Search Results - "Cole, Neil M."

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    Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity by Cox, Gregory A, Cole, Neil M, Matsumura, Kiichiro, Phelps, Stephanie F, Hauschka, Stephen D, Campbell, Kevin P, Faulkner, John A, Chamberlain, Jeffrey S

    Published in Nature (London) (19-08-1993)
    “…Duchenne and Becker muscular dystrophy (DMD and BMD) are X-linked recessive diseases caused by defective expression of dystrophin. The mdx mouse, an animal…”
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    Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice by Phelps, S F, Hauser, M A, Cole, N M, Rafael, J A, Hinkle, R T, Faulkner, J A, Chamberlain, J S

    Published in Human molecular genetics (01-08-1995)
    “…Duchenne and Becker muscular dystrophy are caused by defects in the dystrophin gene, and are candidates for treatment by gene therapy. We have shown previously…”
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    Transgenic mdx Mice Expressing Dystrophin with a Deletion in the Actin-Binding Domain Display a "Mild Becker" Phenotype by Corrado, Kathleen, Rafael, Jill A., Mills, Patti L., Cole, Neil M., Faulkner, John A., Wang, Kuan, Chamberlain, Jeffrey S.

    Published in The Journal of cell biology (01-08-1996)
    “…The functional significance of the actin-binding domain of dystrophin, the protein lacking in patients with Duchenne muscular dystrophy, has remained elusive…”
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    Contractile properties of diaphragm muscle segments from old mdx and old transgenic mdx mice by Lynch, G S, Rafael, J A, Hinkle, R T, Cole, N M, Chamberlain, J S, Faulkner, J A

    Published in The American journal of physiology (01-06-1997)
    “…Diaphragm muscles of young (4- to 6-mo-old) mdx mice show severe fiber necrosis and have normalized forces and powers 60 and 46% of the values for control…”
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    Muscle sounds are emitted at the resonant frequencies of skeletal muscle by Barry, D.T., Cole, N.M.

    “…The changes in mechanical resonant frequency of whole muscles during twitch and tetanic contractions are compared to changes in frequency components of the…”
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    Prevention of dystrophic pathology in mdx mice by a truncated dystrophin isoform by Rafael, J A, Sunada, Y, Cole, N M, Campbell, K P, Faulkner, J A, Chamberlain, J S

    Published in Human molecular genetics (01-10-1994)
    “…The C-terminal domain of dystrophin is alternatively spliced to produce a variety of tissue and developmental stage-specific isoforms. Recent studies suggest…”
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