Search Results - "Colbert, Melissa C"

Neural Crest Cells Retain Multipotential Characteristics in the Developing Valves and Label the Cardiac Conduction System by Nakamura, Tomoki, Colbert, Melissa C, Robbins, Jeffrey

“…Multipotent neural crest cells (NCCs) are a major extracardiac component of cardiovascular development. Although recognized as contributing cells to the…”
Get full text

Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors by Patel, Ami V, Johansson, Gunnar, Colbert, Melissa C, Dasgupta, Biplab, Ratner, Nancy

“…Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas with minimal therapeutic opportunities. We observed that lipid droplets (LDs)…”
Get full text

Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development by Nakamura, Tomoki, Gulick, James, Colbert, Melissa C, Robbins, Jeffrey

“…Mutations within the protein tyrosine phosphatase, SHP2, which is encoded by PTPN11, cause a significant proportion of Noonan syndrome (NS) cases, typically…”
Get full text

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome by Krenz, Maike, Gulick, James, Osinska, Hanna E, Colbert, Melissa C, Molkentin, Jeffery D, Robbins, Jeffrey

“…Noonan syndrome (NS) is the most common nonchromosomal genetic disorder associated with cardiovascular malformations. The most prominent cardiac defects in NS…”
Get full text

Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy by Dorn, Gerald W, Yussman, Martin G, Toyokawa, Tsuyoshi, Odley, Amy, Lynch, Roy A, Wu, Guangyu, Colbert, Melissa C, Aronow, Bruce J, Lorenz, John N

“…Loss of cardiomyocytes through programmed cell death is a key event in the development of heart failure, but the inciting molecular mechanisms are largely…”
Get full text

Nestin-CreER Mice Reveal DNA Synthesis by Nonapoptotic Neurons following Cerebral Ischemia–Hypoxia by Burns, Kevin A., Ayoub, Albert E., Breunig, Joshua J., Adhami, Faisal, Weng, Wei-Lan, Colbert, Melissa C., Rakic, Pasko, Kuan, Chia-Yi

“…The standard method of detecting neurogenesis uses bromodeoxyuridine (BrdU) to label DNA synthesis followed by double labeling with neuronal markers. However,…”
Get full text

Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes by Allen, 2nd, Zegary J, Waclaw, Ronald R, Colbert, Melissa C, Campbell, Kenneth

“…Interneurons in the glomerular layer (GL) of the olfactory bulb represent a diverse set of cells, which can be identified by distinct expression of different…”
Get full text

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition by Sussman, Mark A., Lim, Hae W., Gude, Natalie, Taigen, Tyler, Olson, Eric N., Robbins, Jeffrey, Colbert, Melissa C., Gualberto, Antonio, Wieczorek, David F., Molkentin, Jeffery D.

“…Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a…”
Get full text

Prothrombin Deficiency Results in Embryonic and Neonatal Lethality in Mice by Sun, William Y., Witte, David P., Degen, Jay L., Colbert, Melissa C., Burkart, Melissa C., Holmback, Kenn, Xiao, Qing, Bugge, Thomas H., Sandra J. F. Degen

“…The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet…”
Get full text

Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells by Wang, Linping, Mear, John P., Kuan, Chia‐Yi, Colbert, Melissa C.

“…Retinoic acid (RA), the active metabolite of vitamin A, regulates cellular growth and differentiation during embryonic development. In excess, this vitamin is…”
Get full text

Remodeling of Gap Junctions in Mouse Hearts Hypertrophied by Forced Retinoic Acid Signaling by van Veen, Toon A.B., van Rijen, Harold V.M., Wiegerinck, Rob F., Opthof, Tobias, Colbert, Melissa C., Clement, Sophie, de Bakker, Jacques M.T., Jongsma, Habo J.

“…T. A. B. van Veen, H. V. M. van Rijen, R. F. Wiegerinck, T. Opthof, M. C. Colbert, S. Clement, J. M. T. de Bakker and H. J. Jongsma. Remodeling of Gap…”
Get full text

Retinoic Acid Inhibits Cardiac Neural Crest Migration by Blocking c-Jun N-Terminal Kinase Activation by Li, Jian, Molkentin, Jeffery D, Colbert, Melissa C

“…Retinoic acid (RA), a potent teratogen, produces a characteristic set of embryonic cardiovascular malformations similar to those observed in neural crest…”
Get full text

Retinoids and cardiovascular developmental defects by Colbert, Melissa C

“…Vitamin A and related retinoids are critical regulators of normal cardiovascular development. Extreme variations in retinoid levels, too little or too much,…”
Get full text

Midgestational Lethality in Mice Lacking the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Is Associated with Abrupt Cardiomyocyte Death by Qian, Jin, Colbert, Melissa C, Witte, David, Kuan, Chia-Yi, Gruenstein, Eric, Osinska, Hanna, Lanske, Beate, Kronenberg, Henry M, Clemens, Thomas L

“…PTHrP is a key developmental regulatory protein and a potent vasoactive agent. Previous studies have shown that mice lacking either the Pthrp or the PTH type 1…”
Get full text

Large-scale reprogramming of cranial neural crest gene expression by retinoic acid exposure by Williams, Sarah S, Mear, John P, Liang, Hung-Chi, Potter, S. Steven, Aronow, Bruce J, Colbert, Melissa C

“…1 Divisions of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229 2 Molecular Cardiovascular Biology, Cincinnati…”
Get full text

The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse by Muraoka, R S, Sun, W Y, Colbert, M C, Waltz, S E, Witte, D P, Degen, J L, Friezner Degen, S J

“…The Ron/STK receptor tyrosine kinase is a member of the c-Met family of receptors and is activated by hepatocyte growth factor-like protein (HGFL). Ron…”
Get full text

Reduced Blood Pressure and Increased Sensitivity of the Vasculature to Parathyroid Hormone-Related Protein (PTHrP) in Transgenic Mice Overexpressing the PTH/PTHrP Receptor in Vascular Smooth Muscle by Qian, Jin, Lorenz, John N., Maeda, Shigeto, Sutliff, Roy L., Weber, Craig, Nakayama, Toshiyuki, Colbert, Melissa C., Paul, Richard J., Fagin, James A., Clemens, Thomas L.

“…Abstract PTH-related protein (PTHrP) is produced in vascular smooth muscle, where it is postulated to exert vasorelaxant properties by activation of the…”
Get full text

Endogenous Retinoic Acid Signaling Colocalizes With Advanced Expression of the Adult Smooth Muscle Myosin Heavy Chain Isoform During Development of the Ductus Arteriosus by Colbert, Melissa C, Kirby, Margaret L, Robbins, Jeffrey

“…During fetal development, a specialized vessel, the ductus arteriosus, shunts blood from the pulmonary artery to the aorta, thus bypassing the lungs. The…”
Get full text

Local Sources of Retinoic Acid Coincide with Retinoid-Mediated Transgene Activity During Embryonic Development by Colbert, Melissa C., Linney, Elwood, LaMantia, Anthony-Samuel

“…We have assessed whether retinoic acid (RA) comes from local sources or is available widely to activate gene expression in embryos. We used an RA-responsive…”
Get full text

Editorial: Prenatal Lethality in PTH Type I Receptor Null Mice—Interrogating the Usual Suspects by Clemens, Thomas L, Qian, Jin, Colbert, Melissa C

Get full text