Search Results - "Cole, Grace"

MicroRNAs in Pancreatic Cancer: biomarkers, prognostic, and therapeutic modulators by Daoud, Afra Z, Mulholland, Eoghan J, Cole, Grace, McCarthy, Helen O

“…A severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical concern. The…”
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Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery by McCarthy, Helen O, McCaffrey, Joanne, McCrudden, Cian M, Zholobenko, Aleksey, Ali, Ahlam A, McBride, John W, Massey, Ashley S, Pentlavalli, Sreekanth, Chen, Kun-Hung, Cole, Grace, Loughran, Stephen P, Dunne, Nicholas J, Donnelly, Ryan F, Kett, Victoria L, Robson, Tracy

“…The design of a non-viral gene delivery vehicle capable of delivering and releasing a functional nucleic acid cargo intracellularly remains a formidable…”
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Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression by Coulombe, Patrick, Cole, Grace, Fentiman, Amanda, Parker, Jeremy D. K., Yung, Eric, Bilenky, Misha, Degefie, Lemlem, Lac, Patrick, Ling, Maggie Y. M., Tam, Derek, Humphries, R. Keith, Karsan, Aly

“…Hematopoietic stem and progenitor cells (HSPCs) originate from an endothelial-to-hematopoietic transition (EHT) during embryogenesis. Characterization of early…”
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Rehabilitation of coral reefs through removal of macroalgae: state of knowledge and considerations for management and implementation by Ceccarelli, Daniela M., Loffler, Zoe, Bourne, David G., Al Moajil‐Cole, Grace S., Boström‐Einarsson, Lisa, Evans‐Illidge, Elizabeth, Fabricius, Katharina, Glasl, Bettina, Marshall, Paul, McLeod, Ian, Read, Mark, Schaffelke, Britta, Smith, Adam K., Jorda, Georgina T., Williamson, David H., Bay, Line

“…Coral reef ecosystems are under increasing pressure by multiple stressors that degrade reef condition and function. Although improved management systems have…”
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Digital plasmonic holography with iterative phase retrieval for sensing by Spies, Ryan M, Cole, Grace H, Engevik, Marit A, Nordberg, Britta G, Scharnick, Evan A, Vliem, Isaac M, Brolo, Alexandre G, Lindquist, Nathan C

“…Propagating surface plasmon waves have been used for many applications including imaging and sensing. However, direct in-plane imaging of micro-objects with…”
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Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation by Cole, Grace, McCaffrey, Joanne, Ali, Ahlam A., McBride, John W., McCrudden, Cian M., Vincente-Perez, Eva M., Donnelly, Ryan F., McCarthy, Helen O.

“…DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited…”
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Incident Diversionary Routing: Survey of Influences and Decisions by Cole, Grace, Wolshon, Brian, Schmidt, Jeffrey

“…When confronted with congestion and delay, drivers often divert their route. Depending on factors like purpose, urgency, destination, route alternatives, type…”
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Motivators and Preferences of Route Diversion During Roadway Incidents by Cole, Grace

“…When confronted with congestion and delay, drivers often divert their route. Depending on factors like purpose, urgency, destination, route alternatives, type…”
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Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery by McErlean, Emma M., Ziminska, Monika, McCrudden, Cian M., McBride, John W., Loughran, Stephen P., Cole, Grace, Mulholland, Eoghan J., Kett, Vicky, Buckley, Niamh E., Robson, Tracy, Dunne, Nicholas J., McCarthy, Helen O.

“…The design of a non-viral gene delivery system that can release a functional nucleic acid at the intracellular destination site is an exciting but also…”
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DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen by Cole, Grace, Ali, Ahlam A., McErlean, Emma, Mulholland, Eoghan J., Short, Amy, McCrudden, Cian M., McCaffrey, Joanne, Robson, Tracy, Kett, Vicky L., Coulter, Jonathan A., Dunne, Nicholas J., Donnelly, Ryan F., McCarthy, Helen O.

“…[Display omitted] Castrate resistant prostate cancer (CRPC) remains a major challenge for healthcare professionals. Immunotherapeutic approaches, including DNA…”
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Meis1 Establishes the Pre-Hemogenic Endothelial State Prior to Runx1 Expression by Cole, Grace, Coulombe, Patrick, Fentiman, Amanda, Parker, Jeremy, Yung, Eric, Degefie, Lemlem, Lac, Patrick, Ling, Maggie, Tam, Derek, Humphries, R. Keith, Karsan, Aly

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DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system by Cole, Grace, Ali, Ahlam A., McCrudden, Cian M., McBride, John W., McCaffrey, Joanne, Robson, Tracy, Kett, Vicky L., Dunne, Nicholas J., Donnelly, Ryan F., McCarthy, Helen O.

“…[Display omitted] Dissolvable microneedles can be employed to deliver DNA to antigen presenting cells within the skin. However, this technology faces two main…”
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Rational design and characterisation of an amphipathic cell penetrating peptide for non-viral gene delivery by McErlean, Emma M., McCrudden, Cian M., McBride, John W., Cole, Grace, Kett, Vicky L., Robson, Tracy, Dunne, Nicholas J, McCarthy, Helen O.

“…[Display omitted] RALA is a cationic amphipathic peptide which has shown great promise as an efficient, multifunctional delivery system for the delivery of…”
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DNA Vaccination for Cervical Cancer; A Novel Technology Platform of RALA Mediated Gene Delivery via Polymeric Microneedles by Ali, AA, McCrudden, CM, McCaffrey, J, McBride, JW, Cole, G, Dunne, NJ, Robson, T, Kissenpfennig, A, Donnelly, RF, McCarthy, HO

“…Abstract HPV subtypes (16, 18) are associated with the development of cervical cancer, with oncoproteins E6 and E7 responsible for pathogenesis. The goal of…”
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Shift of the insoluble content of the proteome in the aging mouse brain by Molzahn, Cristen, Kuechler, Erich R, Zemlyankina, Irina, Nierves, Lorenz, Ali, Tahir, Cole, Grace, Wang, Jing, Albu, Razvan F, Zhu, Mang, Cashman, Neil R, Gilch, Sabine, Karsan, Aly, Lange, Philipp F, Gsponer, Jörg, Mayor, Thibault

“…During aging, the cellular response to unfolded proteins is believed to decline, resulting in diminished proteostasis. In model organisms, such as proteostatic…”
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Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease: A Randomized Clinical Trial by Stevens, Kara N, Creanor, Siobhan, Jeffery, Alison, Whone, Alan, Zajicek, John, Foggo, Andy, Jones, Ben, Chapman, Rebecca, Cocking, Laura, Wilks, Jonny, Webb, Doug, Carroll, Camille

“…Current treatments manage symptoms of Parkinson disease (PD), but no known treatment slows disease progression. Preclinical and epidemiological studies support…”
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Efficacy and Safety Results of Prolong-9FP Clinical Program of Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (rIX-FP) in Previously Treated Patients with Hemophilia B by Santagostino, Elena, Voigt, Christine, Wolko, Denise, Cole, Grace, Li, Yanyan, Jacobs, Iris C.

“…▪ A fusion protein genetically linking recombinant human coagulation FIX with recombinant human albumin (rIX-FP) has been developed with an improved PK…”
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Spk-8011: Preliminary Results from a Phase 1/2 Dose Escalation Trial of an Investigational AAV-Mediated Gene Therapy for Hemophilia a by George, Lindsey A., Ragni, Margaret V., Samelson-Jones, Ben J., Cuker, Adam, Runoski, Alexa R., Cole, Grace, Wright, Fraser, Chen, Yifeng, Hui, Daniel J, Wachtel, Katie, Takefman, Daniel, Couto, Linda B., Reape, Kathleen Z., Carr, Marcus E., Anguela, Xavier M., High, Katherine A.

“…▪ Background: Hemophilia A therapy is currently based on intravenous administration of exogenous FVIII protein either on demand to treat bleeding or…”
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DNA vaccination for prostate cancer: key concepts and considerations by Cole, Grace, McCaffrey, Joanne, Ali, Ahlam A., McCarthy, Helen O.

“…While locally confined prostate cancer is associated with a low five year mortality rate, advanced or metastatic disease remains a major challenge for…”
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Shakespeare’s Binary: Crossdressing and Alternative Gender Performances in the Sonnets, Twelfth Night, and the Merchant of Venice by Cole, Hannah Grace-Kelly

“…This thesis explores shifts in power through subverting prescribed gender binaries within a selection of Shakespeare’s sonnets and Shakespeare’s plays Twelfth…”
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