Search Results - "Colca, J R"

Mitochondrial target of thiazolidinediones by Colca, J. R., McDonald, W. G., Kletzien, R. F.

“…Insulin‐sensitizing thiazolidinediones exert a pleiotropic pharmacology with therapeutic potential in a number of disease states ranging from metabolic…”
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Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer by Colca, J R, VanderLugt, J T, Adams, W J, Shashlo, A, McDonald, W G, Liang, J, Zhou, R, Orloff, D G

“…It may be possible to achieve insulin sensitivity through the recently identified mitochondrial target of thiazolidinediones (mTOT), thereby avoiding…”
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New oral thiazolidinedione antidiabetic agents act as insulin sensitizers by HOFMANN, C. A, COLCA, J. R

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Compensatory alterations for insulin signal transduction and glucose transport in insulin-resistant diabetes by Bonini, J A, Colca, J R, Dailey, C, White, M, Hofmann, C

“…Insulin binding activates the receptor tyrosine kinase toward the insulin receptor substrate-1 (IRS-1). Phosphorylated IRS-1 then interacts with the p85 alpha…”
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Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance by Hofmann, C, Lorenz, K, Braithwaite, S S, Colca, J R, Palazuk, B J, Hotamisligil, G S, Spiegelman, B M

“…As obesity is a major risk factor for noninsulin-dependent diabetes mellitus, adipose tissue may generate a mediator that influences the activity of insulin on…”
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Insulin stimulates the phosphorylation of calmodulin in intact adipocytes by Colca, J R, DeWald, D B, Pearson, J D, Palazuk, B J, Laurino, J P, McDonald, J M

“…Phosphorylation of cellular proteins is known to play an important role in mediating the metabolic effects of insulin in target cells. Here we show that…”
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Activation of calcium and calmodulin dependent protein kinase II during stimulation of insulin secretion by Norling, L L, Colca, J R, Kelly, P T, McDaniel, M L, Landt, M

“…Pancreatic islets contain an alloxan sensitive, calcium and calmodulin dependent protein kinase (CaM-PK) which may play an important part in the cellular…”
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Malonyl coenzyme A and adiposity in the dahl salt-sensitive rat: Effects of pioglitazone by Kurowski, T.G., Saha, A.K., Cunningham, B.A., Holbert, R.I., Colca, J.R., Corkey, B.E., Ruderman, N.B.

“…These studies were designed to assess the effects of pioglitazone, a new oral antidiabetic agent that acts by improving insulin sensitivity, on blood pressure,…”
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Glucose transport deficiency in diabetic animals is corrected by treatment with the oral antihyperglycemic agent pioglitazone by Hofmann, C, Lorenz, K, Colca, J R

“…Insulin-stimulated glucose uptake into muscle and fat involves regulation of the subcellular distribution and the expression of a specific facilitative glucose…”
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Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol by Saha, A K, Kurowski, T G, Colca, J R, Ruderman, N B

“…Insulin resistance is present in liver and muscle of subjects with type 2 diabetes and obesity. Recent studies suggest that such insulin resistance could be…”
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Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats by Colca, J. R., Dailey, C. F., Palazuk, B. J., Hillman, R. M., Dinh, D. M., Melchior, G. W., Spilman, C. H.

“…Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats. J R Colca , C F Dailey , B J…”
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Regulation of Ca2+ homeostasis by islet endoplasmic reticulum and its role in insulin secretion by Wolf, B A, Colca, J R, Turk, J, Florholmen, J, McDaniel, M L

“…Changes in intracellular Ca2+ concentrations have a major role in the regulation of insulin secretion by islet beta-cells. It has recently become apparent that…”
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Synthesis and Biological Activity of Metabolites of the Antidiabetic, Antihyperglycemic Agent Pioglitazone by Tanis, Steven P., Parker, Timothy T., Colca, Jerry R., Fisher, Roberta M., Kletzein, Rolf F.

“…Pioglitazone (5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione, 2) is a prototypical antidiabetic thiazolidinedione that had been evaluated for…”
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Activation of an islet cell plasma membrane (Ca2+ + Mg2+)-ATPase by calmodulin and Ca-EGTA by Kotagal, N, Colca, J R, McDaniel, M L

“…Islet cell plasma membranes contain a calcium-stimulated and magnesium-dependent ATPase (Ca2+ + Mg2+)-ATPase) which requires calmodulin for maximum enzyme…”
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Reduced expression of hexokinase II in insulin-resistant diabetes by S S Braithwaite, B Palazuk, J R Colca, C W Edwards, 3rd, C Hofmann

“…Reduced expression of hexokinase II in insulin-resistant diabetes. S S Braithwaite , B Palazuk , J R Colca , C W Edwards, 3rd and C Hofmann Medical Service,…”
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Reduced expression of hexokinase II in insulin-resistant diabetes by BRAITHWAITE, S. S, PALAZUK, B, COLCA, J. R, EDWARDS, C. W, HOFMANN, C

“…The regulation of hexokinase II (HKII) was examined in fat and skeletal muscle of an animal model of non-insulin-dependent diabetes mellitus, the KKAY mouse…”
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Insulin as a Surface Marker on Isolated Cells from Rat Pancreatic Islets by Kaplan, David R., Colca, Jerry R., McDaniel, Michael L.

“…Immunoreactive insulin was shown to exist as a surface molecule in the plasma membrane of dispersed rat pancreatic islet cells. The intact cells were stained…”
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Ciglitazone, a hypoglycemic agent: early effects on the pancreatic islets of ob/ob mice by Colca, J R, Wyse, B M, Sawada, G, Jodelis, K S, Connell, C L, Fletcher-McGruder, B L, Palazuk, B J, Diani, A R

“…Chronic administration of ciglitazone (5-4[1-methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4 dione) decreased both plasma glucose and insulin concentrations…”
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Persistence of immunoreactive insulin, glucagon and pancreatic polypeptide in the plasma of depancreatized chickens by Colca, J R, Hazelwood, R L

“…The present study evaluates the possibility that an extra-pancreatic source of insulin exists in chickens. The effect of pancreatectomy on plasma levels of…”
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Active calcium uptake by islet-cell endoplasmic reticulum by Colca, J R, McDonald, J M, Kotagal, N, Patke, C, Fink, C J, Greider, M H, Lacy, P E, McDaniel, M L

“…Active calcium uptake was demonstrated in a subcellular fraction of islets which was enriched in endoplasmic reticulum. Calcium uptake was stimulated by ATP in…”
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