Search Results - "Cole, Edward S."

The Role of Mannosylated Enzyme and the Mannose Receptor in Enzyme Replacement Therapy by Du, Hong, Levine, Mark, Ganesa, Chandrashekar, Witte, David P., Cole, Edward S., Grabowski, Gregory A.

“…Lysosomal acid lipase (LAL) is the critical enzyme for the hydrolysis of triglycerides (TGs) and cholesteryl esters (CEs) in lysosomes. LAL defects cause…”
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Effect of genetic background on glycosylation heterogeneity in human antithrombin produced in the mammary gland of transgenic goats by Zhou, Qun, Kyazike, Josephine, Echelard, Yann, Meade, Harry M., Higgins, Elizabeth, Cole, Edward S., Edmunds, Tim

“…Glycosylation is involved in the correct folding, targeting, bioactivity and clearance of therapeutic glycoproteins. With the development of transgenic animals…”
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Recombinant Human Thyroid Stimulating Hormone: Development of a Biotechnology Product for Detection of Metastatic Lesions of Thyroid Carcinoma by Cole, Edward S, Lee, Karen, Lauziere, Kevin, Kelton, Christine, Chappel, Scott, Weintraub, Bruce, Ferrara, Dawn, Peterson, Pamela, Bernasconi, Rick, Edmunds, Tim, Richards, Susan, Dickrell, Lydia, Kleeman, James M, McPherson, John M, Pratt, Bruce M

“…We have genetically engineered a cell line, and developed a reproducible process, for the expression and purification of biologically active recombinant human…”
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Transgenically Produced Human Antithrombin: Structural and Functional Comparison to Human Plasma–Derived Antithrombin by Edmunds, Tim, Van Patten, Scott M., Pollock, Julie, Hanson, Eric, Bernasconi, Richard, Higgins, Elizabeth, Manavalan, Partha, Ziomek, Carol, Meade, Harry, McPherson, John M., Cole, Edward S.

“…Recombinant human antithrombin (rhAT) produced in transgenic goat milk was purified to greater than 99%. The specific activity of the rhAT was identical to…”
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The effect of posttranslational modifications on the in vitro activity of recombinant human thyroid-stimulating hormone by Sendak, Rebecca A, Ganesa, Chandrashekar, Lee, Karen L, Harrahy, John J, Théberge, Roger, Morgan, Charles J, Cole, Edward S, Kohn, Leonard D, Mattaliano, Robert J

“…Posttranslational modification can influence the biologic activity of recombinant proteins. The effects of beta-subunit C-terminal truncation, oligosaccharide…”
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Biological activity and metabolic clearance of a recombinant human thyrotropin produced in Chinese hamster ovary cells by Thotakura, N R, Desai, R K, Bates, L G, Cole, E S, Pratt, B M, Weintraub, B D

“…The presence and specific structures of the oligosaccharides on TSH have been shown to be important for its production and bioactivity. Since the carbohydrate…”
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Comparison of Two In Vitro Methods for the Measurement of Recombinant Human TSH Bioactivity by Sendak, Rebecca A., Wang, Fei, Geagan, Laura B., Armstrong, Lori A., Thyne, Charles D., Cole, Edward S., Mattaliano, Robert J.

“…Thyroid stimulating hormone (TSH), a pituitary glycoprotein hormone, is a potent inducer of intracellular cAMP production. Two methods for measuring TSH…”
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Oxidation of Methionine Residues in Antithrombin by Van Patten, Scott M., Hanson, Eric, Bernasconi, Richard, Zhang, Kate, Manavalan, Partha, Cole, Edward S., McPherson, John M., Edmunds, Tim

“…Commercially available human plasma-derived preparations of the serine protease inhibitor antithrombin (AT) were shown to contain low levels of oxidation, and…”
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Oxidation of methionine residues in antithrombin. Effects on biological activity and heparin binding by Van Patten, S M, Hanson, E, Bernasconi, R, Zhang, K, Manavalan, P, Cole, E S, McPherson, J M, Edmunds, T

“…Commercially available human plasma-derived preparations of the serine protease inhibitor antithrombin (AT) were shown to contain low levels of oxidation, and…”
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Studies on the microheterogeneity and in vitro activity of glycosylated and nonglycosylated recombinant human prolactin separated using a novel purification process by Price, A E, Logvinenko, K B, Higgins, E A, Cole, E S, Richards, S M

“…Recombinant human PRL was produced in a murine C127 cell expression system and purified to greater than 97% homogeneity using anion and cation exchange…”
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Transgenically Produced Human Antithrombin: Structural and Functional Comparison to Human Plasma–Derived Antithrombin by Edmunds, Tim, Van Patten, Scott M., Pollock, Julie, Hanson, Eric, Bernasconi, Richard, Higgins, Elizabeth, Manavalan, Partha, Ziomek, Carol, Meade, Harry, McPherson, John M., Cole, Edward S.

“…Recombinant human antithrombin (rhAT) produced in transgenic goat milk was purified to greater than 99%. The specific activity of the rhAT was identical to…”
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Transferrin binding and iron uptake in mouse hepatocytes by Cole, E S, Glass, J

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Characterization of the microheterogeneity of recombinant primate prolactin: implications for posttranslational modifications of the hormone in vivo by Cole, E S, Nichols, E H, Lauziere, K, Edmunds, T, McPherson, J M

“…Recombinant baboon and monkey prolactins were expressed in murine C127 cells. The hormones were purified from the conditioned media of these cells using a…”
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Cytosol Intermediates in the Transport of Iron by Nunez, Marco Tulio, Cole, Edward S., Glass, Jonathan

“…Three 59Fe-labeled nonheme components of the cytosol were identified when rabbit reticulocytes were incubated with 59Fe-labeled plasma under conditions in…”
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REPORT OF THE COMMITTEE ON WATER CONSUMPTION by Cole, Edward S., Brush, Wm. W., Chester, J. N., Dunlap, John. W.

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REPORT OF COMMITTEE ON WATER CONSUMPTION AMERICAN WATER WORKS ASSOCIATION, 1913-1915 by Chester, John N., Potter, Alexander, Montoulieu, H. J., Cramer, W. S., Davis, E. E., Cole, Edward S.

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DISCUSSION ON REPORT OF THE COMMITTEE ON METHODS AND RECORDS OF WATER WASTE CONTROL [with DISCUSSION] by Brush, William W., Fuller, Bohmann, Henry P., Cole, Edward S., Foreman, Charles S., Gwinn, Dow R., Saville, Caleb Mills, Chester, John N., Chambers, John, Hanna, David McLean

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THE VALUE OF WATER WASTE SURVEYS IN ADDITION TO THE LOCATION OF LEAKS [with DISCUSSION] by Cole, Edward S., Behney, C. C., Heffernan, D. A., Heffernan, D. D., McCaffrey, Wm. A., Mr. Pierce, Mr. Patten, Cole, E. S., Mr. Mc Dowell, Spire, L. S., Bohmann, H. P., Gidley, Henry T., Stewart, Elon P., Mr. Taylor

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ARTESIAN WELLS AND METHODS OF PUMPING THEM [with DISCUSSION] by Kilpatrick, John D., McFarland, Chester R., Kilpatrick, J. D., Moore, John W., Baker, M. N., Wills, Wirt J., Bulkeley, Oscar, Reimer, A. A., Berry, J. P., Cole, Edward S., West, Francis D.

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PROCEEDINGS THIRTY-SIXTH ANNUAL CONVENTION, AMERICAN WATER WORKS ASSOCIATION [with DISCUSSION] by Keeler, H. E., Dill, Howard A., Morgan, Henry B., Caird, J. M., Alvord, John W., Bartow, Dabney H., Bartow, Edward, Little, B. C., Sherrerd, Morris R., Caldwell, James H., O'Brien, Dennis F., Wood, Charles R., Conard, W. R., Diven, J. M., Cole, Edward S., Chester, J. N., Cramer, W. S., Brush, William W., Dunlap, John H., McFarland, Chester R., Highland, Scotland G., McClintock, James R., Klein, William I., McCarthy, William, Leisen, Theodore A., Salmon, C. B., Baker, M. N., Ganz, Albert F., Henderson, Charles R., Jackson, Daniel D., Jackson, Robert H., Minor, Edward E., ARMSTRONG, JAMES W., BURDICK, CHARLES B., GOODRICH, E. P.

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