M, Gracheva, Elena, Korshunova, Yulia, Trusgnich, Michelle, Karr, Robert, Wiley, Sandra E, Divakaruni, Ajit S, Murphy, Anne N, Vigueira, Patrick A, Finck, Brian N, Kletzien, Rolf F

“…Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have…”
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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors by Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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A Human Respiratory Syncytial Virus (RSV) Primate Model of Enhanced Pulmonary Pathology Induced with a Formalin-Inactivated RSV Vaccine but Not a Recombinant FG Subunit Vaccine by Kakuk, Thomas J., Soike, Kenneth, Brideau, Roger J., Zaya, Renee M., Cole, Serena L., Zhang, J.-Y., Roberts, E. Donald, Wells, Peter A., Wathen, Michael W.

“…Human respiratory syncytial virus (RSV) is the leading cause of severe bronchiolitis and pneumonia in infants. RSV vaccine development has been stifled for the…”
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Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors by Skulnick, Harvey I, Johnson, Paul D, Howe, W. Jeffrey, Tomich, Paul K, Chong, Kong-Teck, Watenpaugh, Keith D, Janakiraman, Musiri N, Dolak, Lester A, McGrath, James P

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Vaccination of Cotton Rats with a Chimeric FG Glycoprotein of Human Respiratory Syncytial Virus Induces Minimal Pulmonary Pathology on Challenge by Wathen, Michael W., Kakuk, Thomas J., Brideau, Roger J., Hausknecht, Edward C., Cole, Serena L., Zaya, Renee M.

“…The cotton rat modelof human respiratory syncytial virus (RSV) infectionwasused to study the safety and efficacy of a chimeric FG glycoprotein that was…”
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Precipitation of the renin inhibitor ditekiren upon iv infusion; in vitro studies and their relationship to in vivo precipitation in the cynomolgus monkey by DAVIO, S. R, MCSHANE, M. M, KAKUK, T. J, ZAYA, R. M, COLE, S. L

“…Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug involved continuous i.v…”
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