Search Results - "Colagiovanni, Dorothy B"

Oral CBD-rich hemp extract modulates sterile inflammation in female and male rats by Hopkins, Shelby, Kelley, Tel, Roller, Rachel, Thompson, Robert S, Colagiovanni, Dorothy B, Chupka, Kris, Fleshner, Monika

“…Cannabidiol (CBD) extract from the cannabis plant has biomedical and nutraceutical potential. Unlike tetrahydrocannabinol (THC), CBD products produce few…”
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S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury by Cox, Andrew G., Saunders, Diane C., Kelsey, Peter B., Conway, Allie A., Tesmenitsky, Yevgenia, Marchini, Julio F., Brown, Kristin K., Stamler, Jonathan S., Colagiovanni, Dorothy B., Rosenthal, Gary J., Croce, Kevin J., North, Trista E., Goessling, Wolfram

“…Toxic liver injury is a leading cause of liver failure and death because of the organ’s inability to regenerate amidst massive cell death, and few therapeutic…”
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Juvenile toxicity study of faropenem medoxomil in beagle puppies by Faqi, Ali S., Lanphear, Chery, Gill, Stan, Colagiovanni, Dorothy B.

“…▶ Body weight in males and kidney findings at 1400 mg/kg/day were considered adverse. ▶ An apparent increase in the rate of clearance characterized by a…”
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Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] in mice by Desjardins, John, Emerson, David L, Colagiovanni, Dorothy B, Abbott, Elizabeth, Brown, Eric N, Drolet, Daniel W

“…OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] is a liposomal formulation of the…”
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A nonclinical safety and pharmacokinetic evaluation of N6022: A first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma by Colagiovanni, Dorothy B., Drolet, Daniel W., Langlois-Forget, Emilie, Piché, Marie-Pier, Looker, Doug, Rosenthal, Gary J.

“…► Two weeks of daily N6022 via IV administration was well tolerated. ► High doses of N6022 caused possible liver toxicity related to redox status. ► Inhibiting…”
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Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities by Sun, Xicheng, Qiu, Jian, Strong, Sarah A., Green, Louis S., Wasley, Jan W.F., Blonder, Joan P., Colagiovanni, Dorothy B., Mutka, Sarah C., Stout, Adam M., Richards, Jane P., Rosenthal, Gary J.

“…The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious S-nitrosoglutathione reductase (GSNOR) inhibitor and is…”
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Discovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases by Sun, Xicheng, Wasley, Jan W. F, Qiu, Jian, Blonder, Joan P, Stout, Adam M, Green, Louis S, Strong, Sarah A, Colagiovanni, Dorothy B, Richards, Jane P, Mutka, Sarah C, Chun, Lawrence, Rosenthal, Gary J

“…S-Nitrosoglutathione reductase (GSNOR) regulates S-nitrosothiols (SNOs) and nitric oxide (NO) in vivo through catabolism of S-nitrosoglutathione (GSNO). GSNOR…”
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Structure–activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification by Sun, Xicheng, Qiu, Jian, Strong, Sarah A., Green, Louis S., Wasley, Jan W.F., Blonder, Joan P., Colagiovanni, Dorothy B., Stout, Adam M., Mutka, Sarah C., Richards, Jane P., Rosenthal, Gary J.

“…The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs)…”
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Structure–activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: Pyrrole regioisomers and propionic acid replacement by Sun, Xicheng, Qiu, Jian, Strong, Sarah A., Green, Louis S., Wasley, Jan W.F., Colagiovanni, Dorothy B., Mutka, Sarah C., Blonder, Joan P., Stout, Adam M., Richards, Jane P., Chun, Lawrence, Rosenthal, Gary J.

“…S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through…”
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Preclinical 28-Day Inhalation Toxicity Assessment of S-Nitrosoglutathione in Beagle Dogs and Wistar Rats by Colagiovanni, Dorothy B., Borkhataria, Daxa, Looker, Doug, Schuler, Detlef, Bachmann, Corinna, Sagelsdorff, Peter, Honarvar, Naveed, Rosenthal, Gary J.

“…To support clinical development of S-nitrosoglutathione (GSNO) as a therapeutic agent, 28-day toxicology studies in rats and dogs were conducted. Rats…”
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An intranasal irritation assessment of antibacterial ointment alone or in combination with mupirocin versus Bactroban Nasal ® in rabbits by Faqi, Ali S., Bell, Stacie J., Gill, Stan, Colagiovanni, Dorothy B.

“…The purpose of this study was to evaluate the potential irritating effects and the systemic exposure level of an antibacterial ointment containing REP8839 as a…”
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High gamma-glutamyltransferase (GGT) activity in human breast milk confounds interpretation of high serum GGT activity in a nursing infant with liver disease by Colagiovanni, Dorothy B, Meyer, Dennis J, Wolf, Julie M, Hart, Karen, Abbott, Elizabeth, Santos, Corrie

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Safety Assessment of 4′-Thio-β-d-Arabinofuranosylcytosine in the Beagle Dog Suggests a Drug-Induced Centrally Mediated Effect on the Hypothalamic-Pituitary-Adrenal Axis by Colagiovanni, Dorothy B., Drolet, Daniel W., Dihel, Larry, Meyer, Dennis J., Hart, Karen, Wolf, Julie

“…4′-Thio-β-d-arabinofuranosylcytosine (OSI-7836) is a nucleoside analogue with structural similarity to gemcitabine and cytarabine (ara-C). Myelosuppression,…”
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Chemical Suppression of a Subpopulation of Primitive Hematopoietic Progenitor Cells: 1,3-Butadiene Produces a Hematopoietic Defect Similar to Steel or White Spotted Mutations in Mice by Colagiovanni, Dorothy B., Stillman, Wayne S., Irons, Richard D.

“…Chronic exposure of mice to 1,3-butadiene produces a macrocytic-megaloblastic anemia, thymic hypoplasia, and an increased incidence of T-cell…”
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Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis by Ksontini, R, Colagiovanni, D B, Josephs, M D, Edwards, 3rd, C K, Tannahill, C L, Solorzano, C C, Norman, J, Denham, W, Clare-Salzler, M, MacKay, S L, Moldawer, L L

“…Apoptosis is a physiologic process that serves to eliminate cells during development or in response to immunologic regulation. In acute inflammation, however,…”
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High [gamma]-Glutamyltransferase (GGT) Activity in Human Breast Milk Confounds Interpretation of High Serum GGT Activity in a Nursing Infant with Liver Disease by Colagiovanni, Dorothy B, Meyer, Dennis J, Wolf, Julie M, Hart, Karen

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S-nitrosothiol signaling regulates hepatogenesis and improves outcome following toxic liver injury by Cox, Andrew G., Saunders, Diane C., Kelsey, Peter, Conway, Allie A., Tesmenitsky, Yevgenia, Marchini, Julio F., Brown, Kristin K., Stamler, Jonathan S., Colagiovanni, Dorothy B., Rosenthal, Gary J., Croce, Kevin J., North, Trista E., Goessling, Wolfram

“…Toxic liver injury is a leading cause of liver failure and death, due to the organ’s inability to regenerate amidst massive cell death, and few therapeutic…”
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Synergistic Action of the Benzene Metabolite Hydroquinone on Myelopoietic Stimulating Activity of Granulocyte/Macrophage Colony-Stimulating Factor in vitro by Irons, Richard D., Stillman, Wayne S., Colagiovanni, Dorothy B., Henry, Veronica A.

“…The effects of in vitro pretreatment with benzene metabolites on colony-forming response of murine bone marrow cells stimulated with recombinant…”
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Murine thymic lymphoma is associated with a species-specific hematopoietic progenitor cell subpopulation by Irons, Richard D., Colagiovanni, Dorothy B., Stillman, Wayne S.

“…Many strains of laboratory mouse are uniquely susceptible to the development of T cell lymphoma/leukemia, either spontaneously or as a result of chemical or…”
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EVALUATING THE EFFICACY OF AMIKACIN IN LOW-CLEARANCE UNILAMELLAR LIPOSOMES IN A S. AUREUS LOCAL INFECTION MODEL by Garrison, Augusta E., Bendele, Ray, Knauer, Susan, Wolf, Julie, Moon-McDermott, Lotus, Gill, Stan, Colagiovanni, Dorothy B.

“…Traditional therapies for Staphylococcal infections such as osteomyelitis or localized abscesses have a difficult time penetrating into tissue sites. To…”
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