Search Results - "Cole, John J"

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions by Cole, John J, Robertson, Neil A, Rather, Mohammed Iqbal, Thomson, John P, McBryan, Tony, Sproul, Duncan, Wang, Tina, Brock, Claire, Clark, William, Ideker, Trey, Meehan, Richard R, Miller, Richard A, Brown-Borg, Holly M, Adams, Peter D

“…Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust…”
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Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis by Asghar, Sabha, Litherland, Gary J, Cole, John J, McInnes, Iain B, Meek, R M D, Lockhart, John C, Goodyear, Carl S, Crilly, Anne

“…Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis…”
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HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia by Rai, Taranjit Singh, Cole, John J, Nelson, David M, Dikovskaya, Dina, Faller, William J, Vizioli, Maria Grazia, Hewitt, Rachael N, Anannya, Orchi, McBryan, Tony, Manoharan, Indrani, van Tuyn, John, Morrice, Nicholas, Pchelintsev, Nikolay A, Ivanov, Andre, Brock, Claire, Drotar, Mark E, Nixon, Colin, Clark, William, Sansom, Owen J, Anderson, Kurt I, King, Ayala, Blyth, Karen, Adams, Peter D

“…Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of…”
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Searchlight: automated bulk RNA-seq exploration and visualisation using dynamically generated R scripts by Cole, John J, Faydaci, Bekir A, McGuinness, David, Shaw, Robin, Maciewicz, Rose A, Robertson, Neil A, Goodyear, Carl S

“…Once bulk RNA-seq data has been processed, i.e. aligned and then expression and differential tables generated, there remains the essential process where the…”
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Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity by Rai, Taranjit Singh, Glass, Mandy, Cole, John J, Rather, Mohammad I, Marsden, Morgan, Neilson, Matthew, Brock, Claire, Humphreys, Ian R, Everett, Roger D, Adams, Peter D

“…The HIRA histone chaperone complex deposits histone H3.3 into nucleosomes in a DNA replication- and sequence-independent manner. As herpesvirus genomes enter…”
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Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability by Nelson, David M, Jaber-Hijazi, Farah, Cole, John J, Robertson, Neil A, Pawlikowski, Jeffrey S, Norris, Kevin T, Criscione, Steven W, Pchelintsev, Nikolay A, Piscitello, Desiree, Stong, Nicholas, Rai, Taranjit Singh, McBryan, Tony, Otte, Gabriel L, Nixon, Colin, Clark, William, Riethman, Harold, Wu, Hong, Schotta, Gunnar, Garcia, Benjamin A, Neretti, Nicola, Baird, Duncan M, Berger, Shelley L, Adams, Peter D

“…Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear,…”
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DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML by Lund, Kirstin, Cole, John J, VanderKraats, Nathan D, McBryan, Tony, Pchelintsev, Nikolay A, Clark, William, Copland, Mhairi, Edwards, John R, Adams, Peter D

“…Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors,…”
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Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest by Dikovskaya, Dina, Cole, John J., Mason, Susan M., Nixon, Colin, Karim, Saadia A., McGarry, Lynn, Clark, William, Hewitt, Rachael N., Sammons, Morgan A., Zhu, Jiajun, Athineos, Dimitris, Leach, Joshua D.G., Marchesi, Francesco, van Tuyn, John, Tait, Stephen W., Brock, Claire, Morton, Jennifer P., Wu, Hong, Berger, Shelley L., Blyth, Karen, Adams, Peter D.

“…Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently…”
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No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing by Cole, John J., McColl, Alison, Shaw, Robin, Lynall, Mary-Ellen, Cowen, Philip J., de Boer, Peter, Drevets, Wayne C., Harrison, Neil, Pariante, Carmine, Pointon, Linda, Goodyear, Carl, Bullmore, Edward, Cavanagh, Jonathan

“…The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation…”
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Large‐scale plasma proteomics can reveal distinct endotypes in chronic obstructive pulmonary disease and severe asthma by Suzuki, Masaru, Cole, John J., Konno, Satoshi, Makita, Hironi, Kimura, Hiroki, Nishimura, Masaharu, Maciewicz, Rose A.

“…Background Chronic airway diseases including chronic obstructive pulmonary disease (COPD) and asthma are heterogenous in nature and endotypes within are…”
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Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis by Thümmler, Katja, Williams, Mark TS, Kitson, Susan, Sood, Shatakshi, Akbar, Moeed, Cole, John J, Hunter, Ewan, Soutar, Richard, Goodyear, Carl S

“…Bone disease represents a major cause of morbidity and mortality in Multiple Myeloma (MM); primarily driven by osteoclasts whose differentiation is dependent…”
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Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential by Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John J, Arseni, Diana, Mücklisch, Steve, Edgar, Julia M, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher

“…Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by…”
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Dissecting the molecular control of immune cell accumulation in the inflamed joint by Prendergast, Catriona T, Benson, Robert A, Scales, Hannah E, Bonilha, Caio Santos, Cole, John J, McInnes, Iain, Brewer, James M, Garside, Paul

“…Mechanisms governing entry and exit of immune cells into and out of inflamed joints remain poorly understood. We sought herein to identify the key molecular…”
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The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80 by Smith, Emma L, Somma, Domenico, Kerrigan, David, McIntyre, Zoe, Cole, John J, Liang, Kai Ling, Kiely, Patrick A, Keeshan, Karen, Carmody, Ruaidhrí J

“…Abstract Phosphorylation of the NF-κB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80…”
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Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection by Kästele, Verena, Mayer, Johannes, Lee, Edward S., Papazian, Natalie, Cole, John J., Cerovic, Vuk, Belz, Gabrielle, Tomura, Michio, Eberl, Gerard, Goodyear, Carl, Maciewicz, Rose A., Wall, Daniel, Cupedo, Tom, Withers, David R., Milling, Simon

“…Innate lymphoid cells (ILCs) are enriched in mucosae and have been described as tissue-resident. Interestingly, ILCs are also present within lymph nodes (LNs),…”
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Fibroblast growth factor 9 (FGF9)‐mediated neurodegeneration: Implications for progressive multiple sclerosis? by Thümmler, Katja, Wrzos, Claudia, Franz, Jonas, McElroy, Daniel, Cole, John J., Hayden, Lorna, Arseni, Diana, Schwarz, Friedrich, Junker, Andreas, Edgar, Julia M., Kügler, Sebastian, Neef, Andreas, Wolf, Fred, Stadelmann, Christine, Linington, Christopher

“…Aims Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and other neurological and psychiatric conditions, but there is…”
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Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function by van Tuyn, John, Jaber-Hijazi, Farah, MacKenzie, Douglas, Cole, John J., Mann, Elizabeth, Pawlikowski, Jeff S., Rai, Taranjit Singh, Nelson, David M., McBryan, Tony, Ivanov, Andre, Blyth, Karen, Wu, Hong, Milling, Simon, Adams, Peter D.

“…On acquisition of an oncogenic mutation, primary human and mouse cells can enter oncogene-induced senescence (OIS). OIS is characterized by a stable…”
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GAS2 Upregulation Is a Targetable Vulnerability in Chronic Myeloid Leukemia by Ramirez-Guzman, Lizbeth A, Huang, Wenjing, Cole, John J, Jørgensen, Heather G

“…Tyrosine kinase inhibitors (TKIs), such as imatinib (IM), increase the survival of chronic myeloid leukemia (CML) patients but do not eradicate the disease as…”
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Evolutionary History of the ADRB2 Gene in Humans by Wilson, Richard H., Moran, Colin N., Cole, John J., Pitsiladis, Yannis P., Bailey, Mark E.S.

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Dual Inhibition of MDM2 and BET Cooperate to Eradicate Acute Myeloid Leukemia by Latif, Anne-Louise, Cole, John J, Monteiro Campos, Joana, Clark, William, McGarry, Lynn, Brock, Claire, Newcombe, Ashley, Keeshan, Karen, Copland, Mhairi, Adams, Peter D

“…Background: There remains a critical requirement for novel therapies for Acute Myeloid Leukemia (AML). Bromodomain and extra-terminal domain (BET) inhibitors…”
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