Search Results - "Cole, Sarah L."

The Alzheimer's disease beta-secretase enzyme, BACE1 by Cole, Sarah L, Vassar, Robert

“…The pathogenesis of Alzheimer's disease is highly complex. While several pathologies characterize this disease, amyloid plaques, composed of the beta-amyloid…”
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Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1 by Liu, Qiang, Zerbinatti, Celina V., Zhang, Juan, Hoe, Hyang-Sook, Wang, Baiping, Cole, Sarah L., Herz, Joachim, Muglia, Louis, Bu, Guojun

“…Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease (AD), but the only genetic risk factor for late-onset AD is the ɛ4…”
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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice by Ohno, Masuo, Cole, Sarah L, Yasvoina, Marina, Zhao, Jie, Citron, Martin, Berry, Robert, Disterhoft, John F, Vassar, Robert

“…Abstract Evidence suggests that β-amyloid (Aβ) peptide triggers a pathogenic cascade leading to neuronal loss in Alzheimer’s disease (AD). However, the causal…”
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The oDGal Mouse: A Novel, Physiologically Relevant Rodent Model of Sporadic Alzheimer's Disease by Chadwick, Wayne, Maudsley, Stuart, Hull, William, Havolli, Enes, Boshoff, Eugene, Hill, Mark D W, Goetghebeur, Pascal J D, Harrison, David C, Nizami, Sohaib, Bedford, David C, Coope, Gareth, Real, Katia, Thiemermann, Christoph, Maycox, Peter, Carlton, Mark, Cole, Sarah L

“…Sporadic Alzheimer's disease (sAD) represents a serious and growing worldwide economic and healthcare burden. Almost 95% of current AD patients are associated…”
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The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology by Cole, Sarah L., Vassar, Robert

“…Amyloid plaques, composed of the amyloid β-protein (Aβ), are hallmark neuropathological lesions in Alzheimer disease (AD) brain. Aβ fulfills a central role in…”
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Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation by Oakley, Holly, Cole, Sarah L, Logan, Sreemathi, Maus, Erika, Shao, Pei, Craft, Jeffery, Guillozet-Bongaarts, Angela, Ohno, Masuo, Disterhoft, John, Van Eldik, Linda, Berry, Robert, Vassar, Robert

“…Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of beta-amyloid 42 (Abeta42) and cause familial…”
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Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level by Sadleir, Katherine R, Eimer, William A, Cole, Sarah L, Vassar, Robert

“…The β-secretase, BACE1, cleaves APP to initiate generation of the β-amyloid peptide, Aβ, that comprises amyloid plaques in Alzheimer's disease (AD). Reducing…”
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Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis by O'Connor, Tracy, Sadleir, Katherine R., Maus, Erika, Velliquette, Rodney A., Zhao, Jie, Cole, Sarah L., Eimer, William A., Hitt, Brian, Bembinster, Leslie A., Lammich, Sven, Lichtenthaler, Stefan F., Hébert, Sébastien S., De Strooper, Bart, Haass, Christian, Bennett, David A., Vassar, Robert

“…β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for β-amyloid (Aβ) production, is elevated in Alzheimer's disease (AD). Here, we show that…”
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Linking vascular disorders and Alzheimer's disease: Potential involvement of BACE1 by Cole, Sarah L, Vassar, Robert

“…Abstract The etiology of Alzheimer's disease (AD) remains unknown. However, specific risk factors have been identified, and aging is the strongest AD risk…”
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BACE1 structure and function in health and Alzheimer's disease by Cole, Sarah L, Vassar, Robert

“…Amyloid plaques, hallmark neuropathological lesions in Alzheimer's disease (AD) brain, are composed of the beta-amyloid peptide (Abeta). Much evidence suggests…”
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The effect of aldehyde structure on pyrolysis reactions by Sias, Eric R., Cole, Sarah L., Warner, Brian J., Wright, Emily M., McCunn, Laura R.

“…•Pyrolysis products of isovaleraldehyde and pivaldehyde are identified.•Aldehydes with branched alkyl groups decompose similarly to unbranched…”
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Statins Cause Intracellular Accumulation of Amyloid Precursor Protein, β-Secretase-cleaved Fragments, and Amyloid β-Peptide via an Isoprenoid-dependent Mechanism by Cole, Sarah L., Grudzien, Aneta, Manhart, Ingrid O., Kelly, Brent L., Oakley, Holly, Vassar, Robert

“…The use of statins, 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors that block the synthesis of mevalonate (and downstream products such as cholesterol and…”
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The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology by Sarah L. Cole, Robert Vassar

“…Amyloid plaques, composed of the amyloid β-protein (Aβ), are hallmark neuropathological lesions in Alzheimer disease (AD) brain. Aβ fulfills a central role…”
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B27 Abnormal bioenergetics in inclusion-containing mutant HTT exon 1 primary human neurons by Wood-Kaczmar, Alison, Ghosh, Rhia, Kriston-Vizi, Janos, Smith, Edward J, Chadwick, Wayne, Hargreaves, Iain P, Heales, Simon J, Abramov, Andrey Y, Cole, Sarah L, Ketteler, Robin, Bates, Gillian P, Andre, Ralph, Tabrizi, Sarah J

“…BackgroundMitochondrial dysfunction is a known component of HD pathogenesis, but the precise mechanisms and temporal order of events linked to mHTT inclusion…”
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A[beta] reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level by Sadleir, Katherine R, Eimer, William A, Cole, Sarah L, Vassar, Robert

“…Background The [beta]-secretase, BACE1, cleaves APP to initiate generation of the [beta]-amyloid peptide, A[beta], that comprises amyloid plaques in…”
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Phosphorylation of the Translation Initiation Factor eIF2[alpha] Increases BACE1 Levels and Promotes Amyloidogenesis by O'Connor, Tracy, Sadleir, Katherine R, Maus, Erika, Velliquette, Rodney A, Zhao, Jie, Cole, Sarah L, Eimer, William A, Hitt, Brian, Bembinster, Leslie A, Lammich, Sven, Lichtenthaler, Stefan F, Hébert, Sébastien S, De Strooper, Bart, Haass, Christian, Bennett, David A, Vassar, Robert

“…β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for β-amyloid (Aβ) production, is elevated in Alzheimer's disease (AD). Here, we show that…”
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Article: Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1 by Liu, Qiang, Zerbinatti, Celina V, Zhang, Juan, Hoe, Hyang-Sook, Wang, Baiping, Cole, Sarah L, Herz, Joachim, Muglia, Louis, Bu, Guojun

“…Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease (AD), but the only genetic risk factor for late-onset AD is the 4 allele…”
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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mic by Ohno, Masuo, Cole, Sarah L., Yasvoina, Marina, Zhao, Jie, Citron, Martin, Berry, Robert, Disterhoft, John F., Vassar, Robert

“…Evidence suggests that β-amyloid (Aβ) peptide triggers a pathogenic cascade leading to neuronal loss in Alzheimer’s disease (AD). However, the causal link…”
Get full text

Statins Cause Intracellular Accumulation of Amyloid Precursor Protein, β-Secretase-cleaved Fragments, and Amyloid β-Peptide via an Isoprenoid-dependent Mechanism by Sarah L. Cole, Aneta Grudzien, Ingrid O. Manhart, Brent L. Kelly, Holly Oakley, Robert Vassar

“…The use of statins, 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors that block the synthesis of mevalonate (and downstream products such as cholesterol and…”
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The play & the playwriting experience: An examination of creative process by Cole, Sarah L

“…This dissertation utilizes an interdisciplinary approach to examine both a playwright's creative product and process. It explores the question: "What did the…”
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