Search Results - "Colby, Jennifer K"

The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor by Liu, Yi, Colby, Jennifer K, Zuo, Xiangsheng, Jaoude, Jonathan, Wei, Daoyan, Shureiqi, Imad

“…Peroxisome proliferator-activated receptor-delta (PPAR-δ), one of three members of the PPAR group in the nuclear receptor superfamily, is a ligand-activated…”
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Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4 by Fang, Xiaohui, Abbott, Jason, Cheng, Linda, Colby, Jennifer K, Lee, Jae Woo, Levy, Bruce D, Matthay, Michael A

“…Previous studies demonstrated that bone marrow-derived mesenchymal stem (stromal) cells (MSCs) reduce the severity of acute lung injury in animal models and in…”
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Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ by Liu, Yi, Deguchi, Yasunori, Wei, Daoyan, Liu, Fuyao, Moussalli, Micheline J., Deguchi, Eriko, Li, Donghui, Wang, Huamin, Valentin, Lovie Ann, Colby, Jennifer K., Wang, Jing, Zheng, Xiaofeng, Ying, Haoqiang, Gagea, Mihai, Ji, Baoan, Shi, Jiaqi, Yao, James C., Zuo, Xiangsheng, Shureiqi, Imad

“…Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with…”
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Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective by Abdulnour, Raja-Elie E., Dalli, Jesmond, Colby, Jennifer K., Krishnamoorthy, Nandini, Timmons, Jack Y., Tan, Sook Hwa, Colas, Romain A., Petasis, Nicos A., Serhan, Charles N., Levy, Bruce D.

“…Unregulated acute inflammation can lead to collateral tissue injury in vital organs, such as the lung during the acute respiratory distress syndrome. In…”
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P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis by Fuchs-Young, Robin, Shirley, Stephanie H., Lambertz, Isabel, Colby, Jennifer K. L., Tian, Jie, Johnston, Dennis, Gimenez-Conti, Irma B., Donehower, Lawrence A., Conti, Claudio J., Hursting, Stephen D.

“…Clinical studies show that estrogen receptor-α (ER) expressing tumors tend to have better prognosis, respond to antiestrogen therapy and have wild-type p53…”
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Paracrine Overexpression of Insulin-Like Growth Factor-1 Enhances Mammary Tumorigenesis in Vivo by de Ostrovich, Krisztina Kovács, Lambertz, Isabel, Colby, Jennifer K.L, Tian, Jie, Rundhaug, Joyce E, Johnston, Dennis, Conti, Claudio J, DiGiovanni, John, Fuchs-Young, Robin

“…Insulin-like growth factor-1 (IGF-1) stimulates proliferation, regulates tissue development, protects against apoptosis, and promotes the malignant phenotype…”
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Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia by Lashinger, Laura M, Malone, Lauren M, McArthur, Mark J, Goldberg, Jason A, Daniels, Elizabeth A, Pavone, Amy, Colby, Jennifer K, Smith, Nicole C, Perkins, Susan N, Fischer, Susan M, Hursting, Stephen D

“…Risk of pancreatic cancer, the fourth deadliest cancer in the United States, is increased by obesity. Calorie restriction (CR) prevents obesity, suppresses…”
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Oxygenated lipid signaling in tumor-associated macrophages—focus on colon cancer by Colby, Jennifer K., Jaoude, Jonathan, Liu, Fuyao, Shureiqi, Imad

“…Polyunsaturated fatty acids (PUFAs) are enzymatically converted to a variety of bioactive products through insertion of molecular oxygen. PUFA-derived…”
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Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia by Colby, Jennifer K, Abdulnour, Raja-Elie E, Sham, Ho Pan, Dalli, Jesmond, Colas, Romain A, Winkler, Jeremy W, Hellmann, Jason, Wong, Blenda, Cui, Ye, El-Chemaly, Souheil, Petasis, Nicos A, Spite, Matthew, Serhan, Charles N, Levy, Bruce D

“…Acute lung injury is a life-threatening condition caused by disruption of the alveolar-capillary barrier leading to edema, influx of inflammatory leukocytes,…”
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The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue by Wang, Xingya, Colby, Jennifer K.L., Yang, Peiying, Fischer, Susan M., Newman, Robert A., Klein, Russell D.

“…Over-expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 has been demonstrated to play a significant role in the tumorigenesis of colon, lung, breast,…”
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Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells by Awji, Elias G, Chand, Hitendra, Bruse, Shannon, Smith, Kevin R, Colby, Jennifer K, Mebratu, Yohannes, Levy, Bruce D, Tesfaigzi, Yohannes

“…Our previous studies showed that cigarette smokers who are exposed to wood smoke (WS) are at an increased risk for chronic bronchitis and reduced lung…”
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A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation by Tavares, Alexander H, Colby, Jennifer K, Levy, Bruce D, Abdulnour, Raja-Elie Edward

“…Selective intra-bronchial instillation of hydrochloric acid (HCl) to the murine left mainstem bronchus causes acute tissue injury with histopathologic findings…”
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Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection by Colby, Jennifer K, Gott, Katherine M, Wilder, Julie A, Levy, Bruce D

“…Lipoxins (LX) are proresolving mediators that augment host defense against bacterial infection. Here, we investigated roles for LX in lung clearance of the…”
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15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia by Sham, Ho Pan, Walker, Katherine H., Abdulnour, Raja-Elie E., Krishnamoorthy, Nandini, Douda, David N., Norris, Paul C., Barkas, Ioanna, Benito-Figueroa, Sarah, Colby, Jennifer K., Serhan, Charles N., Levy, Bruce D.

“…Specialized proresolving mediators (SPMs) decrease NF-κB activity to prevent excessive tissue damage and promote the resolution of acute inflammation…”
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Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immune- and cell proliferation-related genes by Wang, Xingya, Colby, Jennifer K.L., Rengel, Robert C., Fischer, Susan M., Clinton, Steven K., Klein, Russell D.

“…The mechanisms whereby cyclooxygenase‐2 (COX‐2) overexpression may contribute to bladder carcinogenesis remain unknown. We recently developed a transgenic…”
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Abstract 2224: Increased 15-lipoxygenase-1 activity limits tumor development in the azoxymethane mouse model of colon cancer: impact of omega-3-acid ethyl esters by Zuo, Xiangsheng, Colby, Jennifer K., Liu, Fuyao, Gao, Shen, Wu, Ling, Jaoude, Jonathan C., Moussalli, Micheline J., Tan, Lin, Yang, Peiying, Shureiqi, Imad

“…Pro-inflammatory signaling has been shown to promote colorectal tumorigenesis and is a target for the development of effective chemopreventive approaches. The…”
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Aspirin Triggered Lipoxin A4 regulates NF-κB and induces antimicrobial peptides expression in airway epithelial cells to limit mucosal inflammation to enhance host response in pneumonia by Sham, Ho Pan, Abdulnour, Raja-Elie E, Krishnamoorthy, Nandini, Douda, David N, Colby, Jennifer K, Levy, Bruce D

“…Bacteria induced pneumonia remains a major global threat to health. Even with effective antibiotic treatment, the host response can be exuberant, resulting in…”
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Abstract 3821: Rapid acceleration of KRAS- mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARD by Liu, Yi, Deguchi, Yasunori, Wei, Daoyan, Moussalli, Micheline J., Liu, Fuyao, Deguchi, Eriko, Li, Donghui, Wang, Huamin, Valentin, Lovie Ann, Colby, Jennifer K., Wang, Jing, Zheng, Xiaofeng, Ying, Haoqiang, Gagea, Mihai, Ji, Baoan, Shi, Jiaqi, Yao, James C., Zuo, Xiangsheng, Shureiqi, Imad

“…Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with…”
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Progressive Metaplastic and Dysplastic Changes in Mouse Pancreas Induced by Cyclooxygenase-2 Overexpression by Colby, Jennifer K.L., Klein, Russell D., McArthur, Mark J., Conti, Claudio J., Kiguchi, Kaoru, Kawamoto, Toru, Riggs, Penny K., Pavone, Amy I., Sawicki, Janet, Fischer, Susan M.

“…Cyclooxygenase-2 (COX-2) overexpression is an established factor linking chronic inflammation with metaplastic and neoplastic change in various tissues. We…”
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15-epi-Lipoxin A 4 , Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia by Sham, Ho Pan, Walker, Katherine H, Abdulnour, Raja-Elie E, Krishnamoorthy, Nandini, Douda, David N, Norris, Paul C, Barkas, Ioanna, Benito-Figueroa, Sarah, Colby, Jennifer K, Serhan, Charles N, Levy, Bruce D

“…Specialized proresolving mediators (SPMs) decrease NF-κB activity to prevent excessive tissue damage and promote the resolution of acute inflammation…”
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