Search Results - "Cole, R. N."

Sir2-Dependent Activation of Acetyl-CoA Synthetase by Deacetylation of Active Lysine by Starai, V. J., Celic, I., Cole, R. N., Boeke, J. D., Escalante-Semerena, J. C.

“…Acetyl-coenzyme A (CoA) synthetase (Acs) is an enzyme central to metabolism in prokaryotes and eukaryotes. Acs synthesizes acetyl CoA from acetate, adenosine…”
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Patient autoantibodies deplete postsynaptic muscle‐specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice by Cole, R. N., Ghazanfari, N., Ngo, S. T., Gervásio, O. L., Reddel, S. W., Phillips, W. D.

“…The postsynaptic muscle‐specific kinase (MuSK) coordinates formation of the neuromuscular junction (NMJ) during embryonic development. Here we have studied the…”
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Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation by Zhang, Y, Dayalan Naidu, S, Samarasinghe, K, Van Hecke, G C, Pheely, A, Boronina, T N, Cole, R N, Benjamin, I J, Cole, P A, Ahn, Y-H, Dinkova-Kostova, A T

“…Background: Heat shock protein 90 (HSP90) has a key role in the maintenance of the cellular proteostasis. However, HSP90 is also involved in stabilisation of…”
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Maternal serum proteome changes between the first and third trimester of pregnancy in rural Southern Nepal by Scholl, P.F, Cole, R.N, Ruczinski, I, Gucek, M, Diez, R, Rennie, A, Nathasingh, C, Schulze, K, Christian, P, Yager, J.D, Groopman, J.D, West, K.P

“…Abstract Characterization of normal changes in the serum proteome during pregnancy may enhance understanding of maternal physiology and lead to the development…”
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Alternative O-Glycosylation/O-Phosphorylation of the Murine Estrogen Receptor β by Cheng, Xiaogang, Cole, Robert N, Zaia, Joseph, Hart, Gerald W

“…Estrogen receptor β, a homologue to estrogen receptor α, is a new member of the steroid hormone receptor family. Recently, we documented that estrogen receptor…”
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RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma by Wilky, B A, Kim, C, McCarty, G, Montgomery, E A, Kammers, K, DeVine, L R, Cole, R N, Raman, V, Loeb, D M

“…RNA helicase DDX3 has oncogenic activity in breast and lung cancers and is required for translation of complex mRNA transcripts, including those encoding key…”
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Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles by Donowitz, M, Singh, S, Singh, P, Salahuddin, F F, Chen, Y, Chakraborty, M, Murtazina, R, Gucek, M, Cole, R N, Zachos, N C, Kovbasnjuk, O, Broere, N, Smalley-Freed, W G, Reynolds, A B, Hubbard, A L, Seidler, U, Weinman, E, de Jonge, H R, Hogema, B M, Li, X

“…Na/H exchanger regulatory factor 1 (NHERF1) is a scaffold protein made up of two PDZ domains and an ERM binding domain. It is in the brush border of multiple…”
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Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles by Donowitz, M, Singh, S, Singh, P, Chakraborty, M, Chen, Y, Murtazina, R, Gucek, M, Cole, R N, Zachos, N C, Salahuddin, F F, Kovbasnjuk, O, Broere, N, Smalley-Freed, W G, Reynolds, A B, Hubbard, A L, Seidler, U, Weinman, E, de Jonge, H R, Hogema, B M, Li, X

“…To identify additional potential functions for the multi-PDZ domain containing protein Na+/H+ exchanger regulatory factor 2 (NHERF2), which is present in the…”
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Glycosylation sites flank phosphorylation sites on Synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating Synapsin I interactions by COLE, R. N, HART, G. W

“…Synapsin I is concentrated in nerve terminals, where it appears to anchor synaptic vesicles to the cytoskeleton and thereby ensures a steady supply of…”
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The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency by Baumgartner, M R, Almashanu, S, Suormala, T, Obie, C, Cole, R N, Packman, S, Baumgartner, E R, Valle, D

“…Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase (MCC) deficiency is an autosomal recessive disorder of leucine catabolism that appears to be the…”
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Direct Evidence That Sulfhydryl Groups of Keap1 Are the Sensors Regulating Induction of Phase 2 Enzymes That Protect against Carcinogens and Oxidants by Dinkova-Kostova, Albena T., Holtzclaw, W. David, Cole, Robert N., Itoh, Ken, Wakabayashi, Nobunao, Katoh, Yasutake, Yamamoto, Masayuki, Talalay, Paul

“…Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants…”
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Mapping Sites of O-GlcNAc Modification Using Affinity Tags for Serine and Threonine Post-translational Modifications by Wells, Lance, Vosseller, Keith, Cole, Robert N, Cronshaw, Janet M, Matunis, Michael J, Hart, Gerald W

“…Identifying sites of post-translational modifications on proteins is a major challenge in proteomics. O- Linked β- N -acetylglucosamine ( O -GlcNAc) is a…”
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Cytosolic O‐glycosylation is abundant in nerve terminals by Cole, Robert N., Hart, Gerald W.

“…Phosphorylation plays a key role in regulating growth cone migration and protein trafficking in nerve terminals. Here we show that nerve terminal proteins…”
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O-linked N-acetylglucosamine: the "yin-yang" of Ser/Thr phosphorylation? Nuclear and cytoplasmic glycosylation by Hart, G W, Greis, K D, Dong, L Y, Blomberg, M A, Chou, T Y, Jiang, M S, Roquemore, E P, Snow, D M, Kreppel, L K, Cole, R N

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A mannose-specific recognition mediates the defasciculation of axons in the leech CNS by Zipser, B, Cole, RN

“…We are studying a mannose-specific recognition mediating the projection of axons in the synaptic neuropil of the embryonic leech CNS. A functional class of…”
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Plant nuclear pore complex proteins are modified by novel oligosaccharides with terminal N-acetylglucosamine by Heese-Peck, A. (Michigan State University, East Lansing, MI.), Cole, R.N, Borkhsenious, O.N, Hart, G.W, Raikhel, N.V

“…Only a few nuclear pore complex (NPC) proteins, mainly in vertebrates and yeast but none in plants, have been well characterized. As an initial step to…”
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The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine by Arnold, C S, Johnson, G V, Cole, R N, Dong, D L, Lee, M, Hart, G W

“…Tau is a family of phosphoproteins that are important in modulating microtubule stability in neurons. In Alzheimer's disease tau is abnormally…”
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Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex by Akimoto, Yoshihiro, Comer, Frank I, Cole, Robert N, Kudo, Akihiko, Kawakami, Hayato, Hirano, Hiroshi, Hart, Gerald W

“…O-linked N-acetylglucosamine (O-GlcNAc) is a ubiquitous nucleocytoplasmic protein modification that has a complex interplay with phosphorylation on…”
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A11 Induced pluripotent stem cells for basic and translational research on HD by Mattis, VB, Svendsen, SP, Ebert, A, Svendsen, CN, King, AR, Casale, M, Winokur, ST, Batugedara, G, Vawter, M, Donovan, PJ, Lock, LF, Thompson, LM, Zhu, Y, Fossale, E, Atwal, RS, Gillis, T, Mysore, J, Li, J-h, Seong, IS, Shen, Y, Chen, X, Wheeler, VC, MacDonald, Marcy E, Gusella, JF, Akimov, S, Arbez, N, Juopperi, T, Ratovitski, T, Chiang, JH, Kim, WR, Chighladze, E, Watkin, E, Zhong, C, Makri, G, Cole, RN, Margolis, RL, Song, H, Ming, G, Ross, CA, Kaye, JA, Daub, A, Sharma, P, Mason, AR, Finkbeiner, S, Yu, J, Thomson, JA, Rushton, D, Brazier, SP, Battersby, AA, Redfern, A, Tseng, H-E, Harrison, AW, Kemp, PJ, Allen, ND, Onorati, M, Castiglioni, V, Cattaneo, E, Arjomand, J

“…BackgroundThe expression of mutant HTT leads to many cellular alterations, including abnormal vesicle recycling, loss of signalling by brain-derived…”
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The specificity of 130-kDa leech sensory afferent proteins is encoded by their carbohydrate epitopes by Bajt, M L, Cole, R N, Zipser, B

“…From early development through adulthood in the leech, sensory afferents, glial cells, and connective tissue express different epitopes located on a group of…”
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