Search Results - "Coldren, Christopher D."

Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis by Yang, Ivana V, Coldren, Christopher D, Leach, Sonia M, Seibold, Max A, Murphy, Elissa, Lin, Jia, Rosen, Rachel, Neidermyer, Amanda J, McKean, David F, Groshong, Steve D, Cool, Carlyne, Cosgrove, Gregory P, Lynch, David A, Brown, Kevin K, Schwarz, Marvin I, Fingerlin, Tasha E, Schwartz, David A

“…Idiopathic pulmonary fibrosis (IPF) is an untreatable lung disease with a median survival of only 3-5 years that is diagnosed using a combination of clinical,…”
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Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non–small cell lung carcinoma by Frederick, Barbara A, Helfrich, Barbara A, Coldren, Christopher D, Zheng, Di, Chan, Dan, Bunn, Jr, Paul A, Raben, David

“…The modest response of patients with head and neck squamous cell carcinoma (HNSCC) and non–small cell lung carcinoma (NSCLC) to epithelial growth factor…”
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Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells by Marek, Lindsay, Ware, Kathryn E, Fritzsche, Alexa, Hercule, Paula, Helton, Wallace R, Smith, Jennifer E, McDermott, Lee A, Coldren, Christopher D, Nemenoff, Raphael A, Merrick, Daniel T, Helfrich, Barbara A, Bunn, Jr, Paul A, Heasley, Lynn E

“…Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific…”
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Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines by Witta, Samir E, Gemmill, Robert M, Hirsch, Fred R, Coldren, Christopher D, Hedman, Karla, Ravdel, Larisa, Helfrich, Barbara, Dziadziuszko, Rafal, Chan, Daniel C, Sugita, Michio, Chan, Zeng, Baron, Anna, Franklin, Wilbur, Drabkin, Harry A, Girard, Luc, Gazdar, Adi F, Minna, John D, Bunn, Jr, Paul A

“…The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non-small cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as…”
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Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis by Nick, Jerry A., Coldren, Christopher D., Geraci, Mark W., Poch, Katie R., Fouty, Brian W., O'Brien, James, Gruber, Michael, Zarini, Simona, Murphy, Robert C., Kuhn, Katherine, Richter, Don, Kast, Kelly R., Abraham, Edward

“…Recombinant human activated protein C (rhAPC) is a natural anticoagulant with potentially important anti-inflammatory properties. In humans with severe sepsis,…”
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Baseline Gene Expression Predicts Sensitivity to Gefitinib in Non–Small Cell Lung Cancer Cell Lines by Coldren, Christopher D, Helfrich, Barbara A, Witta, Samir E, Sugita, Michio, Lapadat, Razvan, Zeng, Chan, Barón, Anna, Franklin, Wilbur A, Hirsch, Fred R, Geraci, Mark W, Bunn, Jr, Paul A

“…Tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) produce objective responses in a minority of patients with advanced-stage…”
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Gene Microarray Analysis of Peripheral Blood Cells in Pulmonary Arterial Hypertension by Bull, Todd M, Coldren, Christopher D, Moore, Mark, Sotto-Santiago, Sylk M, Pham, David V, Nana-Sinkam, S. Patrick, Voelkel, Norbert F, Geraci, Mark W

“…The importance of genetic predisposition, inflammation, and autoimmune mechanisms in the development of pulmonary arterial hypertension (PAH) is becoming…”
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Randomization in laboratory procedure is key to obtaining reproducible microarray results by Yang, Hyuna, Harrington, Christina A, Vartanian, Kristina, Coldren, Christopher D, Hall, Rob, Churchill, Gary A

“…The quality of gene expression microarray data has improved dramatically since the first arrays were introduced in the late 1990s. However, the reproducibility…”
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Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine by Barthel, Benjamin L, Zhang, Zhiyong, Rudnicki, Daniel L, Coldren, Christopher D, Polinkovsky, Margaret, Sun, Hengrui, Koch, Gary G, Chan, Daniel C. F, Koch, Tad H

“…Doxazolidine (Doxaz) is a functionally distinct formaldehyde conjugate of doxorubicin (Dox) that induces cancer cell death in Dox-sensitive and resistant…”
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Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease by Bahr, Timothy M, Hughes, Grant J, Armstrong, Michael, Reisdorph, Rick, Coldren, Christopher D, Edwards, Michael G, Schnell, Christina, Kedl, Ross, LaFlamme, Daniel J, Reisdorph, Nichole, Kechris, Katerina J, Bowler, Russell P

“…Although most cases of chronic obstructive pulmonary disease (COPD) occur in smokers, only a fraction of smokers develop the disease. We hypothesized distinct…”
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Somatic Chromosome Abnormalities in the Lungs of Patients with Pulmonary Arterial Hypertension by ALDRED, Micheala A, COMHAIR, Suzy A, COLDREN, Christopher D, VARELLA-GARCIA, Marileila, ASOSINGH, Kewal, WEILING XU, NOONS, George P, THISTLETHWAITE, Patricia A, TUDER, Rubin M, ERZURUM, Serpil C, GERACI, Mark W

“…Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to…”
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Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development by PITTS, Todd M, CHOON TAN, Aik, KORCH, Christopher, ECKHARDT, S. Gail, KULIKOWSKI, Gillian N, TENTLER, John J, BROWN, Amy M, FLANIGAN, Sara A, LEONG, Stephen, COLDREN, Christopher D, HIRSCH, Fred R, VARELLA-GARCIA, Marileila

“…A plethora of agents is in early stages of development for colorectal cancer (CRC), including those that target the insulin-like growth factor I receptor…”
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The Rational Design and Construction of a Cuboidal Iron--Sulfur Protein by Coldren, Christopher D., Hellinga, Homme W., Caradonna, John P.

“…Rational protein design is an emerging approach for testing general theories of protein chemistry through the creation of new structures and functions. Here we…”
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Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias by Steele, Mark P, Luna, Leah G, Coldren, Christopher D, Murphy, Elissa, Hennessy, Corinne E, Heinz, David, Evans, Christopher M, Groshong, Steve, Cool, Carlyne, Cosgrove, Gregory P, Brown, Kevin K, Fingerlin, Tasha E, Schwarz, Marvin I, Schwartz, David A, Yang, Ivana V

“…Idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous, somewhat unpredictable diseases characterized by progressive scarring of the…”
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Progressive endobronchial premalignancy: marked by original CIN by Coldren, Christopher D, Miller, York E

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Integrative omics approach identifies interleukin-16 as a biomarker of emphysema by Bowler, Russell P, Bahr, Timothy M, Hughes, Grant, Lutz, Sharon, Kim, Yu-Il, Coldren, Christopher D, Reisdorph, Nichole, Kechris, Katerina J

“…Interleukin-16 (IL-16) is a multifunctional cytokine that has been associated with autoimmune and allergic diseases. To investigate comprehensively whether…”
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Emphysema lung tissue gene expression profiling by Golpon, Heiko A, Coldren, Christopher D, Zamora, Martin R, Cosgrove, Gregory P, Moore, Mark D, Tuder, Rubin M, Geraci, Mark W, Voelkel, Norbert F

“…Emphysema occurs in a subgroup of patients with chronic obstructive pulmonary disease and patients with the genetic defect of alpha(1)-antitrypsin deficiency…”
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Application of SNP Microarrays to the Genome-Wide Analysis of Chromosomal Instability in Premalignant Airway Lesions by NAKACHI, Ichiro, RICE, Jessica L, GAO, Bifeng, MERRICK, Daniel T, MILLER, York E, GERACI, Mark W, COLDREN, Christopher D, EDWARDS, Michael G, STEARMAN, Robert S, GLIDEWELL, Steven C, VARELLA-GARCIA, Marileila, FRANKLIN, Wilbur A, KEITH, Robert L, LEWIS, Marina T

“…Chromosomal instability is central to the process of carcinogenesis. The genome-wide detection of somatic chromosomal alterations (SCA) in small premalignant…”
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Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome by Glidewell, Steven C., Miyamoto, Shelley D., Grossfeld, Paul D., Clouthier, David E., Coldren, Christopher D., Stearman, Robert S., Geraci, Mark W.

“…Background Hypoplastic left heart syndrome (HLHS) is a heterogeneous, lethal combination of congenital malformations characterized by severe underdevelopment…”
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Altered Immune Phenotype in Peripheral Blood Cells of Patients with Scleroderma-Associated Pulmonary Hypertension by Risbano, Michael G, Meadows, Christina A., Coldren, Christopher D., Jenkins, Tiffany J., Edwards, Michael G., Collier, David, Huber, Wendy, Mack, Douglas G., Fontenot, Andrew P., Geraci, Mark W., Bull, Todd M

“…Pulmonary arterial hypertension is a common and fatal complication of scleroderma that may involve inflammatory and autoimmune mechanisms. Alterations in the…”
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