Search Results - "Cole, Robert. N"

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1 by Luo, Weibo, Hu, Hongxia, Chang, Ryan, Zhong, Jun, Knabel, Matthew, O'Meally, Robert, Cole, Robert N., Pandey, Akhilesh, Semenza, Gregg L.

“…The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells…”
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HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia by Yang, Yongkang, Lu, Haiquan, Chen, Chelsey, Lyu, Yajing, Cole, Robert N., Semenza, Gregg L.

“…Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a regulator of oxygen (O 2 ) homeostasis in metazoan species by binding to hypoxia…”
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Detecting significant changes in protein abundance by Kammers, Kai, Cole, Robert N., Tiengwe, Calvin, Ruczinski, Ingo

“…[Display omitted] •We review empirical Bayes methods for genomics and proteomics.•We show these methods have more power to detect changes in protein…”
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Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK) by Cao, Jia, Meng, Shumei, Chang, Evan, Beckwith-Fickas, Katherine, Xiong, Lishou, Cole, Robert N., Radovick, Sally, Wondisford, Fredric E., He, Ling

“…Metformin is a first-line antidiabetic agent taken by 150 million people across the world every year, yet its mechanism remains only partially understood and…”
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The role of N-terminal phosphorylation of DGK-θ by Barbernitz, Millie X., Devine, Lauren R., Cole, Robert N., Raben, Daniel M.

“…Diacylglycerol kinases (DGKs) are lipid kinases that mediate the phosphorylation of diacylglycerol (DAG) leading to the production of phosphatidic acid…”
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Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation by Liu, Xi, Abraham, John M., Cheng, Yulan, Wang, Zhixiong, Wang, Zhe, Zhang, Guanjun, Ashktorab, Hassan, Smoot, Duane T., Cole, Robert N., Boronina, Tatiana N., DeVine, Lauren R., Talbot, C. Conover, Liu, Zhengwen, Meltzer, Stephen J.

“…MicroRNA (miR) sponges containing miR binding sequences constitute a potentially powerful molecular therapeutic strategy. Recently, naturally occurring…”
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A Comprehensive Map of the Human Urinary Proteome by Marimuthu, Arivusudar, O’Meally, Robert. N, Chaerkady, Raghothama, Subbannayya, Yashwanth, Nanjappa, Vishalakshi, Kumar, Praveen, Kelkar, Dhanashree S, Pinto, Sneha M, Sharma, Rakesh, Renuse, Santosh, Goel, Renu, Christopher, Rita, Delanghe, Bernard, Cole, Robert. N, Harsha, H. C, Pandey, Akhilesh

“…The study of the human urinary proteome has the potential to offer significant insights into normal physiology as well as disease pathology. The information…”
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Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain by Washington-Hughes, Clorissa L, Roy, Shubhrajit, Seneviratne, Herana Kamal, Karuppagounder, Senthilkumar S, Morel, Yulemni, Jones, Jace W, Zak, Alex, Xiao, Tong, Boronina, Tatiana N, Cole, Robert N, Bumpus, Namandjé N, Chang, Christopher J, Dawson, Ted M, Lutsenko, Svetlana

“…Copper (Cu) has a multifaceted role in brain development, function, and metabolism. Two homologous Cu transporters, Atp7a (Menkes disease protein) and Atp7b…”
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Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1 by Bullen, John W, Tchernyshyov, Irina, Holewinski, Ronald J, DeVine, Lauren, Wu, Fan, Venkatraman, Vidya, Kass, David L, Cole, Robert N, Van Eyk, Jennifer, Semenza, Gregg L

“…Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that enable cells to adapt to reduced O2 availability. Proteins…”
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Proteomic changes in the hippocampus of large mammals after total-body low dose radiation by Iacono, Diego, Hatch, Kathleen, Murphy, Erin K, Post, Jeremy, Cole, Robert N, Perl, Daniel P, Day, Regina M

“…There is a growing interest in low dose radiation (LDR) to counteract neurodegeneration. However, LDR effects on normal brain have not been completely explored…”
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The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization by Rhoads, Shannon N, Monahan, Zachary T, Yee, Debra S, Leung, Andrew Y, Newcombe, Cameron G, O'Meally, Robert N, Cole, Robert N, Shewmaker, Frank P

“…FUS (fused in sarcoma) is an abundant, predominantly nuclear protein involved in RNA processing. Under various conditions, FUS functionally associates with RNA…”
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Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases by Welsh, Robin A, Song, Nianbin, Foss, Catherine A, Boronina, Tatiana, Cole, Robert N, Sadegh-Nasseri, Scheherazade

“…DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in…”
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Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle by Ramirez-Correa, Genaro A, Ma, Junfeng, Slawson, Chad, Zeidan, Quira, Lugo-Fagundo, Nahyr S, Xu, Mingguo, Shen, Xiaoxu, Gao, Wei Dong, Caceres, Viviane, Chakir, Khalid, DeVine, Lauren, Cole, Robert N, Marchionni, Luigi, Paolocci, Nazareno, Hart, Gerald W, Murphy, Anne M

“…Contractile dysfunction and increased deposition of O-linked β-N-acetyl-d-glucosamine (O-GlcNAc) in cardiac proteins are a hallmark of the diabetic heart…”
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Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis by Ratovitski, Tamara, Chighladze, Ekaterine, Arbez, Nicolas, Boronina, Tatiana, Herbrich, Shelley, Cole, Robert N., Ross, Christopher A.

“…Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a…”
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Proteomic Analysis of Chinese Hamster Ovary Cells by Baycin-Hizal, Deniz, Tabb, David L, Chaerkady, Raghothama, Chen, Lily, Lewis, Nathan E, Nagarajan, Harish, Sarkaria, Vishaldeep, Kumar, Amit, Wolozny, Daniel, Colao, Joe, Jacobson, Elena, Tian, Yuan, O’Meally, Robert N, Krag, Sharon S, Cole, Robert N, Palsson, Bernhard O, Zhang, Hui, Betenbaugh, Michael

“…To complement the recent genomic sequencing of Chinese hamster ovary (CHO) cells, proteomic analysis was performed on CHO cells including the cellular…”
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The cardiac acetyl-lysine proteome by Foster, D Brian, Liu, Ting, Rucker, Jasma, O'Meally, Robert N, Devine, Lauren R, Cole, Robert N, O'Rourke, Brian

“…In the heart, lysine acetylation has been implicated in processes ranging from transcriptional control of pathological remodeling, to cardioprotection arising…”
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Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity by Watkin, Erin E, Arbez, Nicolas, Waldron-Roby, Elaine, O'Meally, Robert, Ratovitski, Tamara, Cole, Robert N, Ross, Christopher A

“…Phosphorylation has been shown to have a significant impact on expanded huntingtin-mediated cellular toxicity. Several phosphorylation sites have been…”
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Assessing Amide Proton Transfer (APT) MRI Contrast Origins in 9 L Gliosarcoma in the Rat Brain Using Proteomic Analysis by Yan, Kun, Fu, Zongming, Yang, Chen, Zhang, Kai, Jiang, Shanshan, Lee, Dong-Hoon, Heo, Hye-Young, Zhang, Yi, Cole, Robert N., Van Eyk, Jennifer E., Zhou, Jinyuan

“…Purpose To investigate the biochemical origin of the amide photon transfer (APT)-weighted hyperintensity in brain tumors. Procedures Seven 9 L…”
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Electrophilic tuning of the chemoprotective natural product sulforaphane by Ahn, Young-Hoon, Hwang, Yousang, Liu, Hua, Wang, Xiu Jun, Zhang, Ying, Stephenson, Katherine K, Boronina, Tatiana N, Cole, Robert N, Dinkova-Kostova, Albena T, Talalay, Paul, Cole, Philip A

“…Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)butane], a naturally occurring isothiocyanate derived from cruciferous vegetables, is a highly potent inducer…”
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Statistical Inference from Multiple iTRAQ Experiments without Using Common Reference Standards by Herbrich, Shelley M, Cole, Robert N, West, Keith P, Schulze, Kerry, Yager, James D, Groopman, John D, Christian, Parul, Wu, Lee, O’Meally, Robert N, May, Damon H, McIntosh, Martin W, Ruczinski, Ingo

“…Isobaric tags for relative and absolute quantitation (iTRAQ) is a prominent mass spectrometry technology for protein identification and quantification that is…”
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