Search Results - "Colburn, Nancy H"

Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro by Li, Weidong, Saud, Shakir M., Young, Matthew R., Colburn, Nancy H., Hua, Baojin

“…Cryptotanshinone (CPT) is a natural compound extracted from herbal medicine that has been previously shown to possess antitumor properties in various types of…”
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Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice by Li, Weidong, Hua, Baojin, Saud, Shakir M., Lin, Hongsheng, Hou, Wei, Matter, Matthias S., Jia, Libin, Colburn, Nancy H., Young, Matthew R.

“…Colorectal cancer, a leading cause of cancer death, has been linked to inflammation and obesity. Berberine, an isoquinoline alkaloid, possesses…”
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Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe by Mitsunaga, Makoto, Kosaka, Nobuyuki, Choyke, Peter L, Young, Matthew R, Dextras, Christopher R, Saud, Shakir M, Colburn, Nancy H, Sakabe, Masayo, Nagano, Tetsuo, Asanuma, Daisuke, Urano, Yasuteru, Kobayashi, Hisataka

“…Screening colonoscopy to monitor for early colitis-associated colon cancer (CAC) is difficult due to the aberrant mucosal patterns associated with…”
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Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling by Wei, Qiou, Jiang, Hong, Xiao, Zhen, Baker, Alyson, Young, Matthew R, Veenstra, Timothy D, Colburn, Nancy H

“…Oxidative stress is known to cause tumorigenesis through induction of DNA and lipid damage. It also promotes cancer progression through a largely unknown…”
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Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis by JANSEN, Aaron P, CAMALIER, Corinne E, COLBURN, Nancy H

“…Programmed cell death 4 (Pdcd4) is a novel repressor of in vitro transformation. Pdcd4 directly inhibits the helicase activity of eukaryotic translation…”
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An integrated understanding of the physiological response to elevated extracellular phosphate by Camalier, Corinne E., Yi, Ming, Yu, Li-Rong, Hood, Brian L., Conrads, Kelly A., Lee, Young Jae, Lin, Yiming, Garneys, Laura M., Bouloux, Gary F., Young, Matthew R., Veenstra, Timothy D., Stephens, Robert M., Colburn, Nancy H., Conrads, Thomas P., Beck Jr, George R.

“…Recent studies have suggested that changes in serum phosphate levels influence pathological states associated with aging such as cancer, bone metabolism, and…”
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Translation Inhibitor Pdcd4 Is Targeted for Degradation during Tumor Promotion by SCHMID, Tobias, JANSEN, Aaron P, BAKER, Alyson R, HEGAMYER, Glenn, HAGAN, John P, COLBURN, Nancy H

“…Inactivation of tumor suppressors is among the rate-limiting steps in carcinogenesis that occur during the tumor promotion stage. The translation inhibitor…”
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Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies by Wei, Qiou, Jiang, Hong, Matthews, Connie P, Colburn, Nancy H

“…Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study…”
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Bioactive food components, inflammatory targets, and cancer prevention by Kim, Young S, Young, Matthew R, Bobe, Gerd, Colburn, Nancy H, Milner, John A

“…Various dietary components may modify chronic inflammatory processes at the stage of cytokine production, amplification of nuclear factor-kappaB-mediated…”
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The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation by Yang, Hsin-Sheng, Jansen, Aaron P., Komar, Anton A., Zheng, Xiaojing, Merrick, William C., Costes, Sylvain, Lockett, Stephen J., Sonenberg, Nahum, Colburn, Nancy H.

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P53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase by YUNFENG ZHAO, CHAISWING, Luksana, VELEZ, Joyce M, BATINIC-HABERLE, Ines, COLBUM, Nancy H, OBERLEY, Terry D, CLAIR, Daret K. St

“…The tumor suppressor gene p53 is activated by reactive oxygen species-generating agents. After activation, p53 migrates to mitochondria and nucleus, a response…”
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Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression To Suppress Colon Carcinoma Cell Invasion by Yang, Hsin-Sheng, Matthews, Connie P., Clair, Timothy, Wang, Qing, Baker, Alyson R., Li, Chou-Chi H., Tan, Tse-Hua, Colburn, Nancy H.

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Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 by Blees, Johanna S, Bokesch, Heidi R, Rübsamen, Daniela, Schulz, Kathrin, Milke, Larissa, Bajer, Magdalena M, Gustafson, Kirk R, Henrich, Curtis J, McMahon, James B, Colburn, Nancy H, Schmid, Tobias, Brüne, Bernhard

“…Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized…”
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A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 Is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A by Yang, Hsin-Sheng, Cho, Myung-Haing, Zakowicz, Halina, Hegamyer, Glenn, Sonenberg, Nahum, Colburn, Nancy H.

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Impact of dietary components on NK and Treg cell function for cancer prevention by Kim, Young S., Sayers, Thomas J., Colburn, Nancy H., Milner, John A., Young, Howard A.

“…An important characteristic of cancer is that the disease can overcome the surveillance of the immune system. A possible explanation for this resistance arises…”
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Nucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal region by Song, Changcheng, Wang, Qing, Song, Changzheng, Lockett, Stephen J., Colburn, Nancy H., Li, Chou-Chi H., Wang, Ji Ming, Rogers, Thomas J.

“…Valosin-containing protein (VCP or p97), a member of the AAA family (ATPases associated with diverse cellular activities), plays a key role in many important…”
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Histone Deacetylase Inhibition Down-Regulates Cyclin D1 Transcription by Inhibiting Nuclear Factor-κB/p65 DNA Binding by Hu, Jing, Colburn, Nancy H.

“…Histone deacetylase (HDAC) inhibitors are emerging as a promising new class of cancer therapeutic agents. HDAC inhibitors relieve the deacetylation of histone…”
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Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4 by Schmid, Tobias, Blees, Johanna S, Bajer, Magdalena M, Wild, Janine, Pescatori, Luca, Cuzzucoli Crucitti, Giuliana, Scipione, Luigi, Costi, Roberta, Henrich, Curtis J, Brüne, Bernhard, Colburn, Nancy H, Di Santo, Roberto

“…The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased…”
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Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial by Bobe, Gerd, Albert, Paul S, Sansbury, Leah B, Lanza, Elaine, Schatzkin, Arthur, Colburn, Nancy H, Cross, Amanda J

“…Serum interleukin-6 (IL-6), a proinflammatory cytokine, is considered an indicator of inflammation and may be an indicator of colorectal carcinogenesis given…”
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Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis by Camalier, Corinne E, Young, Matthew R, Bobe, Gerd, Perella, Christine M, Colburn, Nancy H, Beck, Jr, George R

“…Recent results suggest a paradigm shift from viewing inorganic phosphate as a passive requirement for basic cell functions to an active regulator of cell…”
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