Search Results - "Cole, Kathryn E."

Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes by Lombardi, Patrick M, Cole, Kathryn E, Dowling, Daniel P, Christianson, David W

“…[Display omitted] ► Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl- l-lysine. ► HDACs and related deacetylases adopt the α/β arginase fold. ►…”
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Structure of ‘linkerless’ hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket by Tabackman, Alexa A., Frankson, Rochelle, Marsan, Eric S., Perry, Kay, Cole, Kathryn E.

“…Histone deacetylases (HDACs) catalyze the hydrolysis of acetylated lysine side chains in histone and non-histone proteins, and play a critical role in the…”
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Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases by Cole, Kathryn E, Dowling, Daniel P, Boone, Matthew A, Phillips, Andrew J, Christianson, David W

“…Largazole is a macrocyclic depsipeptide originally isolated from the marine cyanobacterium Symploca sp., which is indigenous to the warm, blue-green waters of…”
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Enrichment of innate immune cells from PBMC followed by triple cytokine activation for adoptive immunotherapy by Al-Kadhimi, Zaid, Callahan, Michael, Fehniger, Todd, Cole, Kathryn E., Vose, Julie, Hinrichs, Steven

“…•Microbead depletion of αβ T-cell receptor and CD19+ B-cells from peripheral blood mononuclear cells enriches for NK and γδ T-cells.•Overnight exposure to…”
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Titanium biomaterials: titania needles in the test of the foraminiferan Bathysiphon argenteus by Cole, Kathryn E, Valentine, Ann M

“…Scanning electron microscopy with energy dispersive microanalysis confirms the rare occurrence of a titanium mineral in the test of an organism…”
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HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle by Deardorff, Matthew A., Bando, Masashige, Nakato, Ryuichiro, Watrin, Erwan, Itoh, Takehiko, Minamino, Masashi, Saitoh, Katsuya, Komata, Makiko, Katou, Yuki, Clark, Dinah, Cole, Kathryn E., De Baere, Elfride, Decroos, Christophe, Di Donato, Nataliya, Ernst, Sarah, Francey, Lauren J., Gyftodimou, Yolanda, Hirashima, Kyotaro, Hullings, Melanie, Ishikawa, Yuuichi, Jaulin, Christian, Kaur, Maninder, Kiyono, Tohru, Lombardi, Patrick M., Magnaghi-Jaulin, Laura, Mortier, Geert R., Nozaki, Naohito, Petersen, Michael B., Seimiya, Hiroyuki, Siu, Victoria M., Suzuki, Yutaka, Takagaki, Kentaro, Wilde, Jonathan J., Willems, Patrick J., Prigent, Claude, Gillessen-Kaesbach, Gabriele, Christianson, David W., Kaiser, Frank J., Jackson, Laird G., Hirota, Toru, Krantz, Ian D., Shirahige, Katsuhiko

“…The deacetylase enzyme HDAC8 is identified as a crucial regulator of cohesin in humans, and loss-of-function mutations in the HDAC8 gene are found in patients…”
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Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis by Strunk, Robert J., Piemonte, Katrina M., Petersen, Natasha M., Koutsioulis, Dimitris, Bouriotis, Vassilis, Perry, Kay, Cole, Kathryn E.

“…Polysaccharide deacetylases are bacterial enzymes that catalyze the deacetylation of acetylated sugars on the membranes of Gram‐positive bacteria, allowing…”
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Human splenic myeloid derived suppressor cells: Phenotypic and clustering analysis by Cole, Kathryn E., Ly, Quan P., Hollingsworth, Michael A., Cox, Jesse L., Padussis, James C., Foster, Jason M., Vargas, Luciano M., Talmadge, James E.

“…•Cancer patient spleen a source of immature myeloid cells.•Higher frequency of MDSCs in cancer patient’s peripheral blood versus their spleen.•Clustering…”
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Synthesis, modeling, and biological evaluation of anti-tubulin indole-substituted furanones by Hurysz, Brianna, Evans, Blake A., Laryea, Reuben N., Boyer, Brooke E., Coburn, Taylor E., Dexter, Molly S., Edwards, Marissa A., Faulkner, Grace V., Huss, Rebecca L., Lafferty, Megan M., Manning, Maegan, McNulty, Matthew, Melvin, Sophia J., Mitrow, Christina M., Patel, Roslyn R., Pierce, Kelsey, Russo, Jack, Seminer, Allie M., Sockett, Kaitlynn A., Webster, Nathan R., Cole, Kathryn E., Mowery, Patricia, Pelkey, Erin T.

“…[Display omitted] Due to the central role of tubulin in various cellular functions, it is a validated target for anti-cancer therapeutics. However, many of the…”
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Expansion of distinct peripheral blood myeloid cell subpopulations in patients with rheumatoid arthritis-associated interstitial lung disease by Poole, Jill A, Cole, Kathryn E, Thiele, Geoffrey M, Talmadge, James E, England, Bryant R, Nelson, Amy J, Gleason, Angela, Schwab, Aaron, Gaurav, Rohit, Duryee, Michael J, Bailey, Kristina L, Romberger, Debra J, Hershberger, Daniel, De Graaff, Joel Van, May, Sara M, Walenz, Rhonda, Kramer, Bridget, Mikuls, Ted R

“…Interstitial lung disease (ILD) is associated with significant mortality in rheumatoid arthritis (RA) patients with key cellular players remaining largely…”
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Splenic and PB immune recovery in neoadjuvant treated gastrointestinal cancer patients by Cole, Kathryn E., Ly, Quan P., Hollingsworth, Michael A., Cox, Jesse L., Fisher, Kurt W., Padussis, James C., Foster, Jason M., Vargas, Luciano M., Talmadge, James E.

“…•Immune profile of NCT treated is similar to untreated GI cancer patients.•Decrease in checkpoint marker expression on MDSCs in NCT patients.•Increased PD-1…”
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Implementing a Grant Proposal Writing Exercise in Undergraduate Science Courses To Incorporate Real-World Applications and Critical Analysis of Current Literature by Cole, Kathryn E, Inada, Maki, Smith, Andrew M, Haaf, Michael P

“…Writing is an essential part of a successful career in science. As such, many undergraduate science courses have begun to implement writing assignments that…”
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Synthesis and Biological Evaluation of a Depsipeptidic Histone Deacetylase Inhibitor via a Generalizable Approach Using an Optimized Latent Thioester Solid-Phase Linker by Zang, Xiaoyu, Peraro, Leila, Davison, Ryan T, Blum, Travis R, Vallabhaneni, Deepak, Fennell, Caitlyn E, Cramer, Stephanie L, Shah, Heli K, Wholly, Deirdre M, Fink, Elissa A, Sivak, Jacob T, Ingalls, Kathryn M, Herr, Chelsea T, Lawson, Vernon E, Burnett, Matthew R, Slade, David J, Cole, Kathryn E, Carle, Sigrid A, Miller, Justin S

“…We describe the synthesis of Xyzidepsin, a depsipeptidic analogue of HDAC inhibitor Romidepsin (FK228), using a solid-phase strategy. Our latent thioester…”
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Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization–Fragmentation Reaction Sequence by Harris, Golda G, Lombardi, Patrick M, Pemberton, Travis A, Matsui, Tsutomu, Weiss, Thomas M, Cole, Kathryn E, Köksal, Mustafa, Murphy, Frank V, Vedula, L. Sangeetha, Chou, Wayne K. W, Cane, David E, Christianson, David W

“…Geosmin synthase from Streptomyces coelicolor (ScGS) catalyzes an unusual, metal-dependent terpenoid cyclization and fragmentation reaction sequence. Two…”
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Comparative phenotypes of peripheral blood and spleen cells from cancer patients by Cole, Kathryn E., Ly, Quan P., Hollingsworth, Michael A., Cox, Jesse L., Stromnes, Ingunn M., Padussis, James C., Foster, Jason M., Vargas, Luciano M., Talmadge, James E.

“…•Phenotypic comparison of cells from the spleens and PB of cancer patients.•Increased frequency of CD8+PD-1+ T-cells in cancer patients’ spleens vs…”
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Spermidine and Spermine Catalyze the Formation of Nanostructured Titanium Oxide by Cole, Kathryn E, Valentine, Ann M

“…Naturally occurring polyamines putrescine, cadaverine, spermidine, and spermine are analogues of the species-specific long-chain polyamines found in diatoms…”
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Peptide- and Long-Chain Polyamine- Induced Synthesis of Micro- and Nanostructured Titanium Phosphate and Protein Encapsulation by Cole, Kathryn E, Ortiz, Andrea N, Schoonen, Martin A, Valentine, Ann M

“…Poly(allylamine) (a mimic of biopolyamines) and the R5 peptide (a repeat unit of a silaffin protein isolated from a diatom) induce the formation of mineralized…”
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Structure of the Metal-Dependent Deacetylase LpxC from Yersinia enterocolitica Complexed with the Potent Inhibitor CHIR-090 by Cole, Kathryn E, Gattis, Samuel G, Angell, Heather D, Fierke, Carol A, Christianson, David W

“…The first committed step of lipid A biosynthesis is catalyzed by UDP-(3-O-((R)-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase, a metal-dependent…”
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FT-IR Spectroscopy and Density Functional Theory Calculations of 13C Isotopologues of the Helical Peptide Z‑Aib6‑OtBu by Zeko, Timothy, Hannigan, Steven F, Jacisin, Timothy, Guberman-Pfeffer, Matthew J, Falcone, Eric R, Guildford, Melissa J, Szabo, Christopher, Cole, Kathryn E, Placido, Jessica, Daly, Erin, Kubasik, Matthew A

“…Isotope-edited FT-IR spectroscopy is a combined synthetic and spectroscopic method used to characterize local (e.g., residue-level) vibrational environments of…”
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Impact – Improving patient access time: Arterial cannulation by Cole, Kathryn E, Johnson, Lorna M

“…The overall aim of the project was for an advanced critical care practitioner (ACCP)to develop the clinical competency of arterial catheterisation. The study…”
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